Miniaturized system of neurotrophin patterning for guided regeneration

Yu, Laura M.Y.; Wosnick, Jordan H.; Shoichet, Molly S.

doi:10.1016/j.jneumeth.2008.03.023

Cited by 34 publications

(33 citation statements)

References 43 publications

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“…42 Other examples include research on in vitro outgrowth of neurites on polymer filaments, with different shapes and coatings 56 ), and polymer surfaces patterned with gradients of peptides or neurotrophic factors to guide neurites in a certain direction. 71 Only a limited number of studies have investigated the influence on in vivo nerve regeneration. Below we discuss several physical and molecular guidance strategies that may be applied in future nerve repair, and we also discuss our own experience with in vivo axonal guidance in which multichannel nerve tubes and gene therapy are used.…”

Section: In Vivo Guidance Of Regenerating Axonsmentioning

confidence: 99%

Misdirection and guidance of regenerating axons after experimental nerve injury and repair

Ruiter

Spinner

Verhaagen

et al. 2014

JNS

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Misdirection of regenerating axons is one of the factors that can explain the limited results often found after nerve injury and repair. In the repair of mixed nerves innervating different distal targets (skin and muscle), misdirection may, for example, lead to motor axons projecting toward skin, and vice versa-that is, sensory axons projecting toward muscle. In the repair of motor nerves innervating different distal targets, misdirection may result in reinnervation of the wrong target muscle, which might function antagonistically. In sensory nerve repair, misdirection might give an increased perceptual territory. After median nerve repair, for example, this might lead to a dysfunctional hand.Different factors may be involved in the misdirection of regenerating axons, and there may be various mechanisms that can later correct for misdirection. In this review the authors discuss these different factors and mechanisms that act along the pathway of the regenerating axon. The authors review recently developed evaluation methods that can be used to investigate the accuracy of regeneration after nerve injury and repair (including the use of transgenic fluorescent mice, retrograde tracing techniques, and motion analysis). In addition, the authors discuss new strategies that can improve in vivo guidance of regenerating axons (including physical guidance with multichannel nerve tubes and biological guidance accomplished using gene therapy). 493Abbreviations used in this paper: BDNF = brain-derived neurotrophic factor; DY = diamidino yellow; FB = fast blue; GC = growth cone; GDNF = glial cell line-derived neurotrophic factor; LV = lentiviral vector; NGF = nerve growth factor.

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Section: In Vivo Guidance Of Regenerating Axonsmentioning

confidence: 99%

Misdirection and guidance of regenerating axons after experimental nerve injury and repair

Ruiter

Spinner

Verhaagen

et al. 2014

JNS

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“…Yuan et al also reported that chitosan membranes and fibers have excellent neuroglial cell affinity and good biological compatibility. SCs grown on chitosan membranes displayed a spherical shape, whereas on chitosan fibers, they had an elongated morphology (Yuan et al, 2004). Yet, reported that a chitosan nonwoven nanofiber mesh tube with an inner layer of oriented nanofibers, produced by electrospinning method, induced alignment of immortalized adult mouse SCs (IMS32).…”

Section: Chitosan Biocompatibilitymentioning

confidence: 99%

“…When nervous tissue loss occurs, different methods have been used to bridge the spinal cord gap. For example, transplantation of peripheral nerves (Bray, Villegas-Perez, Vidal-Sanz, & Aguayo, 1987;Cheng, Cao, & Olson, 1996), SCs (Bunge, 2002;Novikova, Pettersson, Brohlin, Wiberg, & Novikov, 2008;Xu, Zhang, Li, Aebischer, & Bunge, 1999), olfactory ensheathing cells (Li, Field, & Raisman, 1997;Ramon-Cueto, Plant, Avila, & Bunge, 1998), and NSCs has been used (Teng et al, 2002;Xue et al, 2012;Zheng & Cui, 2012). These studies have shown that CNS axons can regenerate in an appropriate microenvironment and injured axons can recover part of their function.…”

Section: Chitosan For Central Nervous System Repairmentioning

confidence: 99%

“…BMSC-derived SCs have been used in combination with chitosan conduits to repair 12-mm rat sciatic nerve gap, resulting in nerve conduction velocities, average regenerated myelin area, and number of myelinated axons similar to those conduits treated with sciatic nerve-derived SCs (Ao et al, 2011). Chitosan-based conduits combined with autologous BMSCs have been successfully utilized to bridge 8-mm-long sciatic nerve defects in adult rats (Zheng & Cui, 2012). Chitosan/PLGA-based neuronal scaffolds, in which autologous BMSCs have been incorporated, promoted dog sciatic nerve regeneration and functional recovery across 50-to 60-mm-long gaps.…”

Section: Chitosan Conduits Combined With Cells For Pns Repairmentioning

confidence: 99%

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The Use of Chitosan-Based Scaffolds to Enhance Regeneration in the Nervous System

Gnavi

Barwig²,

Freier³

et al. 2013

International Review of Neurobiology

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Various biomaterials have been proposed to build up scaffolds for promoting neural repair. Among them, chitosan, a derivative of chitin, has been raising more and more interestamongbasicandclinicalscientists.Anumberofstudieswithneuronalandglial cellcultures haveshownthat thisbiomaterial has biomimetic properties,which make it a good candidate for developing innovative devices for neural repair. Yet, in vivo experimental studies have shown that chitosan can be successfully used to create scaffolds that promote regeneration both in the central and in the peripheral nervous system. In this review, the relevant literature on the use of chitosan in the nervous tissue, either alone or in combination with other components, is overviewed. Altogether, the promising in vitro and in vivo experimental results make it possible to foresee that time for clinicaltrialswithchitosan-basednerveregenerationpromotingdevicesisapproaching quickly.

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“…Compared with physical adsorption, a higher concentration of growth factors was obtained via immobilization [69]. Instead of compromising the bioactivity, immobilization in fact increased the efficacy of growth factors [57]. It was reported that immobilization of vascular endothelial growth factor (VEGF) outperformed in cell adhesion and viability even at a much lower concentration compared with soluble VEGF [70].…”

Section: Delivery Of Neurotrophic Factorsmentioning

confidence: 99%

Hyaluronic acid-based scaffold for central neural tissue engineering

Wang

et al. 2012

Interface Focus.

129

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Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell-and regenerationactivating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.

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Miniaturized system of neurotrophin patterning for guided regeneration

Cited by 34 publications

References 43 publications

Misdirection and guidance of regenerating axons after experimental nerve injury and repair

Misdirection and guidance of regenerating axons after experimental nerve injury and repair

The Use of Chitosan-Based Scaffolds to Enhance Regeneration in the Nervous System

Hyaluronic acid-based scaffold for central neural tissue engineering

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