Mineral Elements Content of Selected Kenyan Antidiabetic Medicinal Plants

Wm, Arika; Pe, Ogola

doi:10.4172/2379-1764.1000160

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…These bioactive principles could be specific mineral elements or phytochemicals that modulate various metabolic pathways at the cellular and molecular levels, thereby preventing, controlling, or reversing diabetes in affected patients. The present study's findings revealed the presence of antidiabetic-associated mineral elements in the aqueous leaf extracts of the studied plants, which may have played significant roles in averting alloxan-induced hyperglycaemia in mice [62]. Research has indicated that Zn modulates the metabolism of proteins, carbohydrates, and lipids by targeting affecting various molecules and pathways [63].…”

Section: Discussionmentioning

confidence: 56%

In Vivo Antidiabetic Efficacy, Mineral Element Composition, and Qualitative Phytochemistry of the Aqueous Leaf Extracts of Pentas zanzibarica (Klotzsch.) Vatke and Olea europaea subspecies africana (Mill.)

Moriasi

Kibiti

Ngugi

2021

Preprint

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Persistent hyperglycaemia is the hallmark of diabetes and is accountable for the devastating complications, which cause high morbidity and mortality. Conventional anti-diabetic agents are only palliative and characterised with limited efficacy, adverse effects, high costs, inaccessibility, prompting the need for better alternatives. Therefore, we investigated the in vivo hypoglycaemic activities, elemental composition, and qualitative phytochemistry of the aqueous leaf extracts of P. zanzibarica and O. europaea subspecies africana as potential sources of affordable, safer, accessible, and potent anti-diabetic therapies. In vivo hypoglycaemic activities of the studied plant extracts were evaluated at three dose levels of 50, 100, and 150 mg/Kg body weight (bw) in Alloxan-induced hyperglycaemic Swiss albino mice. The elemental composition of the plant extracts was analysed using the energy dispersive x-ray fluorescence spectroscopy (EDXRF System) and the atomic absorption spectrometry (AAS). Qualitative phytochemical screening was done following standard procedures. In this study, the aqueous leaf extract of P. zanzibarica, significantly (p<0.05) reduced alloxan-induced hyperglycaemia in mice from 163.26±2.24 mg/dL (at 0h) to 52.12±1.16 mg/dL (at the 4th h) at a dose of 50 mg/Kg body weight, 166.98±1.56 mg/dL (at 0h) to 48.90±1.40 mg/dL (at 4th h) at a dose of 100 mg/Kg body weight, and 168.64±2.96 mg/dL (at 0h) to 42.46±1.80 mg/dL (at 4th h) at a dose of 150 mg/Kg body weight, respectively. Similarly, the aqueous leaf extract of O. europaea subspecies africana significantly (p<0.05) reduced hyperglycaemia from 165.74±3.66 mg/dL (at 0h) to 65.26±1.46 mg/dL (at the 4th h) at a dose of 50 mg/Kg body weight, 158.14±3.49 mg/dL (at 0h) to 53.68±1.48 mg/dL (at the 4th h) at a dose of 100 mg/Kg body weight, and from 161.66±2.19 mg/dL (at 0h) to 44.48±1.35 mg/dL (at the 4th h) at a dose of 150 mg/Kg body weight, respectively Furthermore, the extracts contained chromium (Cr), zinc (Zn), magnesium (Mg), among other elements, and phytochemicals like phenols, flavonoids, and alkaloids, among others. Generally, the studied plant extracts exhibited significant hypoglycaemic efficacy in alloxan-induced hyperglycaemic mice, indicating their antidiabetic potential, and possess pharmacologically active phytochemicals and valuable minerals.

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Section: Discussionmentioning

confidence: 56%

In Vivo Antidiabetic Efficacy, Mineral Element Composition, and Qualitative Phytochemistry of the Aqueous Leaf Extracts of Pentas zanzibarica (Klotzsch.) Vatke and Olea europaea subspecies africana (Mill.)

