MIP-1a and MIP-1b in serum as potential markers of the severe course COVID-19

Гришаева, А. А.; Понежева, Ж.Б.; Чанышев, М. Д.; Плоскирева, А. А.; Usenko, D.S.; Tsvetkova, Natalia; Омарова, Х С; Pshenichnaya, N.

doi:10.1016/j.ijid.2021.12.105

Cited by 5 publications

(3 citation statements)

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“…By its structure, macrophage-derived chemokine is not homologous to most chemokines. It is most similar to thymus-and activation-regulated chemokine (TARC), with a 37% identity [17], which explains its active participation in thymocyte migration. Its role is dual: it is important for adequate lymphocyte development and it aids T regular lymphocytes in their contacts with APCs.…”

Section: Macrophage-derived Chemokine (Mdc/ccl22) and Its Functions 2...mentioning

confidence: 99%

“…TARC/CCL17 is one of the ligands for CCR4 receptor (also known as CD194), along with CCL2 (MCP-1), CCL4 (MIP-1), and CCL5 (RANTES). All CCR4 ligand chemokines are shown to be involved in COVID-19 associated immunity; however, it is more common for all of them, except RANTES/CCL5 and MDC/CCL22, to show elevated concentrations in blood plasma [17][18][19].…”

Section: Macrophage-derived Chemokine (Mdc/ccl22) and Its Functions 2...mentioning

confidence: 99%

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Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19

Korobova,

Arsentieva,

Totolian

2023

IJMS

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Macrophage-derived chemokine (MDC/CCL22) is a chemokine of the C-C subfamily. It is involved in T-cellular maturation and migration. Our previous research shows that plasma CCL22/MDC tends to show a statistically significant depletion of concentrations in acute patients and convalescents when compared to healthy donors. In the current work, we investigate existing views on MDC/CCL22 dynamics in association with various pathologies, including respiratory diseases and, specifically, COVID-19. Additionally, we present our explanations for the observed decrease in MDC/CCL22 concentrations in COVID-19. The first hypothesis we provide implies that viral products bind to MDC/CCL22 and block its activity. Another explanation for this phenomenon is based on dendritic cells population and the inhibition of their function.

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Section: Macrophage-derived Chemokine (Mdc/ccl22) and Its Functions 2...mentioning

confidence: 99%

Section: Macrophage-derived Chemokine (Mdc/ccl22) and Its Functions 2...mentioning

confidence: 99%

Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19

Korobova,

Arsentieva,

Totolian

2023

IJMS

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“…The lower levels of the pro-inflammatory factors IL-1β, RANTES and MIP-1β, and of IL-9, a cytokine with direct and indirect effects on multiple cell types that affect the development of immunity and inflammation, may be indicative in our study cohort of a controlled inflammatory process, in which the IL-1ra exerts an effective action. Indeed, a higher production of IL-1β, RANTES, MIP-1β and IL-9 have been found in the severe disease ( 18 , 59 , 62 ). The differences, in terms of cytokine amount, observed between swab positive and negative subjects in our cohort are highly significant (at least p=0.007) for certain immune factors (IFN-α, IL-1ra, IP-10, IL-9 and MIP-1β).…”

Section: Discussionmentioning

confidence: 97%

Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave

et al. 2022

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ObjectiveTo better define the immunopathogenesis of COVID-19, the present study aims to characterize the early immune responses to SARS-CoV-2 infection in household contacts of COVID-19 cases. In particular, innate, T- and B-cell specific responses were evaluated over time.MethodsHousehold contacts of COVID-19 cases screened for SARS−CoV−2 infection by nasopharyngeal swab for surveillance purposes were enrolled (T0, n=42). Of these, 28 subjects returned for a follow-up test (T1). The innate response was assessed by detecting a panel of soluble factors by multiplex-technology in plasma samples. Cell-mediated response was evaluated by measuring interferon (IFN)-γ levels by ELISA in plasma harvested from whole-blood stimulated with SARS−CoV−2 peptide pools, including spike (S), nucleocapsid (N) and membrane (M) proteins. The serological response was assessed by quantifying anti-Receptor-Binding-Domain (RBD), anti-Nucleocapsid (N), whole virus indirect immunofluorescence, and neutralizing antibodies.ResultsAt T0, higher levels of plasmatic IFN-α, IL-1ra, MCP-1 and IP-10, and lower levels of IL-1β, IL-9, MIP-1β and RANTES were observed in subjects with positive swab compared to individuals with a negative one (p<0.05). Plasmatic IFN-α was the only cytokine detectable in subjects with positive SARS-CoV-2 swabs with high accuracy for swab score positivity (0.93, p<0.0001). Among subjects with positive swabs, significant negative correlations were found among the RT-PCR cycle threshold values reported for genes S and N and IFN-α or IP-10 levels. At T0, the IFN-γ T-cell specific response was detected in 50% (5/10) of subjects with positive swab, while anti-RBD/anti-N antibodies showed a positivity rate of 10% (1/10). At T1, the IFN-γ T-cell specific response was detected in most of the confirmed-infection subjects (77.8%, 7/9), whereas the serological response was still observed in a minority of them (44.4%, 4/9). Overall, the swab test showed a moderate concordance with the T-cell response (78.6%, k=0.467), and a scarce concordance with the serological one (72.9%, k=0.194).ConclusionsPlasmatic IFN-α and the IFN-γ T-cell specific response appear early even in the absence of seroconversion, and show a greater positivity rate than the serological response in household contacts with positive swab.

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Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors

Zhang,

Yuan,

et al. 2024

Eur Arch Psychiatry Clin Neurosci

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MIP-1a and MIP-1b in serum as potential markers of the severe course COVID-19

Cited by 5 publications

References 0 publications

Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19

Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19

Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave

Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors

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