miR-21 predicts poor prognosis in patients with osteosarcoma

Ren, Xianfeng; Shen, Yuqin; Liu, Jianyong; Jiang, Xin

doi:10.1080/09674845.2016.1220710

Cited by 40 publications

(25 citation statements)

References 27 publications

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“…There were 4 studies assessing miR-21 as a predictor of survival in osteosarcoma using multivariate analysis, among which 3 used tumor tissues ( n = 153) [ 5 , 54 , 61 ] and 1 used serum samples ( n = 65) [ 53 ] (Table 3 ). Once pooled, studies with different baselines showed obvious statistical heterogeneity.…”

Section: Resultsmentioning

confidence: 99%

MicroRNAs with prognostic significance in osteosarcoma: a systemic review and meta-analysis

et al. 2017

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IntroductionThis study aimed to elucidate the prognostic value of microRNAs (miRNAs) in patients with osteosarcoma.Materials and MethodsStudies were recruited by searching PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang data-bases (final search update conducted January 2017). Eligible studies were identified and the quality was assessed using multiple search strategies.ResultsA total of 55 articles that investigated the correlation between miRNA expression and either patient survival or disease recurrence in osteosarcoma was initially identified. Among these, 30 studies were included in the meta-analysis. The results of our meta-analysis revealed that elevated levels of miR-21, miR-214, miR-29, miR-9 and miR-148a were associated with poor prognosis in osteosarcoma. Additionally, downregulated miR-382, miR26a, miR-126, miR-195 and miR-124 expression indicated poor prognosis in osteosarcoma.ConclusionsmiRNAs may act as independent prognostic factors in patients with osteosarcoma and are useful in stratifying risk.

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Section: Resultsmentioning

confidence: 99%

MicroRNAs with prognostic significance in osteosarcoma: a systemic review and meta-analysis

et al. 2017

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“…Aberrantly expressed miRs are implicated in the regulation of OS onset and development (23)(24)(25). Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

Guang-hong

Jiang

2018

Mol Med Report

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Aberrantly expressed microRNAs (miRs) are implicated in the regulation of osteosarcoma (OS) onset and development. Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS. In the present study, reverse transcription‑quantitative polymerase chain reaction analysis revealed that miR‑376a‑3p expression was downregulated in OS tissues and cell lines. Additionally, decreased miR‑376a expression was associated with tumor size and lymph node infiltration. Restoration of miR‑376a expression reduced cell proliferation and invasion of OS. Furthermore, special AT‑rich sequence‑binding protein 1 (SATB1) was identified as a direct target gene of miR‑376a in OS cells. Furthermore, SATB1 was overexpressed in OS tissues and SATB1 overexpression was inversely correlated with the expression level of miR‑376a. In addition, ectopic SATB1 expression counteracted the inhibitory effects of miR‑376a overexpression on the proliferation and invasion of OS cells. All these results identified that reduced miR‑376a expression may be implicated in the mechanism underlying OS progression, suggesting that the miR‑376a/SATB1 axis may be a promising novel target for potential therapeutic methods for the effective treatment of patients with OS.

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“…In particular, miR21 (Fig. 2) emerges consistently as a significant marker for poor prognosis, when its expression levels in the plasma of patients with OS and cancer cells are compared with those found in controls (62)(63)(64). miR-199a, which has been shown to be dysregulated in several types of tumor, has been found to be underexpressed in osteosarcoma cells and patient samples.…”

Section: Role Of Mirnas In the Pathological Osteogenic Commitment Of mentioning

confidence: 95%

Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review)

2018

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MicroRNAs (miRNAs) are considered 'micro- managers of gene expression' and awareness of their fundamental role in the control of biological functions is constantly increasing. Bone formation and homeostasis are complex processes involving the differentiation and interaction of various cell types. Several miRNAs have been shown to be involved in different pathways and stages in the regulation of normal and abnormal bone formation and turnover. This present review focuses on the involvement of miRNAs in terms of their effect on the commitment of bone marrow mesenchymal stem cells towards osteogenesis, adipogenesis and chondrogenesis, respectively. The miRNAs involved in regulating osteoblast, chondroblast and osteoclast activity, are also taken into consideration, as are their interactions. miRNA expression levels, which may differ significantly in healthy versus pathological conditions, can be readily monitored and represent useful biomarkers. Several studies have suggested that miRNAs offer potential as useful biomarkers of bone pathologies, including osteoporosis and osteosarcoma. The development of efficient methods of delivering miRNA mimics or miRNA inhibitors into specific cells remains a challenge for novel therapeutic applications in the field of personalized medicine.

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miR-21 predicts poor prognosis in patients with osteosarcoma

Abstract: Upregulation of miR-21 was associated with poor clinicopathological characteristics. It is used as a marker of poor prognosis in patients with osteosarcoma.

Cited by 40 publications

References 27 publications

MicroRNAs with prognostic significance in osteosarcoma: a systemic review and meta-analysis

MicroRNAs with prognostic significance in osteosarcoma: a systemic review and meta-analysis

MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

Role of microRNAs in progenitor cell commitment and osteogenic differentiation in health and disease (Review)

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