Minor salivary gland involvement in Sjögren's syndrome

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren׳s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study

“…For histological evaluation, H&E-stained sections were assessed as follows: (i) the histological pattern (normal, NSCS, or FLS) [5]; (ii) the Chisholm and Mason grading system (grades 0-4) [6]; (iii) the Tarpley score (scores 0-4) [7]; (iv) a grading for the severity of inflammatory infiltrate (grades 1-5) [9,10]; and (v) the focus score, assessing the number of foci/4 mm 2 (a focus is defined as an aggregate including at least 50 mononuclear cells) [8]. A biopsy was considered GC positive (GC þ ) if displaying at least one focus with lymphoid-like organization within normal MSG tissue.…”

“…In addition to FLS, different morphologic patterns of chronic inflammation commonly occur in MSG biopsy specimens: non-specific chronic sialadenitis (NSCS) and sclerosing chronic sialadenitis (SCS) [5]. Different histological scores have been employed to describe glandular involvement during pSS [6][7][8][9][10], and as far as MSGs histology is concerned, its diagnostic role is widely accepted and currently considered the "gold standard." Indeed, MSG biopsy is considered 1 of the 4 objective criteria of American-European Consensus Group's classification and 1 of the 3 objective criteria of American College of Rheumatology's classification for pSS [11,12].…”

Labial salivary gland biopsy in sjögren's syndrome

“…In another study, when LSG hiopsies from 86 patients were graded by qualitative criteria, more and larger aggregates of lymphocytes and plasma cells were observed in patients with SS than in those with both SS and RA (36). In a series of 11 1 LSG biopsies, focal sialadenitis was observed in 81% of specimens from patients with SS, in 36% with CTD, and in none with other diseases; however, their diagnostic criteria for SS were not reported (37).…”

The incidence of sjögren's sicca complex in a population of patients with keratoconjunctivitis sicca

“…The biopsies were assessed for glandular involvement in patients in this series by techniques described previously (1 I). Each biopsy was evaluated and graded (0-IV) for Sjogren's oral component by the classification established by Greenspan et al (12) and Tarpley et al (13). No attempt was made to determine what grade level of biopsy was significant, but rather, the results were placed in the perspective of other findings as described later.…”