Minor alkaloids of Tylophora asthmatica

Govindachari, T. R.; Viswanathan, N.; Radhakrishnan, J.; Pai, B. R.; Natarajan, S.; Subramaniam, P.

doi:10.1016/0040-4020(73)80034-1

Cited by 47 publications

(33 citation statements)

References 17 publications

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“…for C 23 H 22 NO 3 + : 360.1599) and a positive silver chloride deposition reaction. The strong absorption bands in the UV spectrum at 340 (3.46) and 286 (4.56) nm were similar to those of dehydrotylophorine, which indicated that 1 was an aromatic alkaloid [9]. In the 1 H-NMR spectrum, three methoxy groups resonated at d Fig.…”

Section: Resultsmentioning

confidence: 84%

“…Therefore, the structure of compound 1 could be elucidated as 3,6,7-trimethoxy-9(10),13a(14)-dehydrophenanthroindolizidinium chloride. Govindachari inferred the presence of this compound during his isolation of the minor tertiary alkaloids of Tylophora asthmatica, but it could not be obtained as such [9]. Original Paper 443 ence a 1,2,4-trisubstituted phenyl ring (ring A).…”

Section: Resultsmentioning

confidence: 97%

“…As hydrochloric acid was used during the extraction, 1 was probably an artificial compound [9]. Although 3 and 4 were N-oxides of 7 and 6, respectively, they were not possible artifacts, because we had tried to get 3 and 4 through 7 and 6 but failed even when the latter two compounds were illuminated or heated in chloroform.…”

Section: Discussionmentioning

confidence: 98%

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Cytotoxic Alkaloids from the Roots ofTylophora atrofolliculata

Huang

Gao²,

Fan³

et al. 2004

Planta med

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Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxic activity in vitro on HCT-8 cell (with IC50 values in the range 0.083 to 18.99 microM) and KB cell (in the range 3.56 to 18.22 microM) lines.

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Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 97%

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Cytotoxic Alkaloids from the Roots ofTylophora atrofolliculata

Huang

Gao²,

Fan³

et al. 2004

Planta med

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“…[1] The plant has been reported to contain 0.2-0.46% alkaloids viz. Tylophorine, tylophorinine, [2,3] tylophorinidine, (+)-septicine, isotylocrebrine, [4] tylophorinicine, sterols, flavonoids, [5] wax, resins and tannins.…”

Section: Animalsmentioning

confidence: 99%

“…Results of histopathological studies on the liver of CCI 4 intoxicated ratsControlControl group showed normal hepatocytes in cord pattern with portal triads and central vein CCl4 treatedToxic group showed diffuse fatty changes across hepatic lobule and marked congestion with lymphocytic infiltrate. CCl 4 + silymarin standard group showed normal appearance of liver parenchyma in the periportal of mild zonal areas CCl 4 + extract (200 mg/kg) Extract treated livers showed mild fatty changes restricted to centribular zone with sparing of periportal hepatocytes CCl 4 + extract (300 mg/kg) Extract treated livers showed mild fatty changes Source of Support: Nil, Conflict of Interest: None declared.…”

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confidence: 98%

Hepatoprotective activity of the methanolic extract ofTylophora indica(Burm. f.) Merill. leaves

et al. 2009

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Plant MaterialTylophora indica leaves were collected from herbal garden, Jamia Hamdard and authenticated by the taxonomist of Department of Botany, Faculty of Science, Hamdard University. The voucher specimen was deposited in the herbarium of university for future reference.The methanolic extract of Tylophora indica leaves was screened for hepatoprotective activity in carbon tetrachloride induced hepatotoxicity in albino rats. The degree of protection was measured by estimating biochemical parameters like Serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, total protein and level of serum bilirubin (both total and direct). Hepatoprotective activity of methanolic extract at a dose of 200 mg/kg and 300 mg/kg body weight, i.p., was compared with Silymarin (25 mg/kg, i.p.) treated animals. Tylophora indica leaves (200 and 300 mg/kg) exhibited significant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. Furthermore, histopathological studies were also done to support the study.

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