miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing–remitting multiple sclerosis

Honardoost, Mohammad Amin; Kiani-Esfahani, Abbas; Ghaedi, Kamran; Etemadifar, Masoud; Salehi, Mansoor

doi:10.1016/j.gene.2014.04.069

Cited by 87 publications

(48 citation statements)

References 30 publications

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“…For example, treatment with natalizumab resulted in differential expression of two clusters, miR‐17‐92 and miR‐106b‐25, in patients with MS, and affected CD4 + T‐cell activation and proliferation . Several microRNAs (such as miR‐326 and miR‐26a) have been reported to be associated with the pathogenesis of MS as a regulator of B‐cell, T‐cell and monocyte development . The precise role of microRNAs in the regulation of the pathogenesis of MS is not completely clear.…”

Section: Discussionmentioning

confidence: 99%

“…[34][35][36] Several micro-RNAs (such as miR-326 and miR-26a) have been reported to be associated with the pathogenesis of MS as a regulator of B-cell, T-cell and monocyte development. 23,37 The precise role of microRNAs in the regulation of the pathogenesis of MS is not completely clear. miR-326 and miR-26a were reported to regulate Th17 cell differentiation in MS. miR-155 and let-7e were reported to regulate Th1 cell differentiation in a mouse model of MS. 24,25,32 The miR-132-Surtuin-1 axis was reported to regulate B-cell cytokine production in MS. 38 Our study demonstrates for the first time that miR-140-5p could be a Th1 regulator, and therefore is associated with the pathogenesis of MS. miR-140-5p was originally found in cartilage.…”

Section: Discussionmentioning

confidence: 99%

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Inverse correlation of expression of microRNA‐140‐5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells

et al. 2016

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Summary The role of microRNA in the regulation of encephalitogenic T‐cell development is of interest in understanding the pathogenesis of multiple sclerosis (MS). Direct binding of microRNAs to their target mRNAs usually suppresses gene expression and facilitates mRNA degradation. In this study, we observed that the expression of several microRNAs was significantly altered in patients with MS. Interestingly, the expression of miR‐140‐5p, among other microRNAs, was significantly decreased in the peripheral blood mononuclear cells of patients with MS, and this microRNA may regulate encephalitogenic T helper type 1 (Th1) cell differentiation. The expression level of miR‐140‐5p was inversely correlated with disease severity with greater reduction in relapsing disease compared with remitting disease. Transfection of synthetic miR‐140‐5p in peripheral blood mononuclear cells suppressed encephalitogenic Th1 differentiation. Signal transducer and activator of transcription 1 (STAT1) was the functional target of miR‐140‐5p – transfection of the synthetic miR‐140‐5p suppressed activation of STAT1 and the expression of its downstream target, T‐bet. Our results suggested that miR‐140‐5p is probably involved in the regulation of encephalitogenic T cells in the pathogenesis of MS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inverse correlation of expression of microRNA‐140‐5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells

et al. 2016

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“…It has been reported that M‐MDSC acquires phenotypic, morphological, and functional features from PMN‐MDSC by a mechanism that histone deacetylase 2 (HDAC2) binds to the retinoblastoma protein (Rb1) promoter region, resulting in down‐regulation of Rb1 expression in the tumor microenvironment . The generation, proliferation, migration, and immunosuppressive effects of MDSCs are regulated by various cytokines through multiple pathways, such as IL‐4, IL‐6, IL‐10, and IL‐13, which are mainly involved in the regulation of the generation and activation of MDSCs, promoting the proliferation and enhancing the immunosuppression function of MDSCs . The cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) pathway also affects the generation and proliferation of MDSCs, thereby inhibiting the function of T cells.…”

Section: Characteristic Phenotypes Of Mdscsmentioning

confidence: 99%

Myeloid‐derived suppressor cells: Roles in the tumor microenvironment and tumor radiotherapy

Yin

Wang

et al. 2018

Intl Journal of Cancer

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Cancer progression is closely related to the tumor microenvironment in which the tumor exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, signaling molecules and the extracellular matrix. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can impact the growth and evolution of cancerous cells. One of major cell components in the tumor microenvironment is myeloid-derived suppressor cells (MDSCs), which promote tumor growth and metastasis directly or indirectly by recognizing other immune cells, producing cytokines and exerting their immunosuppression functions. MDSCs have emerged as major regulators of immune responses in cancer and key targets for treating cancer. There are many limitations and side-effect in approaches of conventional cancer therapy, including radiotherapy. It has grown up to be a burgeoning field that a combination of radiotherapy and immunotherapy applied to cancer therapy. Therefore, it is fundamental to explore the immune mechanism in the process of cancer treatment. Here, we reviewed the recent progress of MDSCs in roles of the tumor microenvironment and tumor radiotherapy.

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“…miRNA profiling has also been suggested for use in identifying biomarkers of MS and revealing new methods for diagnosing patients. miR-326 and miR-26a have emerged as potential biomarkers for discriminating between relapsing and remitting MS (Honardoost et al, 2014).…”

Section: Mirna's and Myelin Diseasementioning

confidence: 99%

MicroRNA: Key regulators of oligodendrocyte development and pathobiology

Fitzpatrick

Anderson

McDermott

2015

The International Journal of Biochemistry & Cell Biology

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miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing–remitting multiple sclerosis

Cited by 87 publications

References 30 publications

Inverse correlation of expression of microRNA‐140‐5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells

Inverse correlation of expression of microRNA‐140‐5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells

Myeloid‐derived suppressor cells: Roles in the tumor microenvironment and tumor radiotherapy

MicroRNA: Key regulators of oligodendrocyte development and pathobiology

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