miR-211 inhibits proliferation, invasion and migration of cervical cancer via targeting SPARC

Qu, Xuqin; Gao, Dezhen; Ren, Qingxia; Jiang, Xiufang; Bai, Jianhua; Li, Sheng

doi:10.3892/ol.2018.8735

Cited by 21 publications

(19 citation statements)

References 29 publications

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“…SIP1 is accepted as a strong suppressor of E-cadherin and is known to inhibit kinds of junctional complex genes, thus activating invasion and metastasis. miR-211 appears to be anti-miRNA due to its suppressive effect on Mucin 4 (MUC4) [ 131 ] and protein acidic and rich in cysteine (SPARC) [ 132 ], thus inhibiting CC cell invasion and reversing EMT properties. SPARC, which belongs to the matricellular family of secreted proteins, is related to cell matrix interactions and affects cell progression and might serve as an important factor in the EMT of CC.…”

Section: The Role Of Emt-related Mirnas In the Metastasis Of CCmentioning

confidence: 99%

The role of miRNAs in the invasion and metastasis of cervical cancer

Wang

Chen

2019

Bioscience Reports

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Cervical cancer (CC) with early metastasis of the primary tumor results in poor prognosis and poor therapeutic outcomes. MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a substantial role in regulating gene expression post-transcriptionally and influence the development and progression of tumors. Numerous studies have discovered that miRNAs play significant roles in the invasion and metastasis of CC by affecting specific pathways, including Notch, Wnt/β-catenin, and phosphoinositide-3 kinase (PI3K)-Akt pathways. miRNAs also effectively modulate the process of epithelial–mesenchymal transition. Many studies provide new insights into the role of miRNAs and the pathogenesis of metastatic CC. In this review, we will offer an overview and update of our present understanding of the potential roles of miRNAs in metastatic CC.

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Section: The Role Of Emt-related Mirnas In the Metastasis Of CCmentioning

confidence: 99%

The role of miRNAs in the invasion and metastasis of cervical cancer

Wang

Chen

2019

Bioscience Reports

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“…Through directly binding to the complementary sequences in the 3ʹ-untranslated regions (3ʹ-UTRs) of their target mRNAs and leading to the target mRNA degradation and/or translation suppression, miRNAs are deemed as crucial regulators of gene expression and highly implicated in tumorigenesis, including in CC development. [6][7][8] Numerous miRNAs have been identified as oncogenes or tumor suppressors in CC, such as miR-338-3p, 9 miR-211 10 and miR-877. 11 Besides, some miRNAs have been reported to be abnormally expressed and have potential diagnostic or prognostic significance in clinic.…”

Section: Introductionmentioning

confidence: 99%

<p>MiR-1193 Inhibits the Malignancy of Cervical Cancer Cells by Targeting Claudin 7 (CLDN7)</p>

Zhang

Lin

Bao

et al. 2020

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Objective: MicroRNAs (miRNAs) are highly involved in cancer development, including in cervical cancer (CC). In this study, we aimed to investigate the role and possible mechanism of a poorly studied miRNA, miR-1193, in CC progression. Materials and Methods: Expression of miR-1193 was determined in 60 pairs of cervical samples. The impacts of miR-1193 on CC cell proliferation, invasion and migration capacities were verified by CCK-8, transwell and wound healing assays, respectively. Then, bioinformatics prediction, luciferase reporter assay, qRT-PCR and Western blot were successively conducted to study the targeting of claudin 7 (CLDN7) by miR-1193. After CLDN7 was restored in miR-1193-overexpressed cells, the rescue effects were determined. Finally, CLDN7 expression was analyzed in cervical samples, and its expression correlation with miR-1193 was explored. Results: Compared with paired normal tissues, miR-1193 was sharply decreased in abnormal tissues (intraepithelial lesions and cancerous tissues). Especially, miR-1193 expression was gradually decreased in low-grade squamous intraepithelial lesions, high-grade squamous intraepithelial lesions and CC. Enforced expression of miR-1193 inhibited CC cell proliferation, invasion and migration. Mechanistically, we confirmed CLDN7 as a target of miR-1193, and restoration of CLDN7 robustly rescued the tumor suppressing effects of miR-1193 in CC cells. CLDN7 was upregulated in abnormal cervical tissues and its expression exhibited inverse correlation with that of miR-1193 in CC. Conclusion: Our results suggested that miR-1193 exerted tumor inhibitory roles in CC malignancy by directly targeting CLDN7.

