Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes

Oliveira, João; Sevanian, Alex; Rodrigues, Ricardo José; Apolinário, Elaine; Abdalla, Dulcinéia Saes Parra

doi:10.1016/j.clinbiochem.2006.05.002

Cited by 46 publications

(38 citation statements)

References 55 publications

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“…MDA levels were determined by the TBARs spectrophotometric test (Esterbauer & Cheeseman 1990). Antibodies against mildly oxidized low-density lipoproteins (LDL -) and native LDL (nLDL) were determined by enzyme-linked immunosorbent assay according to Oliveira et al (2006) and expressed as LDL -/nLDL autoantibody ratios. Nitrite/ Nitrate concentrations were measured by chemiluminescence in the gas phase (NOA 280 ® , Sievers, Boulder, CO, USA) after reduction with acidic vanadium (III) chloride.…”

Section: Markers Of Os and Antioxidant Status -mentioning

confidence: 99%

The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria

Araujo

Lacerda

Abdalla

et al. 2008

Mem. Inst. Oswaldo Cruz

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Section: Markers Of Os and Antioxidant Status -mentioning

confidence: 99%

The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria

Araujo

Lacerda

Abdalla

et al. 2008

Mem. Inst. Oswaldo Cruz

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“…Martino et al (12) showed that already in children oxidative stress may have an important role in the occurrence of premature atherosclerosis. In this context, electronegative low-density lipoprotein [LDL (2)] has been widely monitored in adults and now it is considered a potential biomarker associated with initiation and progression of atherosclerosis (13)(14)(15)(16). Despite these observations, a limited number of studies have detected LDL (2) in children and adolescents (17,18).…”

mentioning

confidence: 99%

Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?

Silva

Mello

Sanches

et al. 2013

J Nutr Sci Vitaminol

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Summary Obesity has increased in children and adolescents. What is reflected in the early occurrence of cardiometabolic alterations, like hypertension and type 2 diabetes, where the oxLDL formation is stimulated. Various studies have shown that plasma a-tocopherol (a-TP) can protect LDL against oxidation. Nevertheless, the action of plasma a-TP in cardiovascular diseases remains controversial. We conducted a cross-sectional study to evaluate plasma a-TP and its impact on the concentration of LDL(2). Adolescents (n5150) of both sexes were classified into three groups: healthy weight (HW; 50%), overweight (OV; 22%), and obese (OB; 28%). Lipid profile, LDL(2), anti-oxLDL and anti-LDL(2) antibodies, CRP (ELISA) and plasma a-TP (HPLC) were analyzed. Demographic, anthropometric, and food intake data were evaluated. Crude and energy-adjusted intake of vitamin E in the OB group were higher than in the HW group (p,0.001). Crude and energy-adjusted vitamin E intakes were not correlated with plasma a-TP (r520.07; p50. 412 and r520.064; p50.467, respectively). Subjects in the OB group had higher TC and LDL-C and lower HDL-C than in the HW and OV groups. C-reactive protein and anti-oxLDL antibodies changed as a function of BMI. The impact of obesity was reinforced by high values for LDL(2) and low content of plasma a-TP in comparison with the HW (p,0.001) and OV groups (p50.03). This negative profile was maintained for the ratio between a-TP and TC or LDL-C. Plasma a-TP, a-TP/TC and a-TP/LDL-C were negatively associated with LDL(2) and other cardiometabolic risk factors (BMI, WC, AC and anti-oxLDL). Our results demonstrate that obesity in adolescents is associated with high levels of LDL(2) and low plasma a-TP content.

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“…[8][9][10] Many reports have described the relationship between an increase in LDL(-) levels and increased CV disease risk in patients with hypercholesterolemia and diabetes mellitus. [10][11][12] Our group also found high-LDL(-) levels in patients undergoing hemodialysis (HD), 13 suggesting that this increased levels of LDL(-) could be involved in the progress of the atherogenic process in CKD patients.…”

Section: Introductionmentioning

confidence: 88%

Reduced Plasma Zinc Levels, Lipid Peroxidation, and Inflammation Biomarkers Levels in Hemodialysis Patients: Implications to Cardiovascular Mortality

Lobo¹,

Stockler‐Pinto²,

Farage³

et al. 2013

Renal Failure

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Despite the fact that low plasma zinc (Zn) levels play important roles in the oxidative stress, the relationships between lipid peroxidation and inflammation biomarkers with low plasma Zn levels have not been investigated in chronic kidney disease (CKD) patients. The aim of this study was to evaluate the Zn plasma levels, electronegative LDL [LDL(-)] levels, and inflammation markers as predictors of cardiovascular (CV) mortality in hemodialysis (HD) patients. Forty-five HD patients (28 men, 54.2 AE 12.7 years, 62.2 AE 51.4 months on dialysis and BMI 24.3 AE 4.1 kg/ m 2 ) were studied and compared to 20 healthy individuals (9 men, 51.6 AE 15.6 years, BMI 25.2 AE 3.9 kg/m 2 ) and followed for 24 months to investigate the risks for CV mortality. LDL(-) levels were measured by ELISA, plasma Zn levels by atomic absorption spectrophotometry, C-reactive protein (CRP) level by immunoturbidimetric method, and tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1) levels by a multiplex assay kit. HD patients presented low plasma Zn levels (54.9 AE 16.1 μg/dL) and high-LDL(-) (0.18 AE 0.12 U/L) and TNF-α (5.5 AE 2.2 pg/mL) levels when compared to healthy subjects (78.8 AE 9.4μ g/dL, 0.10 AE 0.08U/L, 2.4 AE 1.1 pg/mL, respectively, p < 0.05). Zn plasma levels were negatively correlated to TNF-α (r ¼ -0.49; p ¼ 0.0001) and LDL(-) (r ¼ -0.33; p ¼ 0.008). During the 2 years, 24.4% of the patients died, all due to CV disease. Analysis by the Cox model showed that high CRP, TNF-α, IL-6 levels, and long duration of HD were significant predictors of mortality. In conclusion, reduced Zn levels were associated with lipid peroxidation and inflammation, and we confirm here in a Brazilian cohort of HD patients that inflammation markers are strong predictors of CV death.

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Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes

Cited by 46 publications

References 55 publications

The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria

The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria

Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?

Reduced Plasma Zinc Levels, Lipid Peroxidation, and Inflammation Biomarkers Levels in Hemodialysis Patients: Implications to Cardiovascular Mortality

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