miR-1271 inhibits ERα expression and confers letrozole resistance in breast cancer

Yu, Tao; Yu, Hairu; Sun, Jiayi; Zhao, Zhao; Li, Shuang; Zhang, Xinfeng; Liao, Zhi-Xuan; Cui, Mingke; Li, Juan; Li, Chan; Zhang, Qiang

doi:10.18632/oncotarget.22359

Cited by 11 publications

(10 citation statements)

References 35 publications

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“…Moreover, adjacent normal breast tissues sampled at least 5 cm from primary tumors were obtained from 12 chemotherapy-naive BCa patients during mastectomy, and were used as controls. The clinical characteristics of BCa patients recruited in the current study was categorized according to the St. Gallen standards [14] and summarized in S1 Table.…”

Section: Methodsmentioning

confidence: 99%

“…Polymerase chain reaction (PCR) primers used for different targets were listed in S2 Table. Subsequent quantitative reverse transcription PCR (RT-qPCR) was performed using QuantiFast one-step SYBR Green RT-PCR kit in Applied Biosystems 7300 Real-Time PCR System (Foster City, CA), as described in our previous work [14]. 18S served as the internal control.…”

Section: Methodsmentioning

confidence: 99%

“…Tumor growth in nude mice was performed according to our previous work [14]. Briefly, BCa cells with different transfections were resuspended in Matrigel (10 mg/mL, BD Biosciences, Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

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Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells

Sun

et al. 2019

Cancer Res Treat

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells

Sun

et al. 2019

Cancer Res Treat

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“…Recent studies show that the impact of miR-1271 on the tumor is getting more and more attention. Many studies have found that miR-1271 has a wide range of tumor suppressor effects ( 18 – 20 ). MiR-1271 is down-regulated in many human tumors and is involved in the inhibition of tumor epithelial-mesenchymal transition (EMT), induction of apoptosis, and reversal of chemo-resistance ( 18 – 22 ).…”

Section: Introductionmentioning

confidence: 99%

Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271

Wang

Zhang

et al. 2018

Mol Med Report

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Emodin has a direct inhibitory effect on the growth and metastasis of a variety of malignant tumor cells. MicroRNA-1271 (miR-1271) has an extensive tumor-suppression effect by inhibiting epithelial mesenchymal transition (EMT) in tumor cells and induces tumor cell apoptosis. Proceeding with the EMT regulatory mechanism of pancreatic carcinoma, the present study aimed to examine the inhibitory effect of miR-1271 and emodin against invasion and metastasis of pancreatic carcinoma. The expression of EMT-related markers (E-cadherin, ZEB1 and TWIST1) was analyzed by western blotting. mRNA levels of miR-1271, E-cadherin, ZEB1 and TWIST1 in pancreatic tumor cells (SW1990) were measured through reverse transcription-quantitative polymerase chain reaction and cell invasiveness was detected using Transwell assays. In addition, a liver metastatic model was established with an implantation of pancreatic tumor tissue into the spleens of nude mice to study the effect of emodin on pancreatic cancer liver metastasis. In the present study, it was demonstrated that miR-1271 significantly decreased in pancreatic cancer cells and tissues. Twist1 may be a target gene of miR-1271. Emodin could inhibit the proliferation ability of pancreatic cancer cells and increased miR-1271 expression level. Further, we found that miR-1271 significantly inhibited SW1990 cell EMT and invasive ability. We also provided the evidence that emodin inhibited SW1990 cell EMT by raising the level of miR-1271. Moreover, the in vivo experiments have verified the inhibiting effect of emodin against liver metastasis of pancreatic cancer. The data in the present study indicated that emodin inhibited pancreatic cancer EMT and invasion by increasing the content of miR-1271.

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“…Moreover, miR-27a and miR-125a-3p sensitize breast cancer cells to endocrine therapy [77,78]. On the other hand, miR-1271 participates in letrozole resistance through the inhibition of ERα expression [79]. Finally, the ERα/miR-124/AKT2 axis is involved in the pathogenesis of breast cancer [80].…”

Section: Mirnas and Er Function In Cancersmentioning

confidence: 99%

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

Taheri

Shoorei

Dinger

et al. 2020

Cancers

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Estrogen receptors (ERs) comprise several nuclear and membrane-bound receptors with different tissue-specific functions. ERα and ERβ are two nuclear members of this family, whereas G protein-coupled estrogen receptor (GPER), ER-X, and Gq-coupled membrane estrogen receptor (Gq-mER) are membrane-bound G protein-coupled proteins. ERα participates in the development and function of several body organs such as the reproductive system, brain, heart and musculoskeletal systems. ERβ has a highly tissue-specific expression pattern, particularly in the female reproductive system, and exerts tumor-suppressive roles in some tissues. Recent studies have revealed functional links between both nuclear and membrane-bound ERs and non-coding RNAs. Several oncogenic lncRNAs and miRNAs have been shown to exert their effects through the modulation of the expression of ERs. Moreover, treatment with estradiol has been shown to alter the malignant behavior of cancer cells through functional axes composed of non-coding RNAs and ERs. The interaction between ERs and non-coding RNAs has functional relevance in several human pathologies associated with estrogen regulation, such as cancers, intervertebral disc degeneration, coronary heart disease and diabetes. In the current review, we summarize scientific literature on the role of miRNAs and lncRNAs on ER-associated signaling and related disorders.

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miR-1271 inhibits ERα expression and confers letrozole resistance in breast cancer

Cited by 11 publications

References 35 publications

Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells

Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells

Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

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