miR-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pCaMKII and BAI3 in the hippocampus of APP/PS1 transgenic mice

Fu, Chang‐Hai; Han, Xueyan; Tong, Lei; Nie, Peng-Yin; Hu, Yanrong; Ji, Lili

doi:10.1016/j.bbr.2021.113485

Cited by 13 publications

(13 citation statements)

References 47 publications

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“…We also discovered a significant decrease in hsa-miR-142-5p expression in male AD patients. Hsa-miR-142-5p had been previously related to spatial learning and memory in AD animal models [64,65][65,66], suggesting a potential target for AD treatment.…”

Section: Discussionmentioning

confidence: 99%

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

Llera-Oyola,

Carceller,

Andreu

et al. 2023

Preprint

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Background: Alzheimer's disease (AD) is the most frequent cause of dementia and its incidence is expected to rise as the life expectancy of the population increases. Sex-based differences in AD development have been described, although there are still uncertainties on the role of biological sex in molecular mechanisms of the disease. The study of sex-specific expression profiles of regulatory elements, such as microRNAs (miRNAs), could contribute to a more accurate diagnosis and treatment of the disease. Methods: We conducted a systematic review identifying five studies of microRNA expression in AD that incorporated the biological sex of the samples published in the Gene Expression Omnibus (GEO) repository. Differential expression analyses were performed for each study, considering both disease and biological sex of patients. Subsequently, results were integrated with a meta-analysis methodology. Finally, functional enrichment of the meta-analyses results was performed to establish an association between altered miRNA expression and relevant terms of the Gene Ontology (GO). Results: Meta-analyses of miRNAs expression in blood samples revealed 16 and 22 miRNAs altered in females and males, respectively. Moreover, 9 miRNAs were commonly overexpressed in both sexes, unveiling common miRNAs dysregulation profiles. In contrast, functional enrichment revealed sex-differences in biological processes altered. In males, most of the affected processes were related to ubiquitination, regulation of different kinase activities and apoptotic processes; but in females were linked to RNA splicing and translation. Meta-analyses of brain samples also revealed some alterations in miRNAs expression (6 in females and 4 in males). The unique miRNA altered in both sexes (miR-767-5p) was underexpressed in both males and females. Nonetheless, the functional enrichment analysis did not reveal any affected biological process. Conclusions: Sex-specific meta-analyses allowed for the detection of differentially expressed miRNAs in females and males. Identification of deregulated miRNAs highlighted the relevance of the sex information in biomedical data. Further studies centered on miRNA regulation should meet criteria for comparability and standardization of information.

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Section: Discussionmentioning

confidence: 99%

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

Llera-Oyola,

Carceller,

Andreu

et al. 2023

Preprint

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“…BAI3 was a direct target of miR‐142‐5p, 81 and PTPN1 was also a direct target of miR‐142‐5p 82 . MiR‐142‐5p‐PTPN1 axis and MiR‐142‐5p‐BAI3 axis promoted cell apoptosis in AD rats and Aβ 42 ‐induced HT‐22 cells, respectively 81,82 . In contrast, miR‐107 was downregulated in APP/PS1 double transgenic mice 83 and 6‐hydroxydopamine (6‐OHDA)‐insulted mice 84 .…”

Section: Abnormally Expressed Ncrnas In Ad Animal Models In Regulatin...mentioning

confidence: 99%

“…85,86 Table S2 summarizes all the cell apoptosis-related and abnormally expressed miRNAs in multiple AD animal models. 80,81, These miRNAs can form 'miRNA-mRNA' axis in regulating cell apoptosis in AD.…”

Section: Mirna-mrnamentioning

confidence: 99%

NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease

Li,

Jin,

Tan

et al. 2023

CNS Neurosci Ther

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AimsThe aim of this review is to systematically summarize and analyze the noncoding RNAs (ncRNAs), especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in the cell apoptosis among Alzheimer's disease (AD) in recent years to demonstrate their value in the diagnosis and treatment of AD.MethodsWe systematically summarized in vitro and in vivo studies focusing on the ncRNAs in the regulation of cell apoptosis among AD in PubMed, ScienceDirect, and Google Scholar.ResultsWe discover three patterns of ncRNAs (including ‘miRNA‐mRNA’, ‘lncRNA‐miRNA‐mRNA’, and ‘circRNA‐miRNA‐mRNA’) form the ncRNA‐based regulatory networks in regulating cell apoptosis in AD.ConclusionsThis review provides a future diagnosis and treatment strategy for AD patients based on ncRNAs.

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“…Numerous studies have suggested that miR-142-5p and miR-134-5p are closely related to nervous system diseases and peripheral nerve injury [33][34][35][36][37][38] . Previous studies have con rmed that MiR-142-5p plays a role in protecting nerves and promoting nerve repair by regulating the viability and apoptosis of neuronal cells during nerve injury repair 24 .…”

Section: Mir-134-5p Promotes the Proliferation And Migration Of Schwa...mentioning

confidence: 99%

Analysis of miRNA expression profile of sciatic nerve in rats with spinal cord injury

Jiang

Zhang

et al. 2023

Preprint

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After spinal cord injury, the downstream peripheral nerves lose control, and the tissues lose the protection of peripheral nerves, which is easy to cause skin and soft tissue injury and wound difficult to heal. However, the underlying mechanisms are still unknown. In order to explore the mechanism of functional changes in peripheral nerves deprived of spinal cord control, we established a model of sciatic nerve transection injury combined with spinal cord transection injury in Sprague-Dawley (SD) rats, and small RNA sequencing analysis, tissue staining and molecular experiments were used to analyze the changes in miRNA expression and degeneration of peripheral nerve stump. The results showed that after loss of spinal cord innervation, the response of rats to sciatic nerve injury was weakened, and Wallerian degeneration could not occur normally and angiogenesis was abnormal. Moreover, differentially expressed miRNAs were detected in the sciatic nerve stump of the two groups of rats with or without spinal cord injury. Specifically, miR-134-5p and miR-142-5p were decreased in the sciatic nerve stump after spinal cord injury. Therefore, we suggest that spinal cord injury may inhibit the repair process of sciatic nerve injury by down-regulating the expression of miR-134-5p / miR-142-5p.

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miR-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pCaMKII and BAI3 in the hippocampus of APP/PS1 transgenic mice

Cited by 13 publications

References 47 publications

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease

Analysis of miRNA expression profile of sciatic nerve in rats with spinal cord injury

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