miR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects

Wang, Pingyu; Xie, Songqiang; Cui, Aidong; Zhang, Yanxiang; Jiang, Baofa

doi:10.3892/etm.2011.399

Cited by 16 publications

(19 citation statements)

References 41 publications

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“…of human genome [10]. Recently, various studies focused on the pre-miRNA polymorphisms located on the stem-loop, such as pre-mir-196a2 rs11614913 [20], pre-mir-146a rs2910164 [21], pre-mir-499 rs3746444 [22,23]. In the present study, the G allele of pre-let7d rs10993081 was found to contribute an independent increased risk for MetS and this association may be partially due to its effect on glucose metabolism.…”

Section: Fig 3 Interaction Dendrogramsupporting

confidence: 48%

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Yan

Zhang

et al. 2015

Endocr J

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MicroRNA (miRNA) related genetic variation may change miRNA binding affinity and mRNA expression levels of the target genes, thus leading to altered metabolic parameters. This study explored the influence of let-7 related single nucleotide polymorphisms (SNPs) on individual susceptibility to metabolic syndrome (MetS) in a Chinese population. Seven SNPs located at the pri-let-7 gene region, pre-let-7 gene region or 3’-UTR of the KRAS gene were selected. The SNPs were genotyped in 503 MetS patients and 529 normal controls using the high-throughput Sequenom genotyping platform. Unconditional logistic regression analysis was utilized to estimate the association between these SNPs and the risk of MetS. There are three SNPs significantly associated with MetS. The A allele of rs17276588 was associated with an increased risk effect for MetS (Adjusted OR=1.75, 95%CI 1.37-2.25,

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Section: Fig 3 Interaction Dendrogramsupporting

confidence: 48%

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Yan

Zhang

et al. 2015

Endocr J

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“…Several molecular epidemiological studies have investigated the association between the miR-149 rs2292832 polymorphism and cancer (Ding et al, 2013;Dominguez 2013), and the association of miR-149 rs2292832 polymorphism with cancer risks (Hu et al, 2009;Tian et al, 2009;Tu et al, 2012;Wang et al, 2012;Hong et al, 2013) have been conducted. But the conclusions are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility

Du¹,

Ma²,

Zhao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Two of them investigated rs2910164 in miR-146a [19], [22] while four studies focused on rs11614913 in miR-196a2 [18], [21], [23], [25]. Meta-analyses from Tian et al [24] and Xu et al [20] covered both of the two SNPs.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association of Two Common Polymorphisms rs2910164 and rs11614913 with Susceptibility to Hepatocellular Carcinoma: A Meta-Analysis

et al. 2012

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BackgroundSingle nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the process of carcinogenesis by altering the expression of tumor-related microRNAs. It has been suggested that two common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to hepatocellular carcinoma (HCC). However, published results are inconsistent and inconclusive. In the present study, we performed a meta-analysis to systematically summarize the possible association between the two SNPs and the risk for HCC.Methodology/Principal FindingsWe conducted a search of case-control studies on the associations of SNPs rs2910164 and/or rs11614913 with susceptibility to HCC in PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, ScienceDirect, Wiley Online Library and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. HCC risk associated with the two polymorphisms was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). 5 studies on rs2910164 and 4 studies on rs11614913 were included in our meta-analysis. Our results showed that neither allele frequency nor genotype distribution of the two polymorphisms was associated with risk for HCC in all genetic models. Similarly, subgroup analysis in Chinese population showed no association between the two SNPs and the susceptibility to HCC.Conclusions/SignificanceThis meta-analysis suggests that two common SNPs rs2910164 and rs11614913 are not associated with the risk of HCC. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

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miR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects

Cited by 16 publications

References 41 publications

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility

Lack of Association of Two Common Polymorphisms rs2910164 and rs11614913 with Susceptibility to Hepatocellular Carcinoma: A Meta-Analysis

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