The incidence of sjögren's sicca complex in a population of patients with keratoconjunctivitis sicca

Forstot, Joseph Z.; Forstot, S. Lance; Greer, Robert O.; Tan, Eng M.

doi:10.1002/art.1780250207

Cited by 28 publications

(6 citation statements)

References 13 publications

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“…Clearly, patients can have KCS and another connective tissue disease but not have FLS, and still receive a diagnosis of secondary SS (as did 14 of our patients). Patients can also have KCS only, separate from SS (as did 75 of our patients, and as has been noted by other investigators [7]). Finally, the presence of serum autoantibodies is common to many diseases.…”

Section: Replysupporting

confidence: 90%

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Daniels¹,

Whitcher²

1995

Arthritis & Rheumatism

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Section: Replysupporting

confidence: 90%

Reply

Daniels¹,

Whitcher²

1995

Arthritis & Rheumatism

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“…Forstot et al made a study of 45 patients with keratoconjunctivitis sicca with respect to oral and serological findings and observed SS in eight (17%) 2. In a long term follow up study of 106 SS patients a subgroup of patients with isolated keratoconjunctivitis sicca was also described 3.…”

mentioning

confidence: 99%

Clinical follow up study of 87 patients with sicca symptoms (dryness of eyes or mouth, or both)

Pertovaara

Korpela

Uusitalo

et al. 1999

Annals of the Rheumatic Diseases

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Sjögren's syndrome (SS) is a chronic autoimmune exocrinopathy characterised by dryness of eyes (keratoconjunctivitis sicca) and mouth (xerostomia) as well as recurrent parotid or submandibular gland swellings. The clinical course of SS has been regarded as chronic, mild and stable. However, apart from the eVects on the lacrimal and salivary glands, various extraglandular manifestations may develop. Also, an increased risk of lymphoproliferative diseases, especially of non-Hodgkin's lymphoma, has been related to SS. 1 Scant attention has been paid to the prognosis and progression of mild, smouldering diseases and sicca symptoms. Forstot et al made a study of 45 patients with keratoconjunctivitis sicca with respect to oral and serological findings and observed SS in eight (17%).2 In a long term follow up study of 106 SS patients a subgroup of patients with isolated keratoconjunctivitis sicca was also described. 3None of the patients with isolated keratoconjunctivitis sicca developed lymphoproliferative disease.Our study was specifically designed to evaluate the prognosis of SS in the mildest forms of its clinical spectrum and to obtain further information on the natural history of primary SS (pSS). The main purpose was to identify the most useful clinical and immunological indicators of the subsequent development of SS in patients with early onset sicca symptoms. Methods SELECTION OF SUBJECTS WITH SICCA SYMPTOMS FOR RE-EVALUATIONThe charts of 259 subjects with sicca symptoms initially examined in the Department of Internal Medicine, Section of Rheumatology, in Tampere University Hospital during the years 1977 to 1986 were reviewed by one of the authors (MP). Californian criteria 4 with the modifications that salivary flow rate measurements were not performed and the histological findings were graded according to the Chisholm-Mason scale 5 grades 3 and 4 regarded as diagnostic, were applied in the diagnosis of SS. One hundred and nine patients with sicca symptoms fulfilling two or less of the criteria were included in the study. Of these, 14 subjects had died; the causes of death being cardiovascular in seven, malignancy in five, hepatic cirrhosis in one, and accident in one patient. The remaining 95 subjects were invited for re-evaluation. A total of 87 subjects (92% of those invited) attended the study. They comprised 72 women and 15 men with a median age of 60 years (range, 28-80 ) and a median follow up time of 11 years (range, 8-17).

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“…Forstot et a1 (22) have noted that the prevalence of anti-SS-B in a dry eyes clinic was lower than that in previous reports from rheumatic disease units ( I ,3). It is of interest that in their study 6 of the 7 patients with anti-SS-B had systemic features.…”

Section: Discussionmentioning

confidence: 71%

Quantitation and detection of isotypes of ANTI‐SS‐B antibodies by elisa and farr assays using affinity purified antigens

Venables

Charles

Buchanan

et al. 1983

Arthritis & Rheumatism

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Affinity purified SS‐B was characterized as a protein with immunoreactive polypeptides of 40K and 29K. A modified Farr assay and an enzyme linked immunosorbent assay (ELISA) were 100‐ to 1,000‐fold more sensitive than immunodiffusion and showed an association with the systemic manifestations of primary sicca syndrome and Sjögren's syndrome with systemic lupus erythematosus. The ELISA was sufficiently sensitive to detect class specific antibodies in saliva and lymphocyte culture supernatants.

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The incidence of sjögren's sicca complex in a population of patients with keratoconjunctivitis sicca

Cited by 28 publications

References 13 publications

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Clinical follow up study of 87 patients with sicca symptoms (dryness of eyes or mouth, or both)

Quantitation and detection of isotypes of ANTI‐SS‐B antibodies by elisa and farr assays using affinity purified antigens

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