Mini Review on Antimicrobial Activity and Bioactive Compounds of Moringa oleifera

Wang, Lei; Chen, Xiaoyang; Wu, Ai-Min

doi:10.4172/2161-0444.1000402

Cited by 39 publications

(32 citation statements)

References 47 publications

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“…Antimicrobial properties are possibly attributed by 4‐(α‐ l ‐rhamnopyranosyloxy)benzyl isothiocyanate, methyl N‐4‐(α‐ l ‐rhamnopyranosyloxy)benzyl carbamate and 4‐(β‐ d ‐glucopyranosyl‐1 → 4‐α‐ l ‐rhamnopyranosyloxy)‐benzyl thiocarboxamide (Oluduro, Aderiye, Connolly, Akintayo, & Famurewa, ; Padla et al, ); water soluble lectine protein (Coelho et al, ; Ferreira et al, ; Moura et al, ); flocculating cationic polypeptides (Shebek et al, ); niazimicin (Rim et al, 2014); glycosides 4‐(α‐ l ‐rhamnosyloxy)‐benzyl isothiocyanate, 4‐(α‐ l ‐rhamnosyloxy)‐phenylacetonitrile and moringine (Jahn, Musnad, & Burgstaller, ); proanthocyanidins (Maldini et al, ) in seeds; niaziminin, niazinin (Wang, Chen, & Wu, ), and silver nanoparticles (Prasad & Elumalai, ) in leave extract; cardiac glycosides in pods (Arora & Onsare, ); kaempferol, rhamnetin, kaempferitin, isoquercitrin, and pterygospermin in flowers; spirochin and anthonine in roots (Farooq, Rai, Tiwari, Khan, & Farooq, ; Mehta, Shukla, Bukhariya, & Charde, ; Raj, Gopalakrishnan, Yadav, & Dorairaj, ); and aglycon of deoxy‐niazimicine (N‐benzyl, S‐ethyl thioformate) in bark (Nikkon et al, ). It is cleared from previous studies that seeds may also act directly upon microorganisms and showed broader antimicrobial spectrum than other parts of MO.…”

Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

178

100

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The genus Moringa Adans. comprises 13 species, of which Moringa oleifera Lam. native to India and cultivated across the world owing to its drought and frost resistance habit is widely used in traditional phytomedicine and as rich source of essential nutrients. Wide spectrum of phytochemical ingredients among leaf, flower, fruit, seed, seed oil, bark, and root depend on cultivar, season, and locality. The scientific studies provide insights on the use of M. oleifera with different aqueous, hydroalcoholic, alcoholic, and other organic solvent preparations of different parts for therapeutic activities, that is, antibiocidal, antitumor, antioxidant, anti‐inflammatory, cardio‐protective, hepato‐protective, neuro‐protective, tissue‐protective, and other biological activities with a high degree of safety. A wide variety of alkaloid and sterol, polyphenols and phenolic acids, fatty acids, flavanoids and flavanol glycosides, glucosinolate and isothiocyanate, terpene, anthocyanins etc. are believed to be responsible for the pragmatic effects. Seeds are used with a view of low‐cost biosorbent and coagulant agent for the removal of metals and microbial contamination from waste water. Thus, the present review explores the use of M. oleifera across disciplines for its prominent bioactive ingredients, nutraceutical, therapeutic uses and deals with agricultural, veterinarian, biosorbent, coagulation, biodiesel, and other industrial properties of this “Miracle Tree.”

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Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

178

100

View full text Add to dashboard Cite

show abstract

“…Moringa oleifera, local name is Sonjna, belongs to family Moringaceae and is an effective antiviral agent used against Epstein-Barr virus (EBV), herpes simplex virus (HSV), HIV/AIDS, and hepatitis B virus [26]. The anti-FMDV activity of ethanolic leaves extract of Moringa oleifera was evaluated at different concentrations, respectively (200, 100, 50, 25, 12, 6, and 1 μg/ml), on BHK-21 cell culture.…”

Section: Plants For Treatment Of Fmdvmentioning

confidence: 99%

Foot-and-Mouth Disease Virus (FMDV) and Its Treatment with Plant Extracts

Younus¹,

Maqbool²,

Khan³

et al. 2020

Veterinary Medicine and Pharmaceuticals

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Foot-and-mouth disease (FMD) is a contagious viral infection which is caused by foot-and-mouth disease virus (FMDV). The disease appears in cloven-footed animals. Symptoms of the disease are abrupt manifestation of sores on the mouth, nose, feet, etc. Nowadays the control and treatment of FMDV are becoming a worldwide economic problem and challenge for the society. Currently, there is no particular treatment available for FMDV, as well as the limitations and disadvantages in the use of vaccines divert the focus of researchers toward natural sources like plant extracts which possess potential antiviral activity. Various researches documented in the literature demonstrated various plant extracts with antiviral potency against FMDV. In the current chapter, we discussed about FMDV and its possible treatment with plant extracts.

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“…Medicinal plants are valuable sources of antifungal compounds. Moringa oleifera is a precious source of bioactive compounds with different pharmacological activities 17 . Extracts of M. oleifera reportedly have potential antifungal activities against dermatophytic fungi 18 with good remedial properties and few side effects as compared with synthetic antibiotics 19 .…”

Section: Introductionmentioning

confidence: 99%

Bioactivities of Anethole, Astragalin and Cryptochlorogenic Acid Extracted from Anise Oil and Moringa oleifera on the Keratinase Gene Expression of Trichophyton rubrum

Obaid¹,

Al-Janabi²,

Taj-Aldin³

2020

J. Pure Appl. Microbiol.

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Trichophyton rubrum is the most common cause of dermatophyte skin infections in humans worldwide. The aim of the current study is to search for effective and safe antifungal agents by investigating the bioactivity of Pimpinella anisum and Moringa oleifera extracts, including the impact on the keratinase gene expression of T. rubrum. Astragalin and cryptochlorogenic acid were detected in M. oleifera leaf extracts by Gas chromatography-mass spectrometry (GC-MS), whereas anethole was extracted from P. anisum oil. The expression of the keratinase gene was assessed in two strains of T. rubrum (KP979791 and KP979787) in Sabouraud Dextrose Broth (SDB) medium (containing 10% keratin) separately supplemented with plant extracts fractions. The results showed that cryptochlorogenic acid and astragalin were active compounds (molecular weights of 353.26 and 449.35 g/mol, respectively that considerably down-regulated the keratinase genes in both strains of T. rubrum. M. oleifera crude extract, astragalin, cryptochlorogenic acid, anise oil, and anethole resulted in the down-regulation of the keratinase genes of T. rubrum strain KP979791 by 0.048, 0.291, 0.001, 0.007, and 0.009 (foldchange), respectively, and that of strain KP979787 by 0.151, 0.42, 0.16, 0.079, and 0.092 as compared to the control (1.00). Nearly all of these outcomes are novel findings that may aid in the identification of novel effective drug targets and antifungal agents.

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Mini Review on Antimicrobial Activity and Bioactive Compounds of Moringa oleifera

Cited by 39 publications

References 47 publications

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Foot-and-Mouth Disease Virus (FMDV) and Its Treatment with Plant Extracts

Bioactivities of Anethole, Astragalin and Cryptochlorogenic Acid Extracted from Anise Oil and Moringa oleifera on the Keratinase Gene Expression of Trichophyton rubrum

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