Mineral Metabolism in Health and Disease

Tubular Disorders of Acid-Base and Phosphate Metabolism

“…Active transport is likely to be under the control of vitamin D. Although intestinal secre tion of phosphate is a potential route of loss in certain disorders, the major route of excretion of phosphate is via the kidneys [37,38]. Renal excretion of phosphate is dependent on dietary intake with final regulation modu lated by parathyroid hormone action at the renal tubule [39][40][41], Metabolic studies have demonstrated that although 80% of a 1,200 mg daily phosphate intake is absorbed, urinary excretion and fecal losses neatly balance the intake.…”