miR-203 promotes HaCaT cell overproliferation through targeting LXR-α and PPAR-γ

Xiao, Yueyuan; Wang, Haizhen; Wang, Chang; Zeng, Bijun; Tang, Xueyong; Zhang, Yujin; Peng, Youhua; Luo, Meijunzi; Huang, Pan; Yang, Zhibo

doi:10.1080/15384101.2020.1783934

Cited by 25 publications

(20 citation statements)

References 40 publications

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“…Suppressor of cytokine signaling 3 (SOCS-3), the first reported target gene of miR-203, has also been identified to regulate keratinocyte proliferation and differentiation (10). Moreover, a recent study (25) has shown that liver X receptor-α (LXR-α) and peroxisome proliferator-activated receptor-γ (PPAR-γ) are remarkably downregulated in psoriatic lesions, and the overexpression of each gene is sufficient to inhibit keratinocyte proliferation. miR-203 negatively regulates the expression of LXR-α/PPAR-γ by directly targeting 3 ′ UTRs of their mRNAs, suggesting that the miR-203-LXR-α /PPARγ axis is crucially involved in the hyperproliferative phenotype of psoriatic keratinocytes and may provide drug targets for psoriasis treatment.…”

Section: Mir-203mentioning

confidence: 99%

miRNAs Flowing Up and Down: The Concerto of Psoriasis

Yang

Wang

2021

Front. Med.

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Psoriasis is a chronic immune-mediated skin disease, whose hallmarks include keratinocyte hyperproliferation and CD4+ T cell subsets imbalance. Dysregulated microRNAs (miRNAs) identified in psoriasis have been shown to affect keratinocyte and T cell functions, with studies on the molecular mechanisms and intrinsic relationships of the miRNAs on the way. Here, we focus on the dysregulated miRNAs that contribute to the two hallmarks of psoriasis with the miRNA target genes confirmed. We review a network, in which, upregulated miR-31/miR-203/miR-155/miR-21 and downregulated miR-99a/miR-125b facilitate the excessive proliferation and abnormal differentiation of psoriatic keratinocytes; upregulated miR-210 and downregulated miR-138 work in concert to distort CD4+ T cell subsets balance in psoriasis. The miRNAs exert their functions through regulating key psoriasis-associated transcription factors including NF-κB and STAT3. Whether flowing up or down, these miRNAs collaborate to promote the development and maintenance of psoriasis.

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Section: Mir-203mentioning

confidence: 99%

miRNAs Flowing Up and Down: The Concerto of Psoriasis

Yang

Wang

2021

Front. Med.

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“…Moreover, in vitro experiments showed that miR-203 expression is upregulated after IL-17 stimulation in HaCat cells and that miR-203 is involved in the activation of the JAK2/STAT3 signalling pathway, which contributes to VEGF secretion and the perpetuation of pathological angiogenesis [ 19 ]. Recently, it has been described that miR-203 negatively regulates keratinocyte proliferation through the direct targeting of NR1H3 and PPARG [ 22 ]. Therefore, in psoriasis, the data suggest that miR-203 may be involved in skin epidermal hyperplasia, inflammation and angiogenesis ( Figure 2 ).…”

Section: Role Of Mirnas In the Skin Pathogenesis Of Cutaneous Immumentioning

confidence: 99%

MicroRNAs in Several Cutaneous Autoimmune Diseases: Psoriasis, Cutaneous Lupus Erythematosus and Atopic Dermatitis

Domingo

Solé

Moliné

et al. 2020

Cells

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MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that regulate the gene expression at a post-transcriptional level and participate in maintaining the correct cell homeostasis and functioning. Different specific profiles have been identified in lesional skin from autoimmune cutaneous diseases, and their deregulation cause aberrant control of biological pathways, contributing to pathogenic conditions. Detailed knowledge of microRNA-affected pathways is of crucial importance for understating their role in skin autoimmune diseases. They may be promising therapeutic targets with novel clinical implications. They are not only present in skin tissue, but they have also been found in other biological fluids, such as serum, plasma and urine from patients, and therefore, they are potential biomarkers for the diagnosis, prognosis and response to treatment. In this review, we discuss the current understanding of the role of described miRNAs in several cutaneous autoimmune diseases: psoriasis (Ps, 33 miRNAs), cutaneous lupus erythematosus (CLE, 2 miRNAs) and atopic dermatitis (AD, 8 miRNAs). We highlight their role as crucial elements implicated in disease pathogenesis and their applicability as biomarkers and as a novel therapeutic approach in the management of skin inflammatory diseases.

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“…Psoriasis, an immune-mediated chronic in ammatory skin disease, is featured with epidermal hyperplasia, angiogenesis, and in ammatory cell in ltration (15,16). It is a key psoriasis treatment to inhibit these cellars events.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of miR-106a-5p in patients with psoriasis and its regulatory role in inflammatory responses

Miao

Tong

et al. 2020

Preprint

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Background: Psoriasis is a multifactorial, recurring, and chronic inflammatory skin disease. This study was designed to explore the potential role of microRNA-106a-5p (miR-106a-5p) in psoriasis.Methods: The expression levels of miR-106a-5p in the serum of psoriasis patients and healthy individuals were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic value of miR-106a-5p in serum was evaluated by the receiver operating characteristics curve (ROC). The levels of interleukin-22 (IL-22), interleukin-17A (IL-17A), and tumor necrosis factor-alpha (TNF-alpha) were determined by enzyme-linked immunosorbent assay.Results: The serum expression of miR-106a-5p was found to be up-regulated in psoriasis patients. ROC curve showed that miR-106a-5p had high specificity and sensitivity in the diagnosis of psoriasis. The correlation between the serum expression level of miR-106a-5p and PASI was positive. The relative expression levels of IL-17A, IL-22 and TNF-alpha in serum of psoriasis patients were significantly upregulated compared with that in healthy control, and showed positive association with serum miR-106a-5p levels. Cell experiments demonstrated that upregulation of miR-106a-5p could promote cell proliferation, and the levels of IL-22, IL-17A and TNF-alpha were upregulated significantly in M5-induced HaCaT cells.Conclusion: Considering the novel and vital role in psoriasis progression, miR-106a-5p is expected to be a new potent target for treatment of psoriasis. MiR-106-5p was expected to use for more immunity diseases research and therapy.

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miR-203 promotes HaCaT cell overproliferation through targeting LXR-α and PPAR-γ

Cited by 25 publications

References 40 publications

miRNAs Flowing Up and Down: The Concerto of Psoriasis

miRNAs Flowing Up and Down: The Concerto of Psoriasis

MicroRNAs in Several Cutaneous Autoimmune Diseases: Psoriasis, Cutaneous Lupus Erythematosus and Atopic Dermatitis

Diagnostic value of miR-106a-5p in patients with psoriasis and its regulatory role in inflammatory responses

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