miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8

Qiu, Haitao; Shen, Xiaokang; Chen, Bing; Chen, YangQuan; Feng, Guodong; Chen, Shilin; Feng, Dan; Xu, Qiaoshu

doi:10.1007/s10495-021-01665-1

Cited by 23 publications

(19 citation statements)

References 43 publications

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“…In particular, LRP8 level was markedly increased in lung cancer tissues compared with the control group, apparently acting as an oncogene. In addition, miR-30b-5p inhibits lung cancer cell viability, migration and invasion and enhances cell sensitivity to cysplatin via targeting LRP8, suggesting that miR-30b-5p inhibits lung cancer progression by targeting LRP8 [ 147 ]. Lu et al, published a similar work highlighting the role of miR-142 as a gastric cancer suppressor by targeting LRP8 [ 144 ].…”

Section: Apolipoprotein E Receptor 2 (Lrp8)mentioning

confidence: 99%

Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration

Passarella

Ciampi

Liberto

et al. 2022

IJMS

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The low-density-lipoprotein receptors represent a family of pleiotropic cell surface receptors involved in lipid homeostasis, cell migration, proliferation and differentiation. The family shares common structural features but also has significant differences mainly due to tissue-specific interactors and to peculiar proteolytic processing. Among the receptors in the family, recent studies place low-density lipoprotein receptor-related protein 8 (LRP8) at the center of both neurodegenerative and cancer-related pathways. From one side, its overexpression has been highlighted in many types of cancer including breast, gastric, prostate, lung and melanoma; from the other side, LRP8 has a potential role in neurodegeneration as apolipoprotein E (ApoE) and reelin receptor, which are, respectively, the major risk factor for developing Alzheimer’s disease (AD) and the main driver of neuronal migration, and as a γ-secretase substrate, the main enzyme responsible for amyloid formation in AD. The present review analyzes the contributions of LDL receptors, specifically of LRP8, in both cancer and neurodegeneration, pointing out that depending on various interactions and peculiar processing, the receptor can contribute to both proliferative and neurodegenerative processes.

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Section: Apolipoprotein E Receptor 2 (Lrp8)mentioning

confidence: 99%

Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration

Passarella

Ciampi

Liberto

et al. 2022

IJMS

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“…MiR-30b-5p inhibits the migration and invasion of esophageal cancer by targeting ITGA5 and PDGFRb [ 48 ]. In addition, the miR-30b-5p inhibits lung cancer progression and enhances cisplatin sensitivity by targeting LRP8 [ 13 ]. This study shows that miR-30b-5p can significantly inhibit the proliferation, migration, and invasion of PTC cells while promoting the apoptosis of PTC cells.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the miR-30b-5p is reported as a new diagnostic marker to improve the diagnosis of PTC [11]. MiR-30b-5p often acts as a tumor suppressor, inhibiting the proliferation and metastasis of cancer, including renal cell carcinoma [12], lung cancer [13], and colorectal cancer [14]. In terms of mechanism, miR-30b-5p is reported to control tumor or disease progression by regulating autophagy [15][16][17][18], epithelial-mesenchymal transition (EMT) [12,19], and mTOR signaling pathway [20].…”

mentioning

confidence: 99%

miR-30b-5p inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting GALNT7 via the EGFR/PI3K/AKT pathway

