miR-21 ablation and obeticholic acid ameliorate NASH in mice

Rodrigues, P.M.; Afonso, Marta B.; Simão, André L.; Carvalho, Catarina; Trindade, Alexandre; Duarte, Antonio Moral; Borralho, Pedro M.; Machado, Mariana Verdelho; Cortez‐Pinto, Helena; Rodrigues, C.M.P.; Castro, Rui E.

doi:10.1016/s0168-8278(17)31639-2

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“…miR-21 is hypothesized to regulate the genes in hepatic cholesterol and triglyceride metabolisms ( 17 ). Furthermore, ablation of hepatic miR-21 was shown to decrease hepatic inflammation and improve fibrosis ( 18 ). In our study, we showed that serum miR-21 and -22 were both positively correlated with IHTG, TG, and LDL-C only in the NAFLD group.…”

Section: Discussionmentioning

confidence: 99%

Circulating microRNAs Are Associated With Metabolic Markers in Adolescents With Hepatosteatosis

Lin

Mercer

et al. 2022

Front. Endocrinol.

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BackgroundAltered hepatic microRNA (miRNA) expression may play a role in the development of insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). Circulating miRNAs could mirror the liver metabolism.ObjectiveThis study aimed to assess the relationship between serum miRNA profile in children with obesity, IR, and NAFLD.MethodsAdolescents with obesity (n = 31) were stratified based on insulin resistance and NAFLD status. One-hundred seventy-nine miRNAs were determined in the serum by quantitative RT-PCR. Differentially expressed miRNAs were compared between groups, and log-transformed levels correlated with metabolic markers and intrahepatic triglyceride.ResultsSerum miR-21-5p, -22-3p, -150-5p, and -155-5p levels were higher in children with IR and NAFLD, and their expression levels correlated with hepatic fat and serum triglyceride. In patients with NAFLD, miR-155-5p correlated with ALT (r = 0.68, p<0.01) and AST (r = 0.64, p<0.01) and miR-21-5p and -22-3p levels correlated with plasma adiponectin (r = -0.71 and r = -0.75, respectively, p<0.05) and fibroblast growth factor-21 (r = -0.73 and r = -0.89, respectively, p<0.01). miR-27-3a level was higher in children without IR and NAFLD.ConclusionsSeveral miRNAs are differentially expressed in children with IR and NAFLD. Determining their mechanistic roles may provide newer diagnostic tools and therapeutic targets for pediatric NAFLD.

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Section: Discussionmentioning

confidence: 99%