miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

Zhai, Jian; Qu, Shen; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

doi:10.1016/j.bbrc.2015.06.108

Cited by 40 publications

(31 citation statements)

References 23 publications

(22 reference statements)

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“…Additionally, miR-129-2 expression was found associated with advanced clinical TNM stage, lymph node metastasis and distal metastasis [56]. Similarly, Zhai et al proposed that miR-129 could suppress invasion by direct targeting PAK5 [64]. Meanwhile, it was also found that HCC patients with lower expression of miR-129 tended to have more advance stages and there is also noteworthy difference between the miR-129 expression in metastatic tumors and non-metastatic tumors.…”

Section: Mir-129 and Metastasismentioning

confidence: 86%

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MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Gao¹,

Feng²,

Han³

et al. 2016

Cell Physiol Biochem

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Emerging evidence has shown that microRNAs (miRNAs) play essential roles in regulating human cancers development and progression. However, the underlying mechanisms remain to be further explored. MiRNAs are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that moderate gene expression primarily at post-transcriptional level. There is a growing body of literature that recognizes the importance of microRNA (miR)-129 during the development of cancers. Aberrant expression of miR-129 has been detected in various types of human cancers and the validated target genes are involved in cancer-related biological processes such as DNA methylation, cell proliferation, apoptosis, cell cycle, and metastasis. In this review, we summarized the roles of miR-129 family members and their target genes in tumorigenesis and clinical treatment of human cancers, highlighting the potential roles of miR-129 as biomarkers for cancer diagnosis and prognosis, and promising tools for cancer treatment.

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Section: Mir-129 and Metastasismentioning

confidence: 86%

“…MiR-129 was found commonly down-regulated in HCC with ability of suppressing HCC cell proliferation. As the target gene of miR-129, PAK5, was frequently up-regulated and could promote cell viability [64]. Ectopic expression of miR-129-5p significantly suppressed cell viability in MTC cells through decreasing the…”

Section: Mir-129 and Cell Proliferationmentioning

confidence: 99%

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Gao¹,

Feng²,

Han³

et al. 2016

Cell Physiol Biochem

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“…PAK5, also known as PAK7, is upregulated by Aurora-A (He et al, 2014) and downregulated by miR-129 and miR-186 in certain cancer cells (Zhai J et al, 2015; Zheng J et al, 2015). Studies from Pak5- knockout mice show PAK5 has roles in mobility, learning, and memory related functions (Nekrasova et al, 2008; Furnari et al, 2013).…”

Section: Pak5/7 Biologymentioning

confidence: 99%

Structure, biochemistry, and biology of PAK kinases

Kumar

Sanawar

et al. 2017

Gene

181

192

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PAKs, p21-activated kinases, play central roles and act as converging junctions for discrete signals elicited on the cell surface and for a number of intracellular signaling cascades. PAKs phosphorylate a vast number of substrates and act by remodeling cytoskeleton, employing scaffolding, and relocating to distinct subcellular compartments. PAKs affect wide range of processes that are crucial to the cell from regulation of cell motility, survival, redox, metabolism, cell cycle, proliferation, transformation, stress, inflammation, to gene expression. Understandably, their dysregulation disrupts cellular homeostasis and severely impacts key cell functions, and many of those are implicated in a number of human diseases including cancers, neurological disorders, and cardiac disorders. Here we provide an overview of the members of the PAK family and their current status. We give special emphasis to PAK1 and PAK4, the prototypes of groups I and II, for their profound roles in cancer, the nervous system, and the heart. We also highlight other family members. We provide our perspective on the current advancements, their growing importance as strategic therapeutic targets, and our vision on the future of PAKs.

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“…An increasing number of studies have explored the association between cancer and miRNAs, and several miRNAs have been identified as biomarkers or therapeutic targets for a number of human cancers (14). Recent studies have demonstrated that miR-129 serves an important role in tumor cell growth and invasion in hepatocellular carcinoma (15) and in lung cancer cells (16). However, the role of miR-129 in prostate cancer remains largely elusive.…”

Section: Introductionmentioning

confidence: 99%

miR-129 predicts prognosis and inhibits cell growth in human prostate carcinoma

Zhang

et al. 2016

Molecular Medicine Reports

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MicroRNAs (miRNAs) are a class of small, well-conserved, non-coding RNAs that are increasingly identified as diagnostic and prognostic biomarkers in a number of cancers. Deregulated miR-129 is closely associated with tumorigenesis and cancer progression. However, the potential role of miR-129 in prostate cancer remains largely elusive. The present study investigated the role of miR-129 as a prognostic biomarker for tumor progression and clinical prognosis in prostate cancer patients. The examined prostate cancer tissues exhibited a significant reduction in miR-129 expression compared with the normal tissues (P=0.013). The expression levels of miR-129 were negatively correlated with histological grade (P<0.001), high preoperative prostate-specific antigen serum levels (P<0.001), pathological stage (P<0.001), high Gleason score (P<0.001), lymph node metastasis (P=0.002), angiolymphatic invasion (P=0.018), and biochemical recurrence (BCR; P=0.001). Use of the Kaplan-Meier analysis demonstrated that low miR-129 expression was closely associated with poorer BCR-free survival. Multivariate survival analysis indicated that miR-129 expression may be an independent prognostic marker for BCR-free survival in prostate cancer patients (P<0.001). Overexpression of miR-129 markedly attenuated prostate cancer cell growth by rescuing cell cycle-regulated protein expression. The present study suggests that miR-129 is downregulated in the cancerous tissues of prostate cancer patients, which was associated with poor BCR-free survival. Thus, it may be considered as a novel independent prognostic biomarker for prostate cancer. In addition, downregulation of miR-129 may serve a critical role in the proliferation of prostate cancer cells.

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miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

Cited by 40 publications

References 23 publications

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Structure, biochemistry, and biology of PAK kinases

miR-129 predicts prognosis and inhibits cell growth in human prostate carcinoma

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