Wang

Zhao

et al. 2021

Cancer Cell Int

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Background Papillary thyroid carcinoma (PTC) is a common endocrine tumor. Increasing evidence has shown that microRNA dysfunction is involved in the occurrence and development of cancer. The expression of MicroRNA-30b-5p (miR-30b-5p) was down-regulated in PTC; however, its role in the development of PTC is not clear. Hence, this study aimed to explore the role and mechanism of miR-30b-5p in the occurrence and development of PTC. Methods The qRT-PCR assay was used to detect the expression of miR-30b-5p in 60 cases of papillary thyroid carcinoma along with their matched non-cancerous tissues. This study explored the biological function of miR-30b-5p by the functional gain and loss experiments in vitro and vivo. The direct target gene of miR-30b-5p and its signaling pathway was identified through bioinformatics analysis, qRT-PCR, western blot, rescue experiments, and double luciferase 3'-UTR report analysis. Results This study demonstrated that the low expression of miR-30b-5p is related to poor clinicopathological features. Functionally, the overexpression of miR-30b-5p inhibited the proliferation, invasion, and migration of PTC cells. Bioinformatics and luciferase analysis showed that GALNT7 is the direct and functional target of miR-30b-5p. Moreover, miR-30b-5p inhibited the proliferation of PTC in vivo by inhibiting the expression of GALNT7. The studies on the mechanism have shown that GALNT7 promotes cell proliferation and invasion by activating EGFR/PI3K/AKT kinase pathway, which can be attenuated by the kinase inhibitors. Conclusions Overall, miR-30b-5p inhibited the progression of papillary thyroid carcinoma by targeting GALNT7 and inhibiting the EGFR/PI3K/AKT pathway.

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“…miR-21 PTEN [55][56][57][58] miR-27a RKIP [59,60] miR-92b-3p PTEN [23,61] miR-130b PTEN [62] miR-146a CHOP [54] miR-224 p-21 [62] miR-324-5p FBXO11 [63] miR-425-3p AKT1 [26] miR-1269b PTEN [64] let7 a,b,c,d,e,f,g,i LIN28 [36,48] miR-29c AKT2 [65] miR-30b-5p LRP8 [66] miR-34c-3p Notch [35] miR-100-5p mTOR [25] miR-101 ABCC1, ROCK2 [67,68] miR-145-5p ABCC1 [69] miR-146a JNK2, CEACAM6, CCNJ [70][71][72] miR-181b BCL2, TGFβR1, Notch2 [73][74][75][76] miR-193 LRRC1 [77] miR-378 sCLU [78] miR-379 EIF4G2 [79] miR-381 NFkB [80] miR-451a MCL-1 [81][82][83] miR-486-5p TWF1 [84] miR-613 GJA1 [85,86] DDP-cisplatin; DDP-S miRNA-miRNA associated with DDP sensitivity; DDP-R miRNA-miRNA associated with DDP resistance.…”

Section: Ddp R/ddp S Mirna Downstream Regulation Referencementioning

confidence: 99%

MicroRNAs as Predictors of Lung-Cancer Resistance and Sensitivity to Cisplatin

Konoshenko

Lansukhay

Красильников

et al. 2022

IJMS

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Background: Platinum-based chemotherapy, cisplatin (DDP) specifically, is the main strategy for treating lung cancer (LC). However, currently, there is a lack of predictive drug-resistance markers, and there is increased interest in the development of a reliable and sensitive panels of markers for DDP chemotherapy-effectiveness prediction. MicroRNAs represent a perspective pool of markers for chemotherapy effectiveness. Objectives: Data on miRNAs associated with LC DDP chemotherapy response are summarized and analyzed. Materials and methods: A comprehensive review of the data in the literature and an analysis of bioinformatics resources were performed. The gene targets of miRNAs, as well as their reciprocal relationships with miRNAs, were studied using several databases. Results and Discussion: The complex analysis of bioinformatics resources and the literature indicated that the expressions of 12 miRNAs have a high predictive potential for LC DDP chemotherapy responses. The obtained information was discussed from the point of view of the main mechanisms of LC chemoresistance. Conclusions: An overview of the published data and bioinformatics resources, with respect to the predictive microRNA markers of chemotherapy response, is presented in this review. The selected microRNAs and gene panel have a high potential for predicting LC DDP sensitiveness or DDP resistance as well as for the development of a DDP co-therapy.

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miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8

Cited by 23 publications

References 43 publications

Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration

Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration

miR-30b-5p inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting GALNT7 via the EGFR/PI3K/AKT pathway

MicroRNAs as Predictors of Lung-Cancer Resistance and Sensitivity to Cisplatin

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