Minocycline in pyoderma gangrenosum

Mutalik, Sharad; Gharpuray, Mohan B

doi:10.3109/09546639209088713

Cited by 1 publication

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“…It is of great interest that a complete resolution of the skin lesions and a dramatic improvement in the granulomatous uveitis were observed in our patient after the introduction of minocycline therapy. Cutaneous healing in PG has however been reported previously with such treatment, 13,14 but more surprising was the improvement in uveitis in our patient within a month of the introduction of minocycline, whereas the well-recognized topical treatment of 1% atropine solution and dexamethasone had been ineffective over 4 months. Such efficacy for minocycline in both PG and CS might perhaps be explained by its anti-inflammatory properties, 15 and indeed in CS, histological examination shows a nonspecific polymorphic inflammatory infiltrate or a necrotizing vasculitis, 2,9 whereas in PG the cutaneous infiltrate is composed mainly of polymorphonuclear neutrophils.…”

Section: Discussionsupporting

confidence: 43%

Pyoderma gangrenosum complicating Cogan's syndrome

Boulinguez

Bernard

Bédane

et al. 1998

Clinical and Experimental Dermatology

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Cogan's syndrome is a rare clinical entity defined by the association of a nonsyphilitic interstitial keratitis and vestibuloauditory dysfunction, typically Menière's disease-like; the condition has been reported in association with a variety of cutaneous diseases. We now report a case of pyoderma gangrenosum complicating Cogan's syndrome in a 57-year-old woman, which then healed dramatically, as more interestingly did the associated uveitis with minocycline therapy.

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Section: Discussionsupporting

confidence: 43%