Mind your P's and Q's: the coming of age of semiconducting polymer dots and semiconductor quantum dots in biological applications

Massey, Melissa; Wu, Miao; Conroy, Erin M.; Algar, W. Russ

doi:10.1016/j.copbio.2014.11.006

Cited by 111 publications

(82 citation statements)

References 90 publications

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“…Risks are mitigated by the minute amounts required for diagnostic assays and by using newly developed QDs that do not contain heavy metals. These QDs are composed of small organic molecules and polymers (p‐dots) and so show lower toxicity than their heavy metal counterparts, yet retain their extraordinary optical properties . Given these advances, it is evident that combining the advantageous optical properties of nanomaterials with programmable molecular biology approaches such as isothermal amplification could enable the design of a new class of sensitive, robust and versatile diagnostic tests.…”

Section: Emerging Technologiesmentioning

confidence: 99%

Genome‐wide host RNA signatures of infectious diseases: discovery and clinical translation

et al. 2017

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SummaryThe use of whole blood gene expression to derive diagnostic biomarkers capable of distinguishing between phenotypically similar diseases holds great promise but remains a challenge. Differential gene expression analysis is used to identify the key genes that undergo changes in expression relative to healthy individuals, as well as to patients with other diseases. These key genes can act as diagnostic, prognostic and predictive markers of disease. Gene expression ‘signatures’ in the blood hold the potential to be used for the diagnosis of infectious diseases, where current diagnostics are unreliable, ineffective or of limited potential. For diagnostic tests based on RNA signatures to be useful clinically, the first step is to identify the minimum set of gene transcripts that accurately identify the disease in question. The second requirement is rapid and cost‐effective detection of the gene expression levels. Signatures have been described for a number of infectious diseases, but ‘clinic‐ready’ technologies for RNA detection from clinical samples are limited, though existing methods such as RT‐PCR are likely to be superseded by a number of emerging technologies, which may form the basis of the translation of gene expression signatures into routine diagnostic tests for a range of disease states.

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Section: Emerging Technologiesmentioning

confidence: 99%

Genome‐wide host RNA signatures of infectious diseases: discovery and clinical translation

et al. 2017

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“…For example, Pdots and CPNs have been discussed and compared to other nanoprobes, such as dye-loaded nanobeads, 13,17,18 semiconductor quantum dots (Qdots), 13,16 and carbon dots. 13,18 We recently performed a systematic comparative study on the cytotoxicity of Pdots and Qdots, both at the gross cell level (e.g., cell viability, proliferation, and necrosis) and at a molecular level (e.g., redox stress).…”

mentioning

confidence: 99%

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

et al. 2016

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“…Some fluorescent-labeled particles [43] in tissue homogenates were analyzed by plate reader. In some other materials [44], like quantum dots with heavy metal cores, it was more appropriate to apply multiplexing and multicolor imaging through single-particle Förster resonance energy transfer assays [45]. However, qualitative analysis with light microscope (LM) and electron microscope (EM) failed to show sufficient and significant evidence in current studies.…”

Section: Biodistributionmentioning

confidence: 60%

Toxicity assessment of nanoparticles in various systems and organs

Yang

Qin

Zeng

et al. 2017

Nanotechnology Reviews

183

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Abstract:In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. While in vitro studies have been increasing constantly, in vivo studies of nanoparticles have not established a unified system until now. Predictive models and validated standard methods are imperative. This review summarizes the current progress in approaches assessing nanotoxicity in main systems, including the hepatic and renal, gastrointestinal, pulmonary, cardiovascular, nervous, and immune systems. Histopathological studies and specific functional examinations in each system are elucidated. Related injury mechanisms are also discussed.

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Mind your P's and Q's: the coming of age of semiconducting polymer dots and semiconductor quantum dots in biological applications

Cited by 111 publications

References 90 publications

Genome‐wide host RNA signatures of infectious diseases: discovery and clinical translation

Genome‐wide host RNA signatures of infectious diseases: discovery and clinical translation

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

Toxicity assessment of nanoparticles in various systems and organs

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