Miniature Endoscope for Multimodal Imaging

Dai, Xianjin; Yang, Hao; Shan, Tianqi; Xie, Huikai; Berceli, Scott A.; Jiang, Huabei

doi:10.1021/acsphotonics.6b00852

Cited by 51 publications

(46 citation statements)

References 47 publications

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“…The multimodal endoscopic probe with a size of 1 mm in diameter described in detail before [35] was used to directly reach the surface of the pancreas through a hole in the abdomen of mouse. Here, photoacoustic imaging was performed first, followed by fluorescence imaging.…”

Section: Miniaturized Endoscopic Imaging System and Scanning Mechanismmentioning

confidence: 99%

Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope

et al. 2017

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It is highly desirable to develop novel approaches to improve patient survival rate of pancreatic cancer through early detection. Here, we present such an approach based on photoacoustic and fluorescence molecular imaging of pancreatic tumor using a miniature multimodal endoscope in combination with targeted multifunctional iron oxide nanoparticles (IONPs). A novel fan-shaped scanning mechanism was developed to minimize the invasiveness for endoscopic imaging of pancreatic tumors. The results show that the enhancements in photoacoustic and fluorescence signals using amino-terminal fragment (ATF) targeted IONPs were~four to six times higher compared to that using non-targeted IONPs. Our study indicates the potential of the combination of the multimodal photoacoustic-fluorescence endoscopy and targeted multifunctional nanoparticles as an efficient tool to provide improved specificity and sensitivity for pancreatic cancer detection.

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Section: Miniaturized Endoscopic Imaging System and Scanning Mechanismmentioning

confidence: 99%

Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope

et al. 2017

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“…[36][37][38][39] IV-PA is also regularly integrated with other popular endoscopic imaging modalities such as IVUS and OCT in order to further improve its imaging capability. [40][41][42][43] Especially, coregistration with IVUS is very easy to implement as IV-PA and IVUS share the same endoscopic transducer.…”

Section: Introduction: Atherosclerosis and Conventional Imaging Modalmentioning

confidence: 99%

“…Many other designs utilize an angled mirror or a prism to direct the beam to an arterial wall and implement an optically transparent acoustic mirror to transmit generated acoustic signals back to a transducer in a catheter. 42,56,57 Lastly, some other popular designs employ a transducer with a hole at the center (ringshaped). 40,41,58 In this case, the laser beam is directed through the hole so that the travel paths of light and sound are overlapped as much as possible while compromising detection sensitivity of the transducer to some extent.…”

Section: Introduction: Atherosclerosis and Conventional Imaging Modalmentioning

confidence: 99%

“…For optical collimating and focusing purposes, some catheter designs incorporate small optics inside. A graded-index (GRIN) lens and an aspheric lens are typical choices to achieve stationary focusing 42,57 while a use of a liquid lens was recently reported for dynamic focusing. 58 For mechanical rotation of a catheter, a flexible torque cable and a rotary motor are usually employed.…”

Section: Introduction: Atherosclerosis and Conventional Imaging Modalmentioning

confidence: 99%

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Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations

Choi

Mandelis

2019

J. Biomed. Opt.

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Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations," J.Abstract. Intravascular photoacoustics (IV-PA) is an emerging atherosclerosis imaging modality that provides chemical-specific optical information of arterial walls with acoustic depth penetration and resolution. As lipid composition of atherosclerotic plaques is considered to be one of the primary indicators for plaque vulnerability, many IV-PA applications are calibrated so as to target plaque necrotic cores. Based on the mode of optical excitation and the corresponding signal processing technique, IV-PA is categorized into two different modalities. The pulse-based IV-PA has been the universal IV-PA imaging mode with its high peak power and straightforward time-domain signal processing technique. As an alternative, the low power continuous-wave (CW)-based IV-PA has been under intense development as a radar-like frequency-domain signal processing modality. The two state-of-the-art types of IV-PA are reviewed in terms of their physics and imaging capabilities, with major emphasis on frequency-swept CW-based IV-PA that has been recently introduced in the field. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Emerging techniques, including 2‐photon microscopy (TPM) and photoacoustic imaging (PAI) , are capable of providing very high resolution imaging of biological tissue as well as cerebral hemodynamics. However, these techniques have the drawbacks of limited imaging penetration depth and are inadequate for in vivo imaging of human subject with intact skull.…”

Section: Introductionmentioning

confidence: 99%

Fast noninvasive functional diffuse optical tomography for brain imaging

Dai

Zhang

Yang

et al. 2017

Journal of Biophotonics

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Advances in epilepsy studies have shown that specific changes in hemodynamics precede and accompany seizure onset and propagation. However, it has been challenging to noninvasively detect these changes in real time and in humans, due to the lack of fast functional neuroimaging tools. In this study, we present a functional diffuse optical tomography (DOT) method with the guidance of an anatomical human head atlas for 3-dimensionally mapping the brain in real time. Central to our DOT system is a human head interface coupled with a technique that can incorporate topological information of the brain surface into the DOT image reconstruction. The performance of the DOT system was tested by imaging motor tasks-involved brain activities on N = 6 subjects (3 epilepsy patients and 3 healthy controls). We observed diffuse areas of activations from the reconstructed [HbT] images of patients, relative to more focal activations for healthy subjects. Moreover, significant pretask hemodynamic activations were also seen in the motor cortex of patients, which indicated abnormal activities persistent in the brain of an epilepsy patient. This work demonstrates that fast functional DOT is a valuable tool for noninvasive 3-dimensional mapping of brain hemodynamics.

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Miniature Endoscope for Multimodal Imaging

Cited by 51 publications

References 47 publications

Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope

Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope

Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations

Fast noninvasive functional diffuse optical tomography for brain imaging

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