“…The ad hoc SYNHEAT superstructure for the optimization of the proposed CH2P plant has the following characteristics [30,24]: (i) constant h values for each stream, along the different periods (calculated from the steady state simulations); (ii) the minimum temperature (ΔT min ) is given as an input, thus, not considered for optimization; (iii) each HEX is assigned to the same pair of hot and cold streams at all the periods; (iv) countercurrent HEX configuration; (v) a fix number of stages established by the user (below the maximum number of either the hot and cold streams), as defined in the SYNHEAT superstructure [24]; (vi) for each stage, streams are split to cover all hot and cold streams matches; (vii) the outlet temperatures of each stage, for each stream, are treated as variables; (viii) in order to simplify the model formulation, utilities are placed at the outlet of the superstructure and streams are mixed isothermally; (ix) the approach from [31] is used to model condensers, evaporators and isothermal reactors; (x) consideration of one hot and one cold utility; (xi) the hot utility load is treated as a decision variable of the master (upper) level optimization, and therefore, it is treated as a process stream; (xii) the cold utility is considered a cold end, reducing the size of the combinatorial (superstructure) problem; (xiii) the HEN design can restrict stream splitting, can forbid matches and restrict/oblige other matches (e.g., avoid the contact of a combustible stream with an O 2 -rich stream); parallel and in-series configurations are allowed; (xiv) the dynamics when changing flow rates or temperatures between periods, e.g., residence times and thermal inertia, are neglected; (xv) the SYNHEAT approach does not deal with streams' temperatures change, but these are modified by the MOO algorithm.…”