miR-19a and SOCS-1 expression in the differential diagnosis of laryngeal (glottic) verrucous squamous cell carcinoma

Marioni, Gino; Agostini, Marco; Cappellesso, Rocco; Bedin, Chiara; Ottaviano, Giancarlo; Marchese‐Ragona, Rosario; Lovato, Andrea; Cacco, Tommaso; Giacomelli, Luciano; Nitti, Donato; Blandamura, Stella; Stellini, Edoardo; Filippis, Cosimo de

doi:10.1136/jclinpath-2015-203308

Cited by 16 publications

(11 citation statements)

References 34 publications

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“…These results help to provide a potential novel prognostic marker and therapeutic target for ccRCC. A previous study demonstrated that miR-19a was aberrantly expressed in malignant glottic lesions (25) and several types of tumors, including lung (26) and gastric cancer (27). miR-19a was strongly associated with cancer invasion and metastasis, and poor prognosis of lung cancer patients (26).…”

Section: Discussionmentioning

confidence: 98%

miR-19a correlates with poor prognosis of clear cell renal cell carcinoma patients via promoting cell proliferation and suppressing PTEN/SMAD4 expression

Peng

Wang

et al. 2016

International Journal of Oncology

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MicroRNAs (miRNAs) were reported to be involved in the development of clear cell renal cell carcinoma (ccRCC). However, the study on miRNAs in ccRCC is far from complete. The present study identified miRNAs which could act as potential novel prognostic markers for ccRCC, and analyzed its possible mechanism. We found that miR-19a correlated with poor prognosis of ccRCC patients via promoting cell proliferation and suppressing PTEN/SMAD4 expression. Both the microarray screening result and TCGA KIRC dataset analysis showed that miR-19a was significantly upregulated in ccRCC tissues, and further analysis of TCGA data revealed that the upregulated level of miR-19a was strongly associated with advanced T stage and poor prognosis of ccRCC patients. Consistent with clinical observations, miR-19a overexpression significantly promoted ccRCC cell proliferation in vitro. To further explore the mechanism by which miR-19a correlated with cell proliferation and poor prognosis of ccRCC, we performed gene set enrichment analysis (GSEA) for target genes of miR-19a in ccRCC patients. Result indicated that the key target genes of miR-19a included SMAD4 and PTEN. In ccRCC tissues, expression levels of SMAD4 and PTEN were negatively correlated with expression level of miR-19a, revealing that miR-19a suppressed the expression of SMAD4 and PTEN in ccRCC patients. miR-19a overexpression significantly suppressed the expression of SMAD4 and PTEN in vitro, further verifying that SMAD4 and PTEN were the target genes of miR-19a in ccRCC cells. Our results elucidated the tumor promoting role of miR-19a and established miR-19a as a potential novel prognostic marker for ccRCC.

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Section: Discussionmentioning

confidence: 98%

miR-19a correlates with poor prognosis of clear cell renal cell carcinoma patients via promoting cell proliferation and suppressing PTEN/SMAD4 expression

Peng

Wang

et al. 2016

International Journal of Oncology

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“…Considering limited available data, it is still doubtful whether the results of immunohistochemistry performed on head and neck cancer biopsy material in the diagnostic phase can be used in clinical decision making; well-known head neck carcinoma heterogeneity [14] raises the concern that immunohistochemistry methods may not be accurate on small biopsy specimens. The very small size of the biopsy material is often a critical aspect in pathological diagnosis, in particular of laryngeal malignancies [15,16]. In addition, the pattern of expression may differ between the proteins.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of CD105- and CD31-Assessed Microvessel Density in Paired Biopsies and Surgical Samples of Laryngeal Carcinoma

Marioni

Franz

Ottaviano

et al. 2020

Cancers

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Small pretreatment laryngeal biopsies may not fully represent a tumor’s biological profile. This study on laryngeal squamous cell carcinoma (LSCC) aimed to investigate the prognostic role of CD105- and CD31-assessed microvessel density (MVD) in paired biopsies and surgical specimens and the association and discrepancy between CD105- and CD31-assessed MVD in biopsies and surgical specimens. CD105- and CD31-assessed MVD was analyzed in paired biopsies and surgical specimens of 45 consecutive cases of LSCC. In the LSCC biopsies and surgical specimens, median CD105-assessed MVD was significantly higher in N+ than in N0 cases (p = 0.0008, and p = 0.0002, respectively). Disease-free survival (DFS) was associated with CD105- and CD31-assessed MVD in both biopsies and surgical specimens (p < 0.0001 for all specimens). Multivariable Cox’s regression showed that pathological grade (p < 0.0001) and CD105-assessed MVD in LSCC biopsies (p = 0.0209) predicted DFS. Lin’s concordance coefficient showed that CD31 overestimated MVD compared with CD105 in LSCC biopsies and surgical specimens. CD105-assessed MVD should be further investigated in larger LSCC series as a potential prognostic marker for identifying: patients at higher risk of recurrence who might warrant more aggressive therapy; and cN0 patients requiring elective neck dissection for a significant risk of regional metastasis.

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“…miR19a: Marioni et al, recently, have demonstrated its higher expression in malignant glottis lesions than in benign conditions 16 . It was previously correlated with neck nodal metastasis, poor differentiation and advanced stage when overexpressed 17 .…”

Section: Discussionmentioning

confidence: 99%

A miRNA signature suggestive of nodal metastases from laryngeal carcinoma

Ricciardiello

Capasso

Kawasaki

et al. 2017

Acta Otorhinolaryngol Ital

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La scoperta che i microRNA sono frequentemente deregolati nei tumori consente di utilizzarli come marker prognostici e diagnostici. Lo scopo di questo studio multicentrico è stato stilare un profilo di espressione di miRNA specifico per il carcinoma della laringe. Lobiettivo secondario è stato identificare particolari miRNA deregolati da usare come potenziali biomarker predittivi di diffusione tumorale e di coinvolgimento linfonodale, nello specifico è stato ricercare un pattern di miRNA patognomonico per tessuto di carcinoma della laringe N+ e per N- rispettivamente. Gli Autori hanno identificato venti miRNA specifici per carcinoma della laringe ed inoltre una miRNA signature tessuto-specifica predittiva di metastasi linfonodali da carcinoma della laringe caratterizzata da 11 miRNA, sette dei quali over-espressi (up-regolati) e quattro down-regolati. Questi risultati permettono lidentificazione di un gruppo di potenziali biomarker tumore-specifici per il carcinoma della laringe che potrebbe essere usata per migliorare la sua diagnosi, in particolare negli stadi iniziali, e soprattutto per la sua prognosi.

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miR-19a and SOCS-1 expression in the differential diagnosis of laryngeal (glottic) verrucous squamous cell carcinoma

Abstract: Our preliminary outcomes suggest the utility of miR-19a in the challenging differential diagnosis of laryngeal VSCC. Although miR-19a has been found to regulate SOCS-1 expression, this evidence was not confirmed by this investigation.

Cited by 16 publications

References 34 publications

miR-19a correlates with poor prognosis of clear cell renal cell carcinoma patients via promoting cell proliferation and suppressing PTEN/SMAD4 expression

miR-19a correlates with poor prognosis of clear cell renal cell carcinoma patients via promoting cell proliferation and suppressing PTEN/SMAD4 expression

Prognostic Significance of CD105- and CD31-Assessed Microvessel Density in Paired Biopsies and Surgical Samples of Laryngeal Carcinoma

A miRNA signature suggestive of nodal metastases from laryngeal carcinoma

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