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“…We also reported that the artificial over-expression of MIR211 in amelanotic melanoma cells (A375) increases mitochondrial respiration by inhibiting Pyruvate Dehydrogenase Kinase 4 ( PDK4 ) mRNA levels, which was associated with reduced cell survival and lessened invasive properties under cell culture conditions ( 13 ). Consistently, miRNA profiling studies revealed that MIR211 expression is down-regulated not only in melanoma ( 12 , 54 ), but also in other cancers such as glioma ( 73 ) and glioblastoma ( 38 ), prostate cancer ( 74 ), hepatocellular carcinoma ( 48 ), epithelial ovarian cancer ( 45 ), cervical cancer ( 16 , 56 ), and breast cancer ( 75 ). These foregoing results together point towards a general tumor-suppressor role of MIR211 .…”

Section: Cellular And/or Genetic Contexts Determine the Effects Of MImentioning

confidence: 86%

“…Secreted protein acidic and rich in cysteine (SPARC) is a matricellular family of proteins, which modulates cell-matrix interactions and tissue remodeling and, thereby, EMT. In cervical cancer, MIR211 directly targets SPARC and thus acts as a tumor suppressor gene ( 16 ). MIR211 regulates Matrix metalloproteinase-9 (MMP-9) and thereby reduces EMT in gastric cancer ( 58 ).…”

Section: Broadly Pleiotropic Tumor Suppressor and Oncogenic Behavior mentioning

confidence: 99%

The Paradoxical Behavior of microRNA-211 in Melanomas and Other Human Cancers

2021

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Cancer initiation, progression, and metastasis leverage many regulatory agents, such as signaling molecules, transcription factors, and regulatory RNA molecules. Among these, regulatory non-coding RNAs have emerged as molecules that control multiple cancer types and their pathologic properties. The human microRNA-211 (MIR211) is one such molecule, which affects several cancer types, including melanoma, glioblastoma, lung adenocarcinomas, breast, ovarian, prostate, and colorectal carcinoma. Previous studies suggested that in certain tumors MIR211 acts as a tumor suppressor while in others it behaves as an oncogenic regulator. Here we summarize the known molecular genetic mechanisms that regulate MIR211 gene expression and molecular pathways that are in turn controlled by MIR211 itself. We discuss how cellular and epigenetic contexts modulate the biological effects of MIR211, which exhibit pleiotropic effects. For example, up-regulation of MIR211 expression down-regulates Warburg effect in melanoma tumor cells associated with an inhibition of the growth of human melanoma cells in vitro, and yet these conditions robustly increase tumor growth in xenografted mice. Signaling through the DUSP6-ERK5 pathway is modulated by MIR211 in BRAFV600E driven melanoma tumors, and this function is involved in the resistance of tumor cells to the BRAF inhibitor, Vemurafenib. We discuss several alternate but testable models, involving stochastic cell-to-cell expression heterogeneity due to multiple equilibria involving feedback circuits, intracellular communication, and genetic variation at miRNA target sties, to reconcile the paradoxical effects of MIR211 on tumorigenesis. Understanding the precise role of this miRNA is crucial to understanding the genetic basis of melanoma as well as the other cancer types where this regulatory molecule has important influences. We hope this review will inspire novel directions in this field.

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miR-211 inhibits proliferation, invasion and migration of cervical cancer via targeting SPARC

Cited by 21 publications

References 29 publications

The role of miRNAs in the invasion and metastasis of cervical cancer

The role of miRNAs in the invasion and metastasis of cervical cancer

<p>MiR-1193 Inhibits the Malignancy of Cervical Cancer Cells by Targeting Claudin 7 (CLDN7)</p>

The Paradoxical Behavior of microRNA-211 in Melanomas and Other Human Cancers

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