miR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2

Li, Wang; Cui, Xu; Qi, Anlong; Yan, Long; Wang, Tong; Li, Bin

doi:10.1016/j.prp.2019.152636

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…It has been reported that miR-10a-5p directly targets MAPK8IP1 as a major mechanism for gastric cancer metastasis [23]. Recent studies have demonstrated that EEF2 inhibited lung cancer cell proliferation, and miR-183-5p, a potential prognostic biomarker, regulates cell functions by modulating EEF2 in gastric cancer [24,25]. This proposed role is consistent with our findings.…”

Section: Discussionsupporting

confidence: 92%

Identification of Autophagy‐Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low‐Grade Gliomas

Quan

Xiong

et al. 2021

BioMed Research International

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Autophagy plays an important role in cancer. Many studies have demonstrated that autophagy-related genes (ARGs) can act as a prognostic signature for some cancers, but little has been known in low-grade gliomas (LGG). In our study, we aimed to establish a prognostical model based on ARGs and find prognostic risk-related key genes in LGG. In the present study, a prognostic signature was constructed based on a total of 8 ARGs (MAPK8IP1, EEF2, GRID2, BIRC5, DLC1, NAMPT, GRID1, and TP73). It was revealed that the higher the risk score, the worse was the prognosis. Time-dependent ROC analysis showed that the risk score could precisely predict the prognosis of LGG patients. Additionally, four key genes (TGFβ2, SERPING1, SERPINE1, and TIMP1) were identified and found significantly associated with OS of LGG patients. Besides, they were also discovered to be strongly related to six types of immune cells which infiltrated in LGG tumor. Taken together, the present study demonstrated the promising potential of the ARG risk score formula as an independent factor for LGG prediction. It also provided the autophagy-related signature of prognosis and potential therapeutic targets for the treatment of LGG.

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Section: Discussionsupporting

confidence: 92%

Identification of Autophagy‐Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low‐Grade Gliomas

Quan

Xiong

et al. 2021

BioMed Research International

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“…The oncogenic role of miR-183-5p in some other cancers has been confirmed previously. For example, miR-183-5p has been identified as a potential prognostic biomarker that is capable of predicting worse survival in patients with gastric cancer 11 and renal cell cancer. 13 Miao and colleagues have reported that miR-183-5p overexpression can promote the proliferation, invasion and metastasis of pancreatic adenocarcinoma cells.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] Moreover, there has been an increased understanding on the diagnostic, prognostic, and biological functions of miRNAs in osteosarcoma patients. 9,10 As one of the vital members of the miR-183 family, miR-183-5p located on human chromosome 7 has been widely reported as an oncogene in many cancer types, such as gastric cancer, 11 hepatocellular carcinoma, prostate cancer, 12 renal cell cancer 13 and breast cancer. 14 In addition, miR-183-5p has been proposed to play a tumor suppressor role in other cancers, including lung cancer, 15 cervical cancer, 16 endometrial cancer 17 and acute myeloid leukemia.…”

Section: Introductionmentioning

confidence: 99%

MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients

Lin

Luo

Zhao

et al. 2021

CMAR

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Background Although miRNA-183-5p plays a critical role in many cancer types, including gastric cancer, hepatocellular carcinoma, prostate cancer, renal cell cancer and breast cancer, its role in osteosarcoma remains unclear. Methods Expression levels of miR-183-5p were detected in osteosarcoma tissues and cell lines using qRT-PCR. The effect of miR-183-5p on the survival and recurrence of osteosarcoma patients was analyzed in a cohort of 80 patients using Kaplan–Meier curves and Cox regression analysis. Effects of miR-183-5p on cell proliferation, migration and invasion abilities were evaluated using CCK-8, crystal violet and transwell assays. Results The expression of miR-183-5p was found to be upregulated in human osteosarcoma tissues and cell lines. Moreover, miR-183-5p expression was observed to be closely associated with tumor size, TNM stage and lung metastasis. Notably, high expression of miR-183-5p was shown to be able to predict unfavorable clinical prognosis in osteosarcoma patients. Additionally, whilst overexpression of miR-183-5p was observed to significantly promote the proliferation, migration and invasion of osteosarcoma cells; an inhibitory effect was observed with knockdown of miR-183-5p. Conclusion This study demonstrated that miR-183-5p acts as an oncogene and plays a critical role in the regulation of osteosarcoma tumor progression, and our results suggest a novel potential prognostic and therapeutic value of miR-183-5p in osteosarcoma.

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“…miR183-5p, a mature spliceosome of miR183 abnormally expressed in various diseases, [12][13][14] acts as both a tumor promoter to induce tumor formation and a tumor suppressor to prevent tumor progression. [15][16][17][18] FOXO1 contains four functional domains -nuclear localization signal, transactivation (TA), nuclear export signal, and Forkhead (FKH) -and participates in cell physiological and biochemical processes of apoptosis, metabolism, and antioxidant stress. 19 Therefore, uncontrolled expression of FOXO1 may induce an increase in malignant cell behavior.…”

Section: Introductionmentioning

confidence: 99%

<p>LncRNA <em>SNHG16</em> Regulates the Progress of Acute Myeloid Leukemia Through miR183-5p–FOXO1 Axis</p>

Yang¹,

Hee²,

Wu³

et al. 2020

OTT

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Purpose At present, there is a lack of precise knowledge on acute myeloid leukemia (AML) at the molecular level, and understanding its occurrence at the genetic level is conducive to the development of targeted therapies. Therefore, in this study the relationship between the lncRNA SNHG1 –miR183-5p–FOXO1 axis and AML was explored. Methods Expression of lncRNA SNHG16 and miR183-5p was quantified by quantitative real-time PCR, and the level of FOXO1 and other proteins was measured by Western blot. Expression vectors of lncRNA SNHG16 , miR183-5p, and FOXO1 were constructed to assess effects of the three on cell proliferation and apoptosis. MTT reduction assays were employed for cell proliferation, flow cytometry for cell cycle and apoptosis, and dual luciferase–reporter assays for the targeting relationship between lncRNA SNHG16 and miR183-5p and miR183-5p and FOXO1. Results lncRNA SNHG16 was highly expressed in peripheral blood/leukemia cell lines of patients with AML compared with normal human peripheral blood/peripheral blood mononuclear cells. miR183-5p was the target of lncRNA SNHG16 and FOXO1 the target gene of miR183-5p rather than lncRNA SNHG16. Absence of lncRNA SNHG16 led to upregulation of miR183-5p, promotion of apoptosis, and inhibition of proliferation. Suppression of miR183-5p accelerated cell proliferation and hindered apoptosis. miR183-5p negatively regulated FOXO1, and FOXO1 promoted proliferation and inhibited apoptosis. Inhibition of miR183-5p counteracted the changes caused by lncRNA SNHG16 absence. Conclusion lncRNA SNHG16 regulates the progress of AML via the miR183-5p–FOXO1 axis.

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miR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2

Cited by 15 publications

References 31 publications

Identification of Autophagy‐Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low‐Grade Gliomas

Identification of Autophagy‐Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low‐Grade Gliomas

MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients

<p>LncRNA <em>SNHG16</em> Regulates the Progress of Acute Myeloid Leukemia Through miR183-5p–FOXO1 Axis</p>

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