Minimization of Cytogenetic Toxicity of Malathion by Vitamin C.

Hoda, Qamrul; Sinha, S. P.

doi:10.3177/jnsv.37.329

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…However, life-time feeding of ascorbic acid does not increase the life span of these two strains of flies [53]. Ascorbic acid appreciably minimized the cytogenetic toxicity of the organophosphorous pesticides Malathion and Rogor in D. melanogaster [54,55]. It was also effective in reducing the genotoxicity of potassium dichromate to the control levels in the wing spot test of Drosophila [56].…”

Section: Discussionmentioning

confidence: 99%

Paraquat-induced Oxidative Stress in Drosophila melanogaster: Effects of Melatonin, Glutathione, Serotonin, Minocycline, Lipoic Acid and Ascorbic Acid

et al. 2006

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The efficacy of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid in counteracting the toxicity of paraquat in Drosophila melanogaster was examined. Male Oregon wild strain flies were fed for 5 days with control food or food containing the test substance. They were transferred in groups of five to vials containing only filter paper soaked with 20 mM paraquat in 5% sucrose solution. Survival was determined 24 and 48 h later. All the substances assayed increased the survival of D. melanogaster. At equimolar concentrations (0.43 mM) melatonin was more effective than serotonin, lipoic acid and ascorbic acid. However, lower concentrations of glutathione (0.22 mM) and minocycline (0.05 mM) were as efficient as melatonin. The highest survival rate (38.6%) after 48 h of paraquat treatment was found with 2.15 mM of lipoic acid. No synergistic effect of melatonin with glutathione, serotonin, minocycline, lipoic acid and ascorbic acid was detected.

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Section: Discussionmentioning

confidence: 99%

Paraquat-induced Oxidative Stress in Drosophila melanogaster: Effects of Melatonin, Glutathione, Serotonin, Minocycline, Lipoic Acid and Ascorbic Acid

et al. 2006

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“…Antioxidant vitamins C and E have been shown to reduce lipid peroxidation caused by toxic substances (Appenroth et al, 1997;Gultekin et al, 2000). Although OP insecticides are genotoxic, Hoda and Sinha (1991) demonstrated that their cytogenic effect is greatly reduced by vitamin C administration.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Subchronic Chlorpyrifos Poisoning on Hematological and Serum Biochemical Changes in Mice and Protective Effect of Vitamin C

Ambali¹,

Akanbi²,

Igbokwe³

et al. 2007

J. Toxicol. Sci.

108

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-Chlorpyrifos (CPF) is one of the most widely used organophosphorous insecticides in agriculture with its attendant adverse health outcomes. This study aimed at evaluating the effect of subchronic oral CPF administration on hematological and serum biochemical indices, and the possible ameliorating effect of vitamin C on the indices in mice. Thirty mice divided into 3 groups of 10 mice each were used for this study. Mice in group I (control) were dosed with vegetable oil, while those in group II were given CPF (21.3 mg/kg~ 1/5 th LD 50 ) only. Mice in group III were pretreated with vitamin C (100 mg/kg) prior to dosing with CPF 30 min later (Vitamin C + CPF-treated group). This regime was given to each group of mice three times a week for a period of ten weeks. During the study period, mice were examined for signs of toxicity, and weight of each mouse was measured every week. At the end of the study period, blood samples were collected from the mice and analyzed for packed cell volume (PCV), total red blood cell (RBC), white blood cell (WBC) and total protein (TP). Serum obtained from the blood was analyzed for Na + , K + and Cl − , urea, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). The results showed that mice in the vitamin C + CPF-treated group exhibited milder signs of toxicity and significant increase in weight gain (p<0.01) compared to the CPF-treated group. No significant increase in weight in the CPF-treated group was observed compared to the control. There was a significant increase in PCV, RBC, Hb, TP and creatinine, but a significant decrease was obtained in WBC, ALT and AST in the CPF-treated group compared to the control. All the parameters with the exception of WBC, ALT and AST (which increased significantly), were significantly decreased in the vitamin C + CPF-treated group compared to CPF-treated group. ALP was significantly elevated in the CPF-treated group compared to both the control and vitamin C + CPF-treated group. No significant changes in urea and the measured electrolytes in all three groups, except a significant decrease in the concentration of Na + was observed in the CPF-treated group compared to the control. The study demonstrated that pretreatment of CPF-administered mice with vitamin C significantly altered some important hematological and serum biochemical parameters, revealing the protective action of the vitamin against some organ damage induced by CPF.

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“…Use of vitamin C (L-ascorbic acid) as an antimutagen has been shown to be a promising solution to circumvent the genotoxicity of pesticides in vivo [1][2][3][4][5][6]. The recommended dietary allowances (RDA) for this vitamin to prevent scurvy is 45-60 mg/day for a healthy person [7].…”

Section: Introductionmentioning

confidence: 99%

Impact of higher doses of vitamin C in modulating pesticide genotoxicity

Khan¹,

Sinha²

1994

Teratog Carcinog Mutagen

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The modulatory effect of higher doses of vitamin C (ascorbic acid) on the genotoxicity of the three pesticides (endosulfan, phosphamidon, and mancozeb) was assessed in the in vivo micronucleus test in Swiss albino mice. Concurrent administration of the vitamin in a dose (20 mg/kg bwt/day) equivalent to double the human therapeutic one, along with each of the three pesticides, was most effective as an antimutagen. The therapeutic dose (10 mg/kg bwt/day) was comparatively less so, and the quadruple (40 mg/kg bwt/day) of it did not show any further amelioration.

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Minimization of Cytogenetic Toxicity of Malathion by Vitamin C.

Cited by 9 publications

References 13 publications

Paraquat-induced Oxidative Stress in Drosophila melanogaster: Effects of Melatonin, Glutathione, Serotonin, Minocycline, Lipoic Acid and Ascorbic Acid

Paraquat-induced Oxidative Stress in Drosophila melanogaster: Effects of Melatonin, Glutathione, Serotonin, Minocycline, Lipoic Acid and Ascorbic Acid

Evaluation of Subchronic Chlorpyrifos Poisoning on Hematological and Serum Biochemical Changes in Mice and Protective Effect of Vitamin C

Impact of higher doses of vitamin C in modulating pesticide genotoxicity

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