miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma

Sun, Zhanwei; Zhang, Wenqi; Li, Qian

doi:10.1186/s13578-017-0178-y

Cited by 25 publications

(23 citation statements)

References 41 publications

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“…Other evidences also favored that imatinib resistance was associated with overexpression of the MDR1 gene in tumor cells [143,144]. Consistently, miR-125a/HK2 axis was found to regulate the energy metabolism of hepatocellular carcinoma or squamous cell carcinoma [146,147]. Consistently, miR-125a/HK2 axis was found to regulate the energy metabolism of hepatocellular carcinoma or squamous cell carcinoma [146,147].…”

Section: Osteosarcoma and Myeloid Leukemiamentioning

confidence: 70%

“…In addition, UCA1 also conferred the resistance of adriamycin, a chemotherapy drug used for the treatment of AML, by sponging the miR-125a targeting HK2 to promote glycolysis [145]. Consistently, miR-125a/HK2 axis was found to regulate the energy metabolism of hepatocellular carcinoma or squamous cell carcinoma [146,147].…”

Section: Osteosarcoma and Myeloid Leukemiamentioning

confidence: 92%

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Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Xuan

Zhang

et al. 2019

FEBS Letters

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Long non-coding RNAs (lncRNAs) are a major subset of highly conserved non-coding RNAs (ncRNAs) that consist of at least 200 nucleotides and have limited protein-coding potential. Cumulative data have shown that lncRNAs are deregulated in many types of cancer and may control pathophysiological processes of cancer at various levels, including transcription, post-transcription and translation. Recently, lncRNAs have been demonstrated to interact with microRNAs (miRNAs), another major subset of ncRNAs, which regulate physiological and pathological processes by inhibiting target mRNA translation or promoting mRNA degradation. The lncRNA urothelial carcinomaassociated 1 (UCA1) has recently gained much attention as it is overexpressed in many types of cancer and is involved in carcinogenesis. Here, we review the crosstalk between UCA1 and miRNAs during the pathogenesis of cancer, with a focus on cancer-cell proliferation, invasion, drug resistance, and metabolism.

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Section: Osteosarcoma and Myeloid Leukemiamentioning

confidence: 70%

Section: Osteosarcoma and Myeloid Leukemiamentioning

confidence: 92%

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Xuan

Zhang

et al. 2019

FEBS Letters

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“…As a potential related miRNA of PIK3CB, miR-206 was reported as a regulatory miRNA on cell proliferation and apoptosis [ 50 , 51 ], and was identified with PIK3CB showing sensitive to initial injury intensity induced by freeze damage [ 52 ]. Another potential related miRNA of PIK3CB, miR-125a, was reported as important regulation miRNA on metabolism [ 53 ] and cell development [ 54 ]. However, the targeting relationships between miR-125a, miR-206 and PIK3CB are still not reported and verified.…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries)

Hou

Wang

et al. 2018

PLoS ONE

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Sheep are small ruminants, and their long intestines exhibit high digestive and absorptive capacity in many different rearing conditions; however, the genetic bases of this characteristic remains unclear. MicroRNAs (miRNAs) play a major role in maintaining both intestinal morphological structure as well as in regulating the physiological functions of this organ. However, no study has reported on the miRNA expression profile in the intestinal tissues of sheep. Here, we analyzed and identified the miRNA expression profile of three different intestinal tissues (i.e., duodenum, cecum, and colon) of sheep (Ovis aries) using high-throughput sequencing and bioinformatic methods. In total, 106 known miRNAs were identified, 458 conserved miRNAs were detected, 192 unannotated novel miRNAs were predicted, and 195 differentially expressed miRNAs were found between the different tissues. Additionally, 3,437 candidate target genes were predicted, and 17 non-redundant significantly enriched GO terms were identified using enrichment analysis. A total of 99 candidate target genes were found to significantly enriched in 4 KEGG biological pathways. A combined regulatory network was constructed based on 92 metabolism-related candidate target genes and 65 differentially expressed miRNAs, among which 7 miRNAs were identified as hub miRNAs. Via these mechanisms, miRNAs may play a role in maintaining intestinal homeostasis and metabolism. This study helps to further explain the mechanisms that underlie differences in tissue morphology and function in three intestinal segments of sheep.

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“…Furthermore, RNA was purified by proteinase K, and then extracted using the conventional TRIZOL method for reverse transcription, followed by the RT-qPCR analysis. 19…”

Section: Rna Immunoprecipitation (Rip) Assaymentioning

confidence: 99%

LncRNA TUG1 competitively binds to miR‐340 to accelerate myocardial ischemia‐reperfusion injury

Liu

et al. 2020

FASEB j.

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The aberrant expression of long noncoding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) has been previously associated with myocardial ischemia-reperfusion injury (MIRI), but the underlying molecular mechanisms remain elusive. The current study aimed to clarify the functional role of TUG1/microRNA (miR)-340/histone deacetylase 4 (HDAC4)/β-catenin/glucose transporter type 1 (GLUT1) axes in MIRI. The database-based analyses performed predicted the downstream factors of lncRNA TUG1. In the MIRI mouse models and hypoxia/reoxygenation (H/R)-induced cardiomyocyte models, the expression of TUG1/miR-340/HDAC4/β-catenin/GLUT1 was manipulated to examine their effects on the infarction area, cardiomyocyte viability and apoptosis employing the Evans blue/TTC double staining, CCK-8 and TUNEL assays. Furthermore, the dual luciferase reporter and RIP assays verified the binding affinity of miR-340 to TUG1 and HDAC4. Subsequently, a negative correlation between miR-340 and TUG1 or HDAC4 expression was identified in myocardial tissues of MIRI mice and H/R-induced cardiomyocyte models, along with a positive correlation between TUG1 and HDAC4. Additionally, it was established that TUG1 bound to miR-340, and miR-340 targeted HDAC4. TUG1 upregulated HDAC4 expression, thereby promoting MIRI in the mouse models. HDAC4 was proven to repress the expression of β-catenin and its target gene GLUT1. Moreover, the in vivo experiments validated that the inhibition of TUG1/miR-340/HDAC4/β-catenin/ GLUT1 axes alleviated MIRI in mice. Collectively, the current study uncovered the role of TUG1/miR-340/HDAC4/β-catenin/GLUT1 axes in MIRI mouse models and H/R-induced cardiomyocyte models which may be a potential therapeutic target for MIRI treatment.

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miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma

Cited by 25 publications

References 41 publications

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries)

LncRNA TUG1 competitively binds to miR‐340 to accelerate myocardial ischemia‐reperfusion injury

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