MiR-19b-1 inhibits angiogenesis by blocking cell cycle progression of endothelial cells

Upregulation of microRNA-17-92 cluster associates with tumor progression and prognosis in osteosarcoma

“…In the present study, we demonstrated a significant correlation between the miR-17-92 cluster level and the proliferation, invasion and migration of osteosarcoma cells: the expression of miR-17-92 cluster was higher in cells with higher proliferation, invasion and migration potential. The positive association of miR-17-92 cluster with cell proliferation, invasion and migration suggests that miR-17-92 cluster may be categorized as a "metastasis promotor gene" in osteosarcoma, which was in line with previous reports [22,33,34].…”

Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

“…MicroRNAs are now established therapeutically viable targets in the regulation of vascular inflammation and senescence (e.g., miR-146a, miR-217, miR-34a, miR-126, miR-21, miR-210, miR-181b) (121,151,169,170), tumor angiogenesis (miR-19b-1) (191), and in vascular diseases such as hypertension (miR-125a/b-5p) (83) and atherosclerosis (miR-92a, miR-27, miR-10a) (23, 46,47). In view of the established roles for TM in the regulation of inflammatory and thrombotic processes within the vascular wall, in conjunction with its indirect regulation by miR-92a via KLF2 (46,187), one can anticipate future studies detailing approaches to modulating TM levels in vivo using miRNA-targeting strategies.…”

Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review)

“…However, there is some support for down-regulation of miRNA-31 in gastric cancer, and urothelial cancers (85)(86)(87)(88). Moreover a comparison of miRNAs and mRNA profiles of primary and metastatic cancer lesions showed that miRNAs provided a more reliable and distinctive signature than mRNAs and found that miRNA signatures were superior to mRNAs in identifying the organ source of meta stases of unknown origin (74,89 (92). Finally, it is possible that cellular miRNAs can create better conditions for the growth of the tumor.…”