Minimal surfaces and structures: from inorganic and metal crystals to cell membranes and biopolymers

Andersson, Sten; Hyde, Stephen T.; Larsson, Kåre; Lidin, Sven

doi:10.1021/cr00083a011

Cited by 315 publications

(254 citation statements)

References 20 publications

Supporting

Mentioning

241

Contrasting

Order By: Relevance

“…But the most interesting structures observed in our work are triply periodic continuous minimal surfaces, which can be seen when the porous particle obtained in methanol/toluene solutions are fractured. The morphology is analogous to those theoretically proposed by Schwarz 25 and Schoen 26 with total mean curvature close to zero 27 . The structures are known as Schwarz P and Schoen Gyroid, as shown in Fig.…”

Section: Preparation and Characterization Of Nanoporous Particlessupporting

confidence: 84%

Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

et al. 2014

View full text Add to dashboard Cite

The design of micro-or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances.

show abstract

Section: Preparation and Characterization Of Nanoporous Particlessupporting

confidence: 84%

Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In general, the difference of the chemical potential of the phospholipid membrane in the H II phase (µ HII ) and in the bilayer liquid crystalline (L α ) phase (µ bil ), µ, can be expressed as a sum of the curvature elastic energy ( µ curv ) and the acyl chain packing energy ( µ ch ) [25,28]. The curvature energy can be expressed as [29,30] …”

Section: Discussionmentioning

confidence: 99%

“…Equation (2) shows that µ curv is always negative ( µ curv < 0), and thereby, is an important factor stabilizing the H II phase. On the other hand, in the H II phase, acyl chains of lipids have to extend to different lengths to fill the interstitial hydrocarbon region, which decreases the entropy of chains and thereby increases the free energy of the membrane [28]. Therefore, this packing energy of the acyl chains unstabilizes the H II phase, and thus, µ ch is always positive ( µ ch > 0).…”

Section: Discussionmentioning

confidence: 99%

Low pH Stabilizes the Inverted Hexagonal II Phase in Dipalmitoleoylphosphatidylethanolamine Membrane

Yamazaki

2004

J Biol Phys

View full text Add to dashboard Cite

Abstract. Dipalmitoleoylphosphatidylethanolamine (DPOPE) membrane is in the L α phase in neutral pH at 20 • C. The results of small-angle X-ray scattering (SAXS) indicate that an L α to H II phase transition in DPOPE membranes occurred at pH 1.9 in the absence of salt, and at pH 2.8 in the presence of 0.5 M KCl, at fully hydrated condition at 20 • C. The spontaneous curvature of DPOPE monolayer membrane did not change with a decrease in pH values. To elucidate the mechanism, we have investigated the effect of the cationic dioctadecyldimethylammonium (DODMA) on the structure and phase behavior of DPOPE membrane. The result shows that DODMA stabilizes the H II phase rather than the L α phase in DPOPE membrane at its low concentrations. Based on these results, the H II phase stability of DPOPE membrane due to low pH is discussed in terms of the spontaneous curvature of the monolayer membrane and the packing energy of acyl chains in the membrane.

show abstract

“…A more complete understanding the phase behavior of these complex materials could lead to a new paradigm in the design of novel materials. Of great scientific and technological interest is a particular kind of mesophase based in minimal surfaces, known as the ordered bicontinuous phases, 10 where the minority component forms two triply-periodic interweaving networks that never intersect (see Fig. 1), making them ideal candidates as precursor of: porous materials, 11,12 regular three-dimensional networks, and highconductivity nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

Final Report: Grant DE-FG02-05ER15682. Simulation of Complex Microphase Formation in Pure and Nanoparticle-filled Diblock Copolymers

Escobedo¹

2009

View full text Add to dashboard Cite

SummaryThe goal of this project was to use molecular simulation to quantify the impact of additives on the onset and structure of bicontinuous phases in linear diblock copolymers (DBC). The focus was on understanding how additives with selective affinity for a given block will distribute and perturb the structure of complex bicontinuous phases (like gyroid, double diamond, and plumbers nightmare whose minority component block forms two interweaving 3D networks) in DBCs; it was hypothesized that a suitable choice of additive type, size, affinity, and concentration may suppress or stabilize a particular bicontinuous phase. The ultimate goal in this line of investigation is to elucidate the rational design of the optimal additive for which the composition range of stability of a particular bicontinuous phase is maximized. Ours are the first published simulation studies to report on the formation of the gyroid phase in DBC melts and of other bicontinuous phases in DBC-modified by homopolymer.The following tasks were carried out: (i) simulation of bicontinuous phases of pure DBCs via both on-lattice Monte Carlo simulations and continuum-space Monte Carlo and molecular dynamics simulations, (ii) determination of the effect of selective additives (homopolymer) of different sizes on such bicontinuous phases, and (iii) development of novel Monte Carlo methods to map out reliable phase diagrams and improve ergodic sampling; in particular, optimized expanded-ensemble techniques for measuring free-energies and for chemical potential equilibration.

show abstract

Minimal surfaces and structures: from inorganic and metal crystals to cell membranes and biopolymers

Cited by 315 publications

References 20 publications

Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

Low pH Stabilizes the Inverted Hexagonal II Phase in Dipalmitoleoylphosphatidylethanolamine Membrane

Final Report: Grant DE-FG02-05ER15682. Simulation of Complex Microphase Formation in Pure and Nanoparticle-filled Diblock Copolymers

Contact Info

Product

Resources

About