miR‐29c‐3p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models

Wang, Ruili; Yao, Jie; Gong, Fuhua; Chen, Songsheng; He, Yongqing; Hu, Chun-Ting; Li, Chen

doi:10.1111/gtc.12877

Cited by 12 publications

(6 citation statements)

References 54 publications

(72 reference statements)

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“…Moreover, miR-29c-3p has been demonstrated to repress microglial NLRP3 inflammasome activation and neuronal apoptosis in Pd models (80). Further mechanistic evaluation has indicated that upregulation of miR-29c-3p inhibits autophagy by decreasing the expression of ten-eleven translocation 2, thus alleviating MPTP-mediated loss of dopaminergic neurons in SN (81).…”

Section: Roles Of Autophagy-regulating Mirnas In Pdmentioning

confidence: 99%

Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)

Ma¹,

Liang²,

Hu³

et al. 2023

Int J Mol Med

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Parkinson's disease (Pd) is a neurodegenerative disorder that has a high incidence during the aging process and is characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunctions and non-motor symptoms. Impaired clearance and excessive accumulation of aberrantly modified proteins or damaged organelles, such as aggregated α-synuclein and dysfunctional mitochondria, are regarded as the main causes of nigrostriatal neurodegeneration. As one of the major degradation pathways, autophagy can recycle these useless or toxic substances to maintain cellular homeostasis and it plays a crucial role in Pd progression. MicroRNAs (miRNAs) are a group of small non-coding RNA molecules that regulate gene expression by silencing targeted mRNAs. Recent studies have illustrated that autophagy-regulating miRNA has been implicated in pathological processes of Pd, including α-synuclein accumulation, mitochondrial damage, neuroinflammation and neuronal apoptosis, which suggests that targeting autophagy-regulating miRNAs may provide novel therapeutic strategies for this disease. The present review summarizes the role of autophagy in Pd and emphasizes the role of miRNA-mediated autophagy in Pd, for the development of promising interventions in this disease.

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Section: Roles Of Autophagy-regulating Mirnas In Pdmentioning

confidence: 99%

Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)

Ma¹,

Liang²,

Hu³

et al. 2023

Int J Mol Med

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“…Overall, over-expression of miR-29c-3p in PD models reduces autophagy, which may be caused by TET2. The findings exhibited the role of miR-29c-3p in controlling autophagy to accelerate the progression of PD (Wang R. et al, 2021). One of the studies sought to understand the targeting of X-box binding protein 1 (XBP1) by miR-326 in the biological functions of PD.…”

Section: Micrornas and Autophagy Mediating Pathways In Parkinson's Di...mentioning

confidence: 99%

MicroRNAs in the epigenetic regulation of disease progression in Parkinson’s disease

Selvakumar

Preethi

Tusubira

et al. 2022

Front. Cell. Neurosci.

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Parkinson’s disease (PD) is a multifactorial neurodegenerative condition with symptoms such as resting tremor, rigidity, bradykinesia (slowness of moment), and postural instability. Neuroinflammation plays a significant part in the onset and progression of neurodegeneration in a wide range of disorders, including PD. The loss of dopaminergic neurons in the substantia nigra (SN) is thought to be the primary cause of PD disease progression. However, other neurotransmitter systems like serotoninergic, glutamatergic, noradrenergic, adrenergic, cholinergic, tryptaminergic, and peptidergic appear to be affected as well. Epigenetic regulation of gene expression is emerging as an influencing factor in the pathophysiology of PD. In recent years, epigenetic regulation by microRNAs (miRNAs) has been discovered to play an important function in the disease progression of PD. This review explores the role of miRNAs and their signaling pathways in regulating gene expression from development through neurodegeneration and how these mechanisms are linked to the pathophysiology of PD, emphasizing potential therapeutic interventions.

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“…As a result, this alleviates the degeneration of DopNs in the SN caused by MPTP. 105,106 Neuroprotective miRNAs are reduced in different animal and cellular forms of PD. Increasing the amount of these miRNAs may mitigate α-syn pathology, neuroinflammation, neuronal OS, and CD.…”

Section: Mirnasmentioning

confidence: 99%

“…Additional mechanistic analysis has shown that the increase in miR‐29c‐3p suppresses autophagy by reducing the levels of 10–11 translocation 2. As a result, this alleviates the degeneration of DopNs in the SN caused by MPTP 105,106 …”

Section: Ncrnas As Regulators Of Autophagy In Pdmentioning

confidence: 99%

Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

Hussain,

Moglad,

Afzal

et al. 2024

CNS Neurosci Ther

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BackgroundParkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence suggests a significant role for disrupted autophagy—a crucial cellular process for maintaining protein and organelle integrity.MethodsThis review focuses on the role of non‐coding RNAs (ncRNAs) in modulating autophagy in PD. We conducted a comprehensive review of recent studies to explore how ncRNAs influence autophagy and contribute to PD pathophysiology. Special attention was given to the examination of ncRNAs' regulatory impacts in various PD models and patient samples.ResultsFindings reveal that ncRNAs are pivotal in regulating key processes associated with PD progression, including autophagy, α‐synuclein aggregation, mitochondrial dysfunction, and neuroinflammation. Dysregulation of specific ncRNAs appears to be closely linked to these pathogenic processes.ConclusionncRNAs hold significant therapeutic potential for addressing autophagy‐related mechanisms in PD. The review highlights innovative therapeutic strategies targeting autophagy‐related ncRNAs and discusses the challenges and prospective directions for developing ncRNA‐based therapies in clinical practice. The insights from this study underline the importance of ncRNAs in the molecular landscape of PD and their potential in novel treatment approaches.

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miR‐29c‐3p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models

Cited by 12 publications

References 54 publications

Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)

Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)

MicroRNAs in the epigenetic regulation of disease progression in Parkinson’s disease

Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

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