MiR‐26 controls LXR‐dependent cholesterol efflux by targeting ABCA1 and ARL7

Sun, Dongsheng; Zhang, Jun; Xie, Jianhong; Wei, Wei; Chen, Mantao; Zhao, Xiang

doi:10.1016/j.febslet.2012.03.068

Cited by 120 publications

(93 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…57 It has been reported that the miR-26 family are involved in human adipogenesis. 49 , 22 More importantly, the miR-26a/b are expressed concomitantly with their host genes in GMEC. Our data revealed a functional significance between miR-26a/b and the CTDSP family in the regulation of lipid metabolism in GMEC, which is consistent with the effect on human adipogenesis 22 , 48 and in cell cycle control.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting theINSIG1gene

et al. 2016

View full text Add to dashboard Cite

The microRNA-26 (miR-26) family is known to control adipogenesis in non-ruminants. The genomic loci of miR-26a and miR-26b have been localized in the introns of genes encoding for the proteins of the Cterminal domain RNA polymerase II polypeptide A small phosphatase (CTDSP) family. Insulin-induced gene 1 (INSIG1) encodes a protein with a key role in the regulation of lipogenesis in rodent liver. In the present study, we investigated the synergistic function of the miR-26 family and their host genes in goat mammary epithelial cells (GMEC). Downregulation of miR-26a/b and their host genes in GMEC decreased the expression of genes relate to fatty acid synthesis (PPARG, LXRA, SREBF1, FASN, ACACA, GPAM, LPIN1, DGAT1 and SCD1), triacylglycerol accumulation and unsaturated fatty acid synthesis. Luciferase reporter assays confirmed INSIG1 as a direct target of miR-26a/b. Furthermore, inhibition of the CTDSP family also downregulated the expression of INSIG1. Taken together, our findings highlight a functional association of miR-26a/b, their host genes and INSIG1, and provide new insights into the regulatory network controlling milk fat synthesis in GMEC. The data indicate that targeting this network via nutrition might be important for regulating milk fat synthesis in ruminants.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting theINSIG1gene

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In addition, other miRNAs, including miR-33 (Rayner et al, 2011), miR-785 (Ramirez et al, 2011), miR-106b and miR-26 (Kim et al, 2012Sun et al, 2012), have also been shown to regulate the expression of ABCA1, and whether there are interactions between LXRs and these miRNAs remains to be determined.…”

Section: ! 53mentioning

confidence: 99%

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases

Ma¹,

Deng²,

Hu³

et al. 2017

Current Issues in Molecular Biology

View full text Add to dashboard Cite

Liver X receptors α (LXRα) and β (LXRβ) are essential for protection against cardiovascular diseases. LXRs are members of the nuclear receptor superfamily of DNA-binding transcription factors and act as sensors of cholesterol homeostasis. In this review, we introduce LXRs and briefly describe the roles of LXRs in reverse cholesterol transport and trans-intestinal cholesterol efflux. We discuss LXR agonists and the downstream genes of LXRs that are involved in the regulation of cholesterol transport. In addition, we describe the cardioprotective effects of LXRs against atherosclerosis, myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, and myocardial hypertrophy. Finally, we expand our discussion to the actions of LXRs in atherosclerosis and suggest several potential research avenues that may be of interest to clinicians and basic scientists. The information included herein may be useful for the design of future experimental research studies and may advance the investigation of LXRs as therapeutic targets.

show abstract

“…70 Another aspect of the posttranscriptional regulation of ABCA1 comes from a recent report showing that the ATP-binding cassette transporter, ABCA12, increases ABCA1 stability and enhances macrophage cholesterol efflux in a liver X receptor-β-dependent manner.…”

mentioning

confidence: 99%

Regulation of High-Density Lipoprotein Metabolism

Rye

Barter

2014

Circulation Research

100

View full text Add to dashboard Cite

There is compelling evidence from human population studies that plasma levels of high-density lipoprotein (HDL) cholesterol correlate inversely with cardiovascular risk. Identification of this relationship has stimulated research designed to understand how HDL metabolism is regulated. The ultimate goal of these studies has been to develop HDL-raising therapies that have the potential to decrease the morbidity and mortality associated with atherosclerotic cardiovascular disease. However, the situation has turned out to be much more complex than originally envisaged. This is partly because the HDL fraction consists of multiple subpopulations of particles that vary in terms of shape, size, composition, and surface charge, as well as in their potential cardioprotective properties. This heterogeneity is a consequence of the continual remodeling and interconversion of HDL subpopulations by multiple plasma factors. Evidence that the remodeling of HDLs may impact on their cardioprotective properties is beginning to emerge. This serves to highlight the importance of understanding not only how the remodeling and interconversion of HDL subpopulations is regulated but also how these processes are affected by agents that increase HDL levels. This review provides an overview of what is currently understood about HDL metabolism and how the subpopulation distribution of these lipoproteins is regulated.

show abstract

MiR‐26 controls LXR‐dependent cholesterol efflux by targeting ABCA1 and ARL7

Cited by 120 publications

References 44 publications

MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting theINSIG1gene

MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting theINSIG1gene

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases

Regulation of High-Density Lipoprotein Metabolism

Contact Info

Product

Resources

About