Mineral Trioxide Aggregate—A Review of Properties and Testing Methodologies

Ha, William Nguyen; Nicholson, Timothy M.; Kahler, Bill; Walsh, L. J.

doi:10.3390/ma10111261

Cited by 48 publications

(59 citation statements)

References 104 publications

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“…Despite the high clinical advantages of MTA cement, there were always some limitations which prevented clinicians from using it in on a daily basis. The major ones being a long setting time (up to 284 min) [44,64], handling difficulties, discoloration of the remaining tooth structure [65] and the presence of heavy metals in the powder [66]. The aforementioned properties of MTA are listed in Tables 1 and 2.…”

Section: Mineral Trioxide Aggregatementioning

confidence: 99%

Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article

2020

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The article is aimed at analyzing the available research and comparing the properties of bio-inductive materials in direct and indirect pulp capping procedures. The properties and clinical performances of four calcium-silicate cements (ProRoot MTA, MTA Angelus, RetroMTA, Biodentine), a light-cured calcium silicate-based material (TheraCal LC) and an enhanced resin-modified glass-ionomer (ACTIVA BioACTIVE) are widely discussed. A correlation of in vitro and in vivo data revealed that, currently, the most validated material for pulp capping procedures is still MTA. Despite Biodentine's superiority in relatively easier manipulation, competitive pricing and predictable clinical outcome, more long-term clinical studies on Biodentine as a pulp capping agent are needed. According to available research, there is also insufficient evidence to support the use of TheraCal LC or ACTIVA BioACTIVE BASE/LINER in vital pulp therapy.

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Section: Mineral Trioxide Aggregatementioning

confidence: 99%

Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article

2020

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“…Herein, the addition of 4 and 20% of MTA into PCL increased the rate of degradation by almost 2.5 and 4 times, respectively (Table 3 and Levels 2 and 3 in Figure 3). It is likely that MTA increases hydrophilicity of the scaffold and make it more prone to degradation (Ha, Nicholson, Kahler, & Walsh, 2017).…”

Section: Discussionmentioning

confidence: 99%

Taguchi's methods to optimize the properties and bioactivity of 3D printed polycaprolactone/mineral trioxide aggregate scaffold: Theoretical predictions and experimental validation

et al. 2019

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Mineral trioxide aggregate (MTA) can provide bioactivity to poly‐caprolactone (PCL), which is an inert polymer used to print scaffolds. However, testing all combinations of scaffold characteristics (e.g., composition, pore size, and distribution) to optimize properties of scaffolds is time‐consuming and costly. The Taguchi's methods can identify characteristics that have major influences on the properties of complex designs, hence decreasing the number of combinations to be tested. The objective was to assess the potential of Taguchi's methods as a predictive tool for the optimization of bioactive scaffold printed using electro‐hydro dynamic jetting. A three‐level approach assessed the influence of PCL/MTA proportion, pore size, fiber dimension and number of layers in pH, degradation rate, porosity, yield strength, and Young's modulus. Data were analyzed using Tukey's honest significant difference test, analysis of mean and signal‐to‐noise ratio (S/N) test. Cytocompatibility and differentiation potential were assessed for 5 and 30 days using dental pulp stem cells and analyzed with one‐way analysis of variance (proliferation) or Mann–Whitney (qPCR). The S/N ratio and analysis of mean showed that fiber diameter and composition were the most influential characteristics in all properties. The experimental data confirmed that the addition of MTA to PCL increased the pH and scaffold degradation. Only PCL and PCL with 4% MTA allowed cell proliferation. The latter increased the genetic expression of ALP, COL‐1, OCN, and MSX‐1. The theoretical predictions were confirmed by the experiments. The Taguchi's identified the inputs that can be disregarded to optimize 3D printed meshed bioactive scaffolds.

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“…Hydraulic calcium silicate restoratives based upon Portland cement and its constituent dicalcium and tricalcium silicate phases are popular options for many endodontic procedures involving hard tissue repair and pulpal regeneration [1,2]. The properties and clinical applications of the current range of endodontic calcium silicate cements are extensively reported and reviewed in the recent scientific literature [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…ISO 6876:2001 [8] and ANSI/ADA specification #57 [9] respectively stipulate that endodontic materials are required to possess a minimum radiopacity of 3 mm Al and a differential value of at least 2 mm Al between the cement and cortical bone. In order for commercial calcium silicate-based cements to comply with these standards, unreactive heavy metal oxide powders (such as Bi 2 O 3 , Zr 2 O, Ta 2 O 5 , Nb 2 O 5 , BaZrO 3 ) are typically dry-blended into the formulation to achieve acceptable radiopacity [1][2][3][4][5][6][7]. Other candidate radiopacifiers (including CHI 3 , BaSO 4 , TiF 4 , CaWO 4 , Yb 2 O 3 , YbF 3 ) have also been reported for experimental cements [10][11][12][13][14][15]; although, to date, the most commonly employed radiopacifying agents are bismuth (III) oxide (monoclinic α-Bi 2 O 3 ) and zirconium (IV) oxide (monoclinic Zr 2 O) [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Bi2O3 and ZrO2 Radiopacifiers on the Early Hydration and C–S–H Gel Structure of White Portland Cement

Coleman

2019

JFB

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Bismuth oxide (monoclinic α-Bi2O3) and zirconium oxide (monoclinic ZrO2) are the most popular radiopacifiers in commercial Portland cement-based endodontic restoratives, yet their effects on the setting and hydration reactions are not fully understood. This study compares the impact of 20 wt.% of Bi2O3 or ZrO2 on the early hydration reactions and C–S–H gel structure of white Portland cement (WPC). Cement paste samples were hydrated at 37.5 °C prior to analysis by 29Si and 27Al magic angle spinning nuclear magnetic resonance spectroscopy at 3 h and 24 h, and transmission electron microscopy at 3 h. Initial and final setting times were determined using a Vicat apparatus and reaction kinetics were monitored by isothermal conduction calorimetry. Bi2O3 was found to prolong initial and final setting times and retard the degree of hydration by 32% at 24 h. Heat evolution during the acceleration and deceleration phases of the hydration process was reduced and the exotherm arising from renewed ettringite formation was delayed and diminished in the presence of Bi2O3. Conversely, ZrO2 had no significant impact on either setting time; although, it accelerated hydration by 23% within 24 h. Increases in the mean silicate chain length and the extent of aluminum substitution in the C–S–H gel were observed in the presence of both radiopacifying agents after 24 h relative to those of the unblended WPC. The Bi2O3 and ZrO2 particles remained intact within the cement matrix and neither bismuth nor zirconium was chemically incorporated in the hydration products.

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Mineral Trioxide Aggregate—A Review of Properties and Testing Methodologies

Cited by 48 publications

References 104 publications

Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article

Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article

Taguchi's methods to optimize the properties and bioactivity of 3D printed polycaprolactone/mineral trioxide aggregate scaffold: Theoretical predictions and experimental validation

Impact of Bi2O3 and ZrO2 Radiopacifiers on the Early Hydration and C–S–H Gel Structure of White Portland Cement

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