miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

Luo, Hailan; Guo, Wentao; Wang, Fei; You, Yanjie; Wang, Jianguo; Chen, Xudong; Wang, Jihong; Wang, Yuanyuan; Du, Yuwen; Chen, Xiaonan; Xue, Changgui; Song, Guohua; Wang, Fuqing

doi:10.3892/or.2015.4206

Cited by 34 publications

(37 citation statements)

References 40 publications

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“…This study design is distinguished from our recent report that involves the use of different mice for xenograft tumor study [32], and current tumor mouse model not only allows the reduction of number of experimental animals for research but also minimizes interindividual variability and other confounding factors. Nevertheless, consistent results are obtained from present and previous studies [31, 32, 34, 42], indicating that miR-1291 acts as a tumor suppressor in renal, esophageal squamous, and pancreatic cancer cells.…”

Section: Discussionsupporting

confidence: 92%

“…Recent studies have showed that miR-1291 level is lower in renal cell carcinoma specimens [33] and esophageal squamous cell carcinoma [42], and restoration of miR-1291 suppresses renal and esophageal squamous cancer cell proliferation, migration and invasion [34, 42]. The present study is the first to find that miR-1291 is significantly downregulated in patient pancreatic carcinoma tissues and pancreatic cancer cell lines.…”

Section: Discussionsupporting

confidence: 55%

“…Several targets identified for miR-1291 thus far include the efflux transporter ABCC1 underlying multidrug resistance [30], the endoplasmic reticulum stress sensor IRE1α and consequently glypican-3 (GPC3) implied in liver carcinogenesis [43, 44], glucose transporter protein type 1 (GLUT1/SLC2A1) critical for cell metabolism [34], and mucin 1 (MUC1) making up mucus [42]. Our recent metabolomics study have revealed nicotinamide N -methyltransferase (NNMT), an enzyme participating in nicotinate and nicotinamide metabolism, as a biomarker for miR-1291-altered pancreatic cancer cell metabolome [32].…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis

Pan

Qiu

et al. 2016

Oncotarget

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Pancreatic cancer is the fourth leading cause of cancer death in the United States. Better understanding of pancreatic cancer biology may help identify new oncotargets towards more effective therapies. This study investigated the mechanistic actions of microRNA-1291 (miR-1291) in the suppression of pancreatic tumorigenesis. Our data showed that miR-1291 was downregulated in a set of clinical pancreatic carcinoma specimens and human pancreatic cancer cell lines. Restoration of miR-1291 expression inhibited pancreatic cancer cell proliferation, which was associated with cell cycle arrest and enhanced apoptosis. Furthermore, miR-1291 sharply suppressed the tumorigenicity of PANC-1 cells in mouse models. A proteomic profiling study revealed 32 proteins altered over 2-fold in miR-1291-expressing PANC-1 cells that could be assembled into multiple critical pathways for cancer. Among them anterior gradient 2 (AGR2) was reduced to the greatest degree. Through computational and experimental studies we further identified that forkhead box protein A2 (FOXA2), a transcription factor governing AGR2 expression, was a direct target of miR-1291. These results connect miR-1291 to the FOXA2-AGR2 regulatory pathway in the suppression of pancreatic cancer cell proliferation and tumorigenesis, providing new insight into the development of miRNA-based therapy to combat pancreatic cancer.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis

Pan

Qiu

et al. 2016

Oncotarget

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“…On the other hand, we found eight down-regulated miRNAs, some of them implicated in multiple processes such as cancer ( miR20b-5p , miR-1291 ) 52, 53 , organ injury in toxicity drug models ( miR-382-5p ) 54 , metabolic processes and steroidogenesis ( miR-378b ) 55 , and tissue inflammation ( miR-3085-3p ) 56 . None of them has been studied in the context of testes physiology.…”

Section: Discussionmentioning

confidence: 91%

Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction

Buñay

Larriba

Moreno

et al. 2017

Sci Rep

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Humans are environmentally exposed not only to single endocrine-disrupting chemicals (EDCs) but to mixtures that affect their reproductive health. In reproductive tissues, microRNAs (miRNAs) are emerging as key targets of EDCs. Here, we analysed changes in the testis “miRNome” (and their biogenesis mechanism) in chronically exposed adult mice to a cocktail of five EDCs containing 0.3 mg/kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP) and 0.05 mg/kg-BW/day of each alkylphenol (NP, OP), from conception to adulthood. The testis “miRNome” was characterised using next-generation sequencing (NGS). Expression levels of genes involved in miRNA biogenesis were measured by RT-qPCR, as well as several physiological and cytological parameters. We found two up-regulated, and eight down-regulated miRNAs and thirty-six differentially expressed isomiRs along with an over-expression of Drosha, Adar and Zcchc11. A significant decrease of intratesticular estradiol but not testosterone was detected. Functional analysis showed altered spermatogenesis, germ cell apoptosis and negative correlation of miR-18a-5p with Nr1h2 involved in the deregulation of the steroidogenesis pathway. Here, we present the first association between miRNA/isomiRs deregulation, their mechanisms of biogenesis and histopathological and hormonal alterations in testes of adult mice exposed to a mixture of low-dose EDCs, which can play a role in male infertility.

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“…miR-3653 is upregulated in cervical cancer tissues associated with human papillomavirus (HPV) infection as compared with paired normal tissues 25 . miR-1291 promotes apoptosis in esophageal squamous cell carcinoma by targeting mucin1 26 . Third, these six miRNAs were detected in a panel of 5-FU-resistant colon cancer cell lines by qRT-PCR to identify chemoresistance-related miRNAs.…”

Section: Discussionmentioning

confidence: 99%

miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2

Jiang

Shao

et al. 2017

Molecular Therapy - Nucleic Acids

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5-Fluorouracil (5FU)-based adjuvant therapy is the first-line therapy for treating stage II and III colon cancer after surgery. However, its therapeutic efficacy is limited because of chemoresistance, especially in deficient mismatch repair (dMMR) colon cancer. Here, we first used laser capture microdissection to obtain purified cells from four dMMR and four proficient mismatch repair (pMMR) colon cancer tissues. Second, microRNA (miRNA) microarray chips were used to identify miRNAs that are differentially expressed between these two classes of tumors. Third, we analyzed their differential expression by qRT-PCR in a panel of 5-FU-resistant colon cancer cell lines. We identified that miR-1290 was one of the most upregulated miRNAs in both dMMR colon cancer tissues and 5-FU-resistant cells. We also found that miR-1290 was positively correlated with dMMR status and predicted poor prognosis in stage II and III colon cancer patients who received 5-FU-based chemotherapy. Furthermore, we demonstrated that inhibition of the expression of miR-1290 enhanced sensitivity to 5-FU treatment in vitro and in tumor xenografts in vivo by direct targeting hMSH2. Our study indicates that miR-1290 may become a promising biomarker of dMMR colon cancer and predicts the prognosis of stage II and III patients who receive 5-FU-based adjuvant therapy.

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miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

Cited by 34 publications

References 40 publications

MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis

MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis

Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction

miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2

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