miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury

Shi, Jing; Bei, Yihua; Kong, Xiangqing; Liu, Xiaojun; Lei, Zhiyong; Xu, Tianzhao; Wang, Hui; Xuan, Qinkao; Chen, Ping; Xu, Jiahong; Lin, Chen; Liu, Hui; Zhong, Jiuchang; Sluijter, Joost P.G.; Li, Xinli; Rosenzweig, Anthony; Xiao, Junjie

doi:10.7150/thno.15162

Cited by 185 publications

(246 citation statements)

References 28 publications

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“…The protective effects of exercise against cardiac I/R injury have been well acknowledged [19, 31, 38, 50], which could be associated with reduced myocardial inflammation, minimized oxidative and nitric-oxidative stress, decreased cardiomyocyte apoptosis, and promoted angiogenesis. It was recently reported that exercise is able to enhance cardiomyocyte renewal [34, 42], which is necessary to mediate the protective effect of exercise against I/R injury [5]. Moreover, exercise is efficient to reduce cardiac I/R injury both at baseline and in obese diabetic condition, though different molecular mechanisms might be involved [9, 29].…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

et al. 2017

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Extracellular vesicles (EVs) serve an import ant function as mediators of intercellular communication. Exercise is protective for the heart, although the signaling mechanisms that mediate this cardioprotection have not been fully elucidated. Here using a nano-flow cytometry, we found a rapid increase in plasma EVs in human subjects undergoing exercise stress testing. We subsequently identified that serum EVs were increased by ~1.85 fold in mice after 3-week swimming. Intramyocardial injection of equivalent quantities of EVs from exercised mice and non-exercised controls provided similar protective effects against acute ischemia/reperfusion (I/R) injury in mice. However, injection of exercise-induced EVs in a quantity equivalent to the increase seen with exercise (1.85 Swim group) significantly enhanced the protective effect. Similarly, treatment with exercise-induced increased EVs provided additional anti-apoptotic effect in H2O2-treated H9C2 cardiomyocytes mediated by the activation of ERK1/2 and HSP27 signaling. Finally, by treating H9C2 cells with insulin-like growth factor-1 (IGF-1) to mimic exercise stimulus in vitro, we found an increased release of EVs from cardiomyocytes associated with ALIX and RAB35 activation. Collectively, our results show that exercise-induced increase in circulating EVs enhances the protective effects of endogenous EVs against cardiac I/R injury. Exercise-derived EVs might serve as a potent therapy for myocardial injury in the future.

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Section: Discussionmentioning

confidence: 99%

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

et al. 2017

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“…Several miRNAs reduce the expression of antihypertrophic factors and indirectly contribute to elevation of pathological hypertrophy. MiR-297 negatively regulates the expression of Sigma-1 receptor (Sig-1R) and activates ER stress signaling [30], while miR-17-3p targets metallopeptidase inhibitor 3 (TIMP3), a negative regulator of PTEN-Akt pathway, and resulting in cardiomyocyte hypertrophy [31]. MiR-21 targets suppressors of hypertrophic response by inhibiting translation of SH3 domain-containing protein 2 (SORBS2), PDZ, and LIM domain 5 (PDLIM5) [32].…”

Section: Mirna and Cardiac Hypertrophymentioning

confidence: 99%

MicroRNA as a Therapeutic Target in Cardiac Remodeling

Chen

Ponnusamy

Liu

et al. 2017

BioMed Research International

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MicroRNAs (miRNAs) are small RNA molecules that contain 18–25 nucleotides. The alterations in their expression level play crucial role in the development of many disorders including heart diseases. Myocardial remodeling is the final pathological consequence of a variety of myocardial diseases. miRNAs have central role in regulating pathogenesis of myocardial remodeling by modulating cardiac hypertrophy, cardiomyocytes injury, cardiac fibrosis, angiogenesis, and inflammatory response through multiple mechanisms. The balancing and tight regulation of different miRNAs is a key to drive the cellular events towards functional recovery and any fall in this leads to detrimental effect on cardiac function following various insults. In this review, we discuss the impact of alterations of miRNAs expression on cardiac hypertrophy, cardiomyocytes injury, cardiac fibrosis, angiogenesis, and inflammatory response. We have also described the targets (receptors, signaling molecules, transcription factors, etc.) of miRNAs on which they act to promote or attenuate cardiac remodeling processes in different type cells of cardiac tissues.

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“…The miR-17-92 cluster plays a critical role in cardiomyocyte proliferation (Gao et al, 2019) and affects the development of various diseases by regulating many related cellular processes and multiple target genes, including neurological diseases and cardiac diseases (Bai et al, 2019). The members of the miR-17-92 cluster and the expression of their passenger miRNAs expressions promote exercise-induced cardiac growth and reduce adverse ventricular remodeling (Shi et al, 2017). Cardiac rehabilitation will contribute in protecting against the development of depression and anxiety (Zheng et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The 24-Form Tai Chi Improves Anxiety and Depression and Upregulates miR-17-92 in Coronary Heart Disease Patients After Percutaneous Coronary Intervention

Liu

et al. 2020

Front. Physiol.

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Background: Anxiety and depression are common symptoms in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). The 24-form Tai Chi may exert a protective function for CHD patients after PCI by improving anxiety and depression.Methods: Patients who received PCI after 1-4 days were randomly assigned to the 24-form Tai Chi group (TG) and the control group (CG). The differences in anxiety and depression, using the Medical Outcomes Study 36−item Short−Form Health Survey (SF-36), before and after an average of 10 months of Tai Chi intervention were compared in both groups to analyze the effects of Tai Chi on the emotion and the life quality of CHD patients. Meanwhile, the relative levels of miR-17-92 were measured by using real-time qPCR. The association between the relative levels of miR-17-92 and the anxiety and the depression of CHD patients after PCI was analyzed. Adjusted Cox models were used to explore the effect of Tai Chi exercise in CHD patients.Results: After 10 months of intervention, the changes in the anxiety subscale (P = 0.002), in the depression subscale (P = 0.008), and in the stress (P = 0.015) scores were higher in the TG group when compared to those of the CG group. The proportion of anxious (P = 0.045) and depressed subjects (P = 0.042) in the TG group was lower than that in the CG group. On the other hand, the increase in the SF-36 scores and in the relative levels of miR-17-92 was significantly higher in the TG group when compared with that of the CG group (P < 0.05). The serum level of miR-17-92 had a negative correlation with the anxiety, the depression, and the stress scores (P < 0.01). Conclusion:The 24-form Tai Chi improved the anxiety and the depression symptoms and upregulated the miR-17-92 levels in CHD patients after PCI.

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miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury

Cited by 185 publications

References 28 publications

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

MicroRNA as a Therapeutic Target in Cardiac Remodeling

The 24-Form Tai Chi Improves Anxiety and Depression and Upregulates miR-17-92 in Coronary Heart Disease Patients After Percutaneous Coronary Intervention

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