Moriasi

Kibiti

Ngugi

2021

Preprint

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“…According to J. C. harborne 1998 and Arika et al [15,16], plants are known to possess various phytochemicals which are potent in ameliorating various diseases and infections such as diabetes so one could suggest that the hypoglycermic activity of the extract could be as a result of a synergistic effect of the phytochemicals inherent in the plant. Also mineral elements such as Magnesium, potassium, Calcium, Manganese, Iron, Zinc, Chromium, Copper, and Vanadium have been implicated to contribute to the antidiabetic effect of most antidiabetic medicinal plants due to their function in most metabolic pathways of the body [17], it could therefore be said that the antidiabetic properties of Axonopus compressus could be as a result of the mineral elements contained in them. Moreso, the reduction in the fasting blood glucose level in alloxan-induced diabetic rats in this study could suggest that the extract might have worked via several mechanisms such as slowing down absorption of sugar from the gut, decreasing the release of glucose by the liver, or increasing glucose uptake by the fat and muscle cells [18,19].…”

Section: Resultsmentioning

confidence: 99%

Anti-diabetic Effect of the Methanolic Leaf Extract of Axonopus compressus (P. Beauv) in Alloxan Induced Diabetic Rats

Ukegbu

Arome

Affiong

et al. 2016

IJBCRR

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Aims: This study is a preliminary step in investigating the anti-diabetic effect of the methanolic extract of the leaf of Axonopus compressus (P. Beauv) in alloxan-induced diabetic rats. Study Design/Methodology: Intraperitoneal (i.p.) injection of alloxan monohydrate at the dose of 180 mg/kg b.w was carried out to induce diabetes in the rat models. Different doses (250, 500 and 1000 mg/kg b.w.) of the extract was administered per oral through gastric gavage to the alloxan induced diabetic rats, and 2 mg/kg b.w. of glibenclamide was used as the standard drug, and only tween 20 solution (10 ml/kg) given to the negative control group. AccuCheck Active® (an autoanalyzer) glucose kit was used to assay the effects of the P. Beauv extract and the standard drug on the fasting blood glucose level at 0, 1, 3 and 6 hr(s) using the blood collected through the snip made in the tail of the rats. Results:The different doses of 250, 500 and 1000 mg/kg b.w. produced a significant (p < 0.05) reduction in the blood glucose level of the alloxan-induced diabetic animal models in the degree of

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Phytochemical composition of <i>Eriobotrya japonica</i> (Rosaceae) leaves extracts from central Veracruz, Mexico, and its effect on α-glucosidase enzyme inhibition

Infante-Rodríguez,

Aguilar-Méndez,

Landa-Cansigno

et al. 2024

Bot. Sci.

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Background: Eriobotrya japonica is economically significant as an ornamental tree, and its leaves have medicinal properties. Question: What are the main chemical components of loquat leaves grown in a population of Central Veracruz Mexico? and does the methanolic extract have potential antidiabetic properties through α-glucosidase inhibition? Species study: Eriobotrya japonica (Thunb.) Lindl. (Rosaceae) Study site and date: Xalapa, Veracruz, Mexico, 2021-2022. Methods: Total carbon (C) and nitrogen (N) content, phosphorus (P), sodium (Na), potassium (K), calcium (Ca), and magnesium (Mg) were determined in leaves powder. Leaf methanol extract of E. japonica was tested for α-glucosidase inhibition. Also, different groups of secondary metabolites were detected by the phenolics/volatile-targeted metabolomic analysis. Results: The leaves of E. japonica are rich in C and minerals such as Na, K, Ca, and Mg, and contain high levels of flavonoids, and procyanidin B2. The leaf methanol extract (LME) effectively inhibited α-glucosidase activity (86.05 ± 0.73 %) in vitro. In addition, a leaf petroleum ether extract (LPE) contains mainly phytol, palmitic acid, linoleic acid, stearic acid, and phytol acetate. Conclusions: The leaf methanolic extract exhibited antidiabetic potential due to its potent α-glucosidase inhibition, and the presence of diverse phenolic compounds, including flavonoids and their glycoside derivatives, and some fatty acids further supports the traditional use of E. japonica as an herbal medicine with antidiabetic properties.

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Mineral Elements Content of Selected Kenyan Antidiabetic Medicinal Plants

Cited by 9 publications

References 40 publications

In Vivo Antidiabetic Efficacy, Mineral Element Composition, and Qualitative Phytochemistry of the Aqueous Leaf Extracts of Pentas zanzibarica (Klotzsch.) Vatke and Olea europaea subspecies africana (Mill.)

In Vivo Antidiabetic Efficacy, Mineral Element Composition, and Qualitative Phytochemistry of the Aqueous Leaf Extracts of Pentas zanzibarica (Klotzsch.) Vatke and Olea europaea subspecies africana (Mill.)

Anti-diabetic Effect of the Methanolic Leaf Extract of Axonopus compressus (P. Beauv) in Alloxan Induced Diabetic Rats

Phytochemical composition of <i>Eriobotrya japonica</i> (Rosaceae) leaves extracts from central Veracruz, Mexico, and its effect on α-glucosidase enzyme inhibition

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