2012
DOI: 10.1016/j.bbrc.2012.10.039
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MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin

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Cited by 90 publications
(78 citation statements)
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“…miRNAs have emerged as critical regulators of HCC progression and tumorigenesis (19,20). In the present study, RT-qPCR was performed to measure miR-138 expression in HCC tissues and cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…miRNAs have emerged as critical regulators of HCC progression and tumorigenesis (19,20). In the present study, RT-qPCR was performed to measure miR-138 expression in HCC tissues and cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…miR-214 inhibits cell growth in hepatocellular carcinoma (HCC) through suppression of β-catenin (34). In addition, miR-214 results in the suppression of cyclin d1, a downstream gene of the Wnt-β-catenin pathway (34).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, miR-214 results in the suppression of cyclin d1, a downstream gene of the Wnt-β-catenin pathway (34). Since cyclin d1 is also a target of miR-34a in HCC (35), the upregulation of miR-34a reduces cyclin D1 expression (36).…”
Section: Discussionmentioning
confidence: 99%
“…This characteristic of miRNAs is an advantage for cancer therapy since tumors display specific signaling pathway alterations that can be controlled by single miRNAs 11, 12. Many miRNAs have been reported to target beta‐catenin: mature miRNA (miR)‐200a in human meningioma,16 members of the miR‐34 family in lung and breast carcinomas,17 miR‐483‐3p in breast and colon cancers,18 and miR‐214 in HCC 19. However, it is unknown if one of these miRNAs targets beta‐catenin in HBL.…”
Section: Introductionmentioning
confidence: 99%