Mineral interactions in rats fed AIN-76A diets with excess calcium

Shackelford, Mary E.; Collins, T.F.X.; Black, T.N.; Ames, M.J.; Dolan, Scott P.; Sheikh, NawafKhurshid; Chi, Ruey; O’Donnell, Matthew Brook

doi:10.1016/0278-6915(94)90198-8

Cited by 16 publications

(15 citation statements)

References 24 publications

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“…Balance studies have shown pregnant rats to achieve a net gain in calcium at mid-pregnancy that is sustained to term (339). Consistent with this, an increase in femoral ash weight and calcium content has been found in rats and sheep at mid-pregnancy and term (69,629), which correlates with an increasing calcium content of the diet (818), while a progressive 10 -15% increase in total body mineral content during pregnancy has been observed by DXA in normal Black Swiss mice (296,478,827,994). However, not all studies are consistent with this since no change in femoral or tibial ash weight or calcium content was observed in several studies of rats (362,598,628,972), decreases in lumbar spine BMD by DXA and histomorphometry have been observed at mid-pregnancy and term in rats (408), and BMD of the whole body and lumbar spine decreases by DXA in C57BL/6J mice (477,580).…”

Section: Animal Datasupporting

confidence: 75%

“…Rats showed no change in whole body BMD and nonsignificant declines in BMD of femora and tibiae at the end of pregnancy (816), whereas another study found a modest but significant decline in lumbar spine BMD (920), and a third study found a gain in femoral and vertebral BMC and BMD (888). Another study found that femoral calcium content at the end of pregnancy was linearly related to the calcium content of the diet (818). Overall, apart from the serial studies in Black Swiss mice, none of the other studies in rodents can confirm or refute whether bone mass increases earlier in pregnancy before declining.…”

Section: Animal Datamentioning

confidence: 99%

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Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

383

524

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During pregnancy and lactation, female physiology adapts to meet the added nutritional demands of fetuses and neonates. An average full-term fetus contains ϳ30 g calcium, 20 g phosphorus, and 0.8 g magnesium. About 80% of mineral is accreted during the third trimester; calcium transfers at 300-350 mg/day during the final 6 wk. The neonate requires 200 mg calcium daily from milk during the first 6 mo, and 120 mg calcium from milk during the second 6 mo (additional calcium comes from solid foods). Calcium transfers can be more than double and triple these values, respectively, in women who nurse twins and triplets. About 25% of dietary calcium is normally absorbed in healthy adults. Average maternal calcium intakes in American and Canadian women are insufficient to meet the fetal and neonatal calcium requirements if normal efficiency of intestinal calcium absorption is relied upon. However, several adaptations are invoked to meet the fetal and neonatal demands for mineral without requiring increased intakes by the mother. During pregnancy the efficiency of intestinal calcium absorption doubles, whereas during lactation the maternal skeleton is resorbed to provide calcium for milk. This review addresses our current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery. Also considered are the impacts that these adaptations have on biochemical and hormonal parameters of mineral homeostasis, the consequences for long-term skeletal health, and the presentation and management of disorders of mineral and bone metabolism.

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Section: Animal Datasupporting

confidence: 75%

Section: Animal Datamentioning

confidence: 99%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

383

524

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“…Esto indicaría que una fortificación de la dieta materna con calcio durante la gestación y la lactación no produce ninguna protección en la salud ósea de la madre en condiciones no deficientes. Al igual que en nuestro estudio, Shackelford et al (21) en un estudio con ratas preñadas alimentadas con una dieta no deficiente, observó la interacción negativa entre la fortificación de la dieta con calcio durante la gestación y los niveles de otros minerales esenciales como el Fe, Zn, Mg y P (hierro, zinc, magnesio y fósforo) en diferentes tejidos. Estos resultados sugieren que una suplementación exclusiva con calcio durante la gestación y la lactancia puede no ser adecuada, puesto que podría generar una disfunción en el metabolismo de otros minerales esenciales que son importantes tanto para la salud materna como para el desarrollo de la cría.…”

Section: Discussionunclassified

Influencia del suplemento con inulina enriquecida con fructooligosacáridos sobre el contenido y la densidad mineral ósea tras el parto y la lactación en ratas

et al. 2016

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I, López Pedrosa JM. Infl uencia del suplemento con inulina enriquecida con fructooligosacáridos sobre el contenido y la densidad mineral ósea tras el parto y la lactación en ratas. Nutr Hosp 2016;33:1074-1081 DOI: http://dx.doi.org/10.20960/nh.569Infl uencia del suplemento con inulina enriquecida con fructooligosacáridos sobre el contenido y la densidad mineral ósea tras el parto y la lactación en ratas AbstractIntroduction: Pregnancy and lactation are related with temporary decreases in maternal bone mineral density (BMD). Calcium supplementation could be benefi cial to prevent bone loss of maternal skeleton. Other nutrients, such as prebiotics have showed to produce an increase of the mineral absorption and therefore affecting bone mineralization. Objective: To study the effect of maternal diet supplementation with prebiotic oligofructose-enriched inulin during gestation and lactation on the maternal bone mineral content (BMC) and BMD at the end of lactation. Methods: Pregnant rats were fed with standard diet (CC group), calcium fortifi ed diet (Ca group) or with prebiotic oligofructose-enriched inulin supplemented diet until the end of the lactation period. At weaning, bone mineral content (BMC) and BMD were determined by dual-energy X-ray absorptiometry and the pH of the cecal content was also determined. Results: In absolute terms, the highest BMD and BMC were found in the Pre group as compared with the other two groups being signifi cant in the tibia when compared Pre group and CC group with Ca group. The pH of the cecal content in the Pre group was also signifi cantly lower as compared with the other two groups. Conclusion: Prebiotic oligofructose-enriched inulin supplementation, in calcium no-defi cient conditions, during gestation and lactation exerts a protection on maternal skeleton during pregnancy and lactation in the rats and could be considered as a plausible nutritional option for protecting maternal bone mass during these periods.

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“…However, excessive Ca intake may have adverse effects on the metabolism of other micronutrients. In this sense, Ca supplementation can inhibit the absorption of Fe (Barton et al 1983) perhaps due to previously reported Ca-Cu interactions (Shackelford et al 1994). Dietary Cu is required for the efficient utilization of dietary Fe.…”

Section: Introductionmentioning

confidence: 94%

“…These findings could be due to the nutritional characteristics of the goat's milk (Barrionuevo et al 2002) minimizing Ca-Cu interactions (Shackelford et al 1994), even though the dietary Ca content was double that required for the rat.…”

Section: Digestive and Metabolic Utilization Of Cumentioning

confidence: 99%

Effect of calcium-fortified milk-rich diets (either goat’s or cow’s milk) on copper bioavailability in iron-deficient anemia

Díaz-Castro¹,

Alférez²,

López-Áliaga³

et al. 2011

Dairy Science & Technol.

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Mineral interactions in rats fed AIN-76A diets with excess calcium

Cited by 16 publications

References 24 publications

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Influencia del suplemento con inulina enriquecida con fructooligosacáridos sobre el contenido y la densidad mineral ósea tras el parto y la lactación en ratas

Effect of calcium-fortified milk-rich diets (either goat’s or cow’s milk) on copper bioavailability in iron-deficient anemia

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