miR-12135 ameliorates liver fibrosis accompanied with the downregulation of integrin subunit alpha 11

Kumazoe, Motofumi; Miyamoto, Emi; Oka, Chihiro; Kondo, Miyuki; Yoshitomi, Ren; Onda, Hiroaki; Shimada, Yu; Fujimura, Yoshinori; Tachibana, Hirofumi

doi:10.1016/j.isci.2023.108730

iScience

2024

DOI: 10.1016/j.isci.2023.108730

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miR-12135 ameliorates liver fibrosis accompanied with the downregulation of integrin subunit alpha 11

Motofumi Kumazoe,

Emi Miyamoto,

Chihiro Oka

et al.

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2024

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Cited by 2 publications

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Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism

Kumazoe,

Fujimura,

Shimada

et al. 2024

Bioscience, Biotechnology, and Biochemistry

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Melanoma, a cancer arising from melanocytes, requires a novel treatment strategy because of the ineffectiveness of conventional therapies in certain patients. Fustin is a flavanonol found in young fustic (Cotinus coggygria). However, little is known about its antimelanoma effects. Our study demonstrates that fustin suppresses the growth of B16 melanoma cells. Phalloidin staining of cytoskeletal actin revealed that fustin induced a conformational change in the actin structure of melanoma cells, accompanied by suppressed phosphorylation of myosin regulatory light chain 2 (MLC2), a regulator of actin structure. Furthermore, the protein kinase A (cAMP-dependent protein kinase) inhibitor H89 completely attenuated fustin-induced downregulation of phosphorylated myosin phosphatase targeting subunit 1 (MYPT1), which is involved in dephosphorylation of MLC2. In a mouse model, administration of fustin suppressed tumor growth in B16 melanoma cells without adverse effects. In conclusion, our findings suggest that fustin effectively suppresses melanoma cell growth both in vitro and in vivo.

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Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism

Kumazoe,

Fujimura,

Shimada

et al. 2024

Bioscience, Biotechnology, and Biochemistry

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MicroRNA mediates the effects of food factors

Kumazoe,

Tachibana

2024

Bioscience, Biotechnology, and Biochemistry

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Food factors elicit physiological effects by interfering with the central dogma system, including DNA methylation, replication, transcription, and translation. MicroRNAs (miRNAs) are non-coding short RNAs that are approximately 20 nucleotides long and play a crucial role in the regulation of mRNA levels and translation processes. Importantly, miRNAs can be delivered to different locations in nanovesicles. However, little is known about their roles as mediators of the effects of food factors. This review introduces recent findings on the role of miRNAs in the beneficial effects of food factors, including green tea polyphenols and soybean isoflavones, and discusses the importance of miRNAs as mediators of the beneficial effects of food.

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miR-12135 ameliorates liver fibrosis accompanied with the downregulation of integrin subunit alpha 11

Cited by 2 publications

References 47 publications

Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism

Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism

MicroRNA mediates the effects of food factors

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