MiR-143 inhibits endometrial cancer cell proliferation and metastasis by targeting<i>MAPK1</i>

Chang, Lei; Zhang, Dongya; Shi, Huirong; Bian, Yangyang; Guo, Ruixia

doi:10.18632/oncotarget.21037

Cited by 41 publications

(26 citation statements)

References 44 publications

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“…Hu et al shed light on the role of miR-585 in targeting MAPK1 and inhibiting gastric cancer cell proliferation and migration [29]. Furthermore, Chang et al applied a series of assays to witness that miR-143 might suppress the proliferation, migration and invasive ability of Endometrial cancer (EC) cells while promote the EC cells apoptosis by decreasing MAPK1 [30].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622

Zou

Luo

et al. 2019

Cell Cycle

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The present research was major in investigating the regulation association among hsa_circ_0101432 (has_circ_RPPH1), miR-1258, miR-622 and MAPK1 in hepatocellular carcinoma (HCC), and we explored the mechanism underlying pathogenesis of HCC. Microarray analysis was employed to detect hsa_-circ_0101432 expression in HCC. Hsa_circ_0101432 was verified as a circRNA by testing divergent primers and RNase R. And qRT-PCR was performed to determine the expression of hsa_circ_0101432, miR-1258, miR-622 and MAPK1 mRNA. Furthermore, miRanda predicted that mRNAs targeted miR-1258 and miR-622. CCK-8 assay, colony formation assay, flow cytometry as well as transwell assay were performed to detect cell viability, proliferation, apoptosis and invasive ability, respectively. Xenograft in nude mice was applied to observe tumor growth in vivo. Up-regulated hsa_circ_0101432 and downregulated miR-1258 and miR-622 were detected in HCC while Hsa_circ_0101432 enhanced expression of MAPK1 mRNA by targeting miR-1258 and miR-622. Knocking down hsa_circ_0101432 or overexpressing miR-1258 and miR-622 inhibited proliferation and invasive ability of HCC cell and promoted cell apoptosis. Hsa_circ_0101432 was confirmed to promote tumor growth via inhibiting miR-1258 and miR-622 expression and promoting MAPK1 mRNA expression by in vivo experiment. Hsa_circ_0101432 inhibited HCC cell apoptosis, promoted cell proliferation, invasive ability and HCC tumor growth by targeting miR-1258 and miR-622 and upregulating MAPK1 mRNA expression.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622

Zou

Luo

et al. 2019

Cell Cycle

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“…As mentioned above, the MAPK/ERK signaling pathway is a key signaling pathway of RAS networks, which play a role in metastasis. In endometrial cancer (EC), the downregulation of MAPK1 was observed with the ectopic expression of MIR143 and the suppression of invasion and migration was observed 63 …”

Section: The Role Of Mir143‐3p On Rat Sarcoma Signaling Network In Vmentioning

confidence: 99%

Effects of MIR143 on rat sarcoma signaling networks in solid tumors: A brief overview

et al. 2020

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This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. AbstractRat sarcoma (RAS) is a well-known oncogene that plays important roles in cancer proliferation, cell survival and cell invasion. RAS exists as three major isoforms, Kirsten rat sarcoma (KRAS), Harvey rat sarcoma (HRAS) and neuroblastoma rat sarcoma (NRAS). Mutations of these genes account for approximately 30% of all cancers.Among them, KRAS mutations are the most common, responsible for 85%, followed by NRAS (12%) and HRAS (3%). Although the development of RAS inhibitors has been explored for over the past decade, so far, no effective inhibitor has been found.MicroRNA (miRNA) are a class of small non-coding RNA that control the gene expression of pleural target genes at the post-transcriptional level. MiRNA play critical roles in the physiological and pathological processes at work in cancers, such as cell proliferation, cell death, cell invasion and metastasis. MicroRNA-143 (MIR143) is known to function as a tumor suppressor in a variety of cancers. One of its known mechanisms is suppression of RAS expression and its effector signaling pathways, such as PI3K/AKT and MAPK/ERK. Within the last five years, we developed a potent chemically modified MIR143-3p that enabled us to elucidate the details of the KRAS signaling networks at play in colon and other cancer cells. In this review, we will discuss the role of MIR143-3p in those RAS signaling networks that are related to various biological processes of cancer cells. In addition, we will discuss the possibility of the use of MIR143 as a therapeutic drug for targeting RAS signaling networks. K E Y W O R D S AKT, ERK, KRAS positive circuit, MAPK, MIR143, PI3K, RAS | 1077 TOKUMARU eT Al.

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“…In summary, a lot of miRNAs, cellular and circulating, have been found dysregulated in endometrial cancer and a comprehensive list and the relative references are reported in Table 2 [ 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ].…”

Section: Ncrnas and Endometrial Cancermentioning

confidence: 99%

Non-Coding RNAs in Endometrial Physiopathology

Ferlita

Battaglia

Andronico

et al. 2018

IJMS

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The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.

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MiR-143 inhibits endometrial cancer cell proliferation and metastasis by targetingMAPK1

Cited by 41 publications

References 44 publications

RETRACTED ARTICLE: Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622

RETRACTED ARTICLE: Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622

Effects of MIR143 on rat sarcoma signaling networks in solid tumors: A brief overview

Non-Coding RNAs in Endometrial Physiopathology

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