Miniplasmid Derived from Listeria monocytogenes Multiresistance Plasmid pWDB100 upon Conjugal Transfer into Staphylococcus epidermidis Carries Chloramphenicol Resistance Gene Identical with Staphylococcal Gene

Hadorn, K.; Kayser, Fritz H.; Hächler, Herbert

doi:10.1016/s0723-2020(11)80067-6

Cited by 6 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…represent the origin of multiple antibiotic resistance in L. monocytogenes (2,7,21,35). In a more recent study (22), plasmid pWDB100/m (2,679 bp) was detected in S. epidermidis transconjugants that had acquired the multiresistance plasmid pWDB100. Plasmid pWDB100/m conferred resistance to chloramphenicol and cor- responded to an excised derivative of pWDB100 (Fig.…”

Section: Acquired Multiple Resistance In L Monocytogenes Mediated Bymentioning

confidence: 97%

“…1). The gene encoding a chloramphenicol acetyltransferase belonged to the family of cat determinants of the pC223 family of plasmids that replicate using a single-stranded intermediate (22).…”

Section: Acquired Multiple Resistance In L Monocytogenes Mediated Bymentioning

confidence: 99%

“…No cases of resistance to penicillins, gentamicin, or vancomycin have been reported for strains of Listeria spp. originating from humans, food, or the environment (9,14,22,44).…”

Section: Resistance To Other Antibiotics Inmentioning

confidence: 99%

See 2 more Smart Citations

Antibiotic Resistance in Listeria spp

Charpentier

Courvalin

1999

Antimicrob Agents Chemother

308

170

View full text Add to dashboard Cite

Section: Acquired Multiple Resistance In L Monocytogenes Mediated Bymentioning

confidence: 97%

Section: Acquired Multiple Resistance In L Monocytogenes Mediated Bymentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic Resistance in Listeria spp

Charpentier

Courvalin

1999

Antimicrob Agents Chemother

308

170

View full text Add to dashboard Cite

“…The cat genes commonly found in staphylococci [44–55], streptococci [56–60] and enterococci [61,62], but also in B. subtilis [63], Listeria monocytogenes [64], Lactobacillus reuteri [65] and Lactococcus lactis [66,67] represent the three groups of cat genes A‐7–A‐9. The prototype plasmids from which sequences of the respective cat genes had first been deposited in the databases are pC221 [45,46], pSCS7 [50], and pC194 [44].…”

Section: Bacterial Resistance To Chloramphenicol and Florfenicolmentioning

confidence: 99%

Molecular basis of bacterial resistance to chloramphenicol and florfenicol

et al. 2004

View full text Add to dashboard Cite

Chloramphenicol (Cm) and its fluorinated derivative florfenicol (Ff) represent highly potent inhibitors of bacterial protein biosynthesis. As a consequence of the use of Cm in human and veterinary medicine, bacterial pathogens of various species and genera have developed and/or acquired Cm resistance. Ff is solely used in veterinary medicine and has been introduced into clinical use in the mid-1990s. Of the Cm resistance genes known to date, only a small number also mediates resistance to Ff. In this review, we present an overview of the different mechanisms responsible for resistance to Cm and Ff with particular focus on the two different types of chloramphenicol acetyltransferases (CATs), specific exporters and multidrug transporters. Phylogenetic trees of the different CAT proteins and exporter proteins were constructed on the basis of a multisequence alignment. Moreover, information is provided on the mobile genetic elements carrying Cm or Cm/Ff resistance genes to provide a basis for the understanding of the distribution and the spread of Cm resistance--even in the absence of a selective pressure imposed by the use of Cm or Ff.

show abstract

“…As the insert does not encode the associated Mob protein, this site cannot be used for plasmid mobilization unless a cognate Mob protein is provided in trans (Oskam et al, 1991). Third, the overall insert is Ϸ85% homologous to a RC replicon present in pWDB100, a 39 kb-long, conjugative plasmid isolated from Listeria monocytogenes (Hadorn et al, 1994). Interestingly, pWDB100 is highly related to pIP501 and the RC replicon is located at the same position as in pIP501 (Hadorn et al, 1993).…”

Section: Figmentioning

confidence: 99%

Inhibition of a naturally occurring rolling‐circle replicon in derivatives of the theta‐replicating plasmid pIP501

Pujol

Chédin

Ehrlich

et al. 1998

Molecular Microbiology

View full text Add to dashboard Cite

SummaryThe mechanisms ensuring regulation of DNA replication in genomes containing multiple replicons are poorly understood. In this report, we addressed this question by analysing in Bacillus subtilis the replication of a derivative of the promiscuous plasmid pIP501 that carries a rolling-circle and a theta replicon. Genetic analyses revealed that the rolling-circle replicon is strongly inhibited in the derivative and that inhibition requires three elements involved in theta replication: the replication origin, the initiator RepR protein and strong transcription of the repR gene. Inhibition is, however, independent of DNA synthesis at the theta origin. We conclude that rolling-circle inhibition is caused by an inhibitor y signal encoded by the theta replicon and propose that the signal is composed, at least, of the RepR protein bound to its cognate origin.

show abstract

Miniplasmid Derived from Listeria monocytogenes Multiresistance Plasmid pWDB100 upon Conjugal Transfer into Staphylococcus epidermidis Carries Chloramphenicol Resistance Gene Identical with Staphylococcal Gene

Cited by 6 publications

References 45 publications

Antibiotic Resistance in Listeria spp

Antibiotic Resistance in Listeria spp

Molecular basis of bacterial resistance to chloramphenicol and florfenicol

Inhibition of a naturally occurring rolling‐circle replicon in derivatives of the theta‐replicating plasmid pIP501

Contact Info

Product

Resources

About