Self-care results in individual physical and mental health benefits, however, if understood and carried out from an ethical perspective that incorporates community values. We set out to characterize the academic and non-scientific communities conceptions of self-care through an integrative review, which the hypothesis that the COVID-19 pandemic engendered a more global community-based conception of self-care. The research of 800 scientific articles and 1045 popular media evidenced dissonance between the scientific community’s approach to self-care, which has a relatively more clinical focus and an individual and physical nature, and the popular notions of physical and mental self-care that focus on self-awareness and well-being. The pandemic has influenced the application of self-care with the intensification of clinical analyses and reports and containment measures in international studies. The dialogical, deliberative, and regulatory nature of bioethics underlies the importance of the educational process in shaping citizens who understand self-care as a biological and ethical principle. We conclude that the pandemic opens a new chapter in the history as it impels individuals to look at themselves and others mutually, thus revealing self-care as an ethical principle, which demands a decision-making from a critical, autonomous, and proactive awareness that aims to promote global health.