Minor Steroidal Sapogenins from Fenugreek Seeds, Trigonella foenum-graecum

Gupta, Ramji; Jain, D. C.; Thakur, Raghunath S.

doi:10.1021/np50048a043

Cited by 19 publications

(20 citation statements)

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“…Additionally, dietary fiber may significantly contribute to fenugreek's activity in lowering blood glucose and cholesterol (Gupta, Jain, & Thakur, 1986; Valette, Sauvaire, Baccou, & Ribes, 1984). Another main component of fenugreek which has been reported to have modulating effect on dyslipidemia is saponin (Fuller & Stephens, 2015; Uemura et al, 2011; Verma et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Another main component of fenugreek which has been reported to have modulating effect on dyslipidemia is saponin (Fuller & Stephens, 2015; Uemura et al, 2011; Verma et al, 2016). Indeed many studies showed that the hypocholesterolemic effect of fenugreek was due to the saponin‐rich subfraction (Gupta et al, 1986; Sauvaire, Ribes, Baccou, & Loubatieères‐Mariani, 1991). A study by Chen et al showed that saponins can effectively accelerate cholesterol metabolism and process of reverse cholesterol transport (RCT), meanwhile prohibit cholesterol synthesis and therefore effectively reduce TC level (Chen et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Heshmat-Ghahdarijani

Mashayekhiasl

Amerizadeh

et al. 2020

Phytotherapy Research

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Various studies have shown that Trigonella foenum‐graecum (fenugreek) supplementation has lipid‐lowering activity. This meta‐analysis was performed to evaluate the effect of fenugreek supplementation on human serum lipid profile. Data sources were PubMed, EMBASE, Scopus, and Coherence library which were searched systematically from January 2000 up to December 2019. Inclusion criteria were randomized clinical trial (RCT) study design, at least one of lipid profile components (triglyceride [TG], total cholesterol [TC], low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol) levels measured before fenugreek use and one of the lipid components level reported as result. The pooled weighted mean difference (MD) and its 95% confidence interval (CI) were calculated and pooled using a random‐effect model. Only articles published in English were considered. Fifteen RCTs involving 281 cases consumed fenugreek and 255 control cases in controlled group (11 articles) and 136 cases in uncontrolled group (4 articles) were analyzed in our study. Pooled data of indicated a significant impact of fenugreek supplementation on lowering TC (−1.13 [−1.88, −0.37]; p = .003), low‐density lipoprotein (LDL) (−1.26 [−2.09, −0.43]; p = .003), and TG (−1.07 [−1.82, −0.33]; p = 0.005) and increasing the high‐density lipoprotein (HDL) level (0.70 [0.07, 1.34]; p = .03) compared with the control group. There were no significant differences in TC, TG, and LDL between pre‐ and post‐fenugreek studies in the noncontrolled studies however, the result of combination of four studies without control group showed a significant increase in mean HDL (0.81 [0.33,1.29]; p‐value = .001). The results of subgroup analysis showed that the fenugreek reduced the TG and LDL and increases HDL levels in diabetic subjects more effectively. Fenugreek supplementation significantly improved lipid profile (LDL, TG, TC, and HDL). It could be considered as an effective lipid‐lowering medicinal plant. Further high‐quality studies are needed to firmly establish the clinical efficacy of the plant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Heshmat-Ghahdarijani

Mashayekhiasl

Amerizadeh

et al. 2020

Phytotherapy Research

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“…Dietary fibers and saponins that are present are specifically known to enhance hypoglycemic activity. Additionally, dietary fiber may significantly contribute to fenugreek's activity in lowering blood glucose and cholesterol ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes

Verma

Usman

Patel

et al. 2016

Food & Nutrition Research

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BackgroundTrigonella foenum-graecum (fenugreek) seeds are known to exhibit potent antioxidant, hypoglycemic, and nephroprotective activities, as well as serve as excellent membrane stabilizers especially because of their content of novel furostanolic saponins. Our previous studies exhibited the broad spectrum safety and efficacy of Fenfuro, a novel T. foenum-graecum seed extract enriched in furostanolic saponins, in type 2 diabetes (T2D) in rats.DesignThis multicenter, randomized, placebo-controlled, double-blind, add-on clinical study evaluated over a period of 90 consecutive days the efficacy of Fenfuro (daily dosage: 500 mg bid) in 154 subjects (male: 108; female: 46; age: 25–60 years) with T2D.MethodsThis study examined the body weight, blood pressure, and pulse rate, as well as the efficacy of Fenfuro on fasting and post-prandial plasma sugar (mg/dL), glycosylated hemoglobin (HbA1c), and fasting and post-prandial C-peptide levels.ResultsFenfuro caused significant reduction in both fasting plasma and post-prandial blood sugar levels. Approximately 83% of the subjects reported decreases in fasting plasma sugar levels in the Fenfuro-treated group as compared to 62% in the placebo group, while 89% of the subjects demonstrated reduction in post-prandial plasma sugar levels in the Fenfuro-treated group as compared to 72% in the placebo group. HbA1c levels were reduced in both placebo and treatment groups. The decrease in HbA1c levels was significant in both groups as compared to respective baseline values. A significant increase in fasting and post-prandial C-peptide levels compared to the respective baseline values was observed, while no significant changes in fasting and post-prandial C-peptide levels were observed between the two groups. No significant adverse effects were observed by blood chemistry analyses. Furthermore, 48.8% of the subjects reported reduced dosage of anti-diabetic therapy in the Fenfuro-treated group, whereas 18.05% reported reduced dosage of anti-diabetic therapy in the placebo group.ConclusionIn summary, Fenfuro proved safe and efficacious in ameliorating the symptoms of T2D in humans.

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“…3b) (Gupta et al 1986) that is Skaltsa 2002). Isoleucine, being an underlying branchedchain amino acid (BCAA), found to be the key precursor for synthesis of 4-hydroxyisoleucine and serves as an efficient factor in regulating the insulin secretion in animals (Broca et al 2000) and making it potentially useful in the control of diabetes (Acharya et al 2008).…”

Section: Seed Chemical Compoundsmentioning

confidence: 95%

Fenugreek (Trigonella foenum-graecum L.) seed: a review of physiological and biochemical properties and their genetic improvement

et al. 2014

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Discovering the complexity of seed structure and function along with a number of vital processes such as seed growth and development, germination are important factors in unlocking the secrets of consistent crop yield.Fenugreek (Trigonella foenum-graecum L.), a multi-purpose annual, dryland-adapted, forage, legume crop is cultivated in different parts of the world with great potential for introduction under suitable agro-climatic zones in subSaharan Africa and Latin America. Fenugreek seed is used extensively for its medicinal, pharmaceutical and nutraceutical properties. It is effective in the treatment of diabetes, hyperglycaemia (thyroxine-induced type) and hypercholesterolemia. This review discusses seed physiological processes and several important biochemical seed constituent, e.g., steroidal sapogenins (diosgenin), polysaccharide fiber (galactomannan), amino acid (4-hydroxyisoleucine), etc, with important medicinal and pharmacological characteristics impacting human and animal health. However, there are noticeable differences in the quality of several phytochemicals found in fenugreek seed possibly due to variations in plant genotypes and agroclimatic conditions under which the crop is grown. Hence, it is important to note that for consistent seed yield and quality of fenugreek cultivars there is an urgent need for Communicated by A.

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Minor Steroidal Sapogenins from Fenugreek Seeds, Trigonella foenum-graecum

Cited by 19 publications

References 1 publication

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes

Fenugreek (Trigonella foenum-graecum L.) seed: a review of physiological and biochemical properties and their genetic improvement

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