MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by targeting DUSP5

Ying, Jia; Liu, Jianping; Hu, Haozhong; Duan, Qingning; Chen, Jiebin; Li, Lining

doi:10.1016/j.neures.2021.03.003

Cited by 11 publications

(9 citation statements)

References 37 publications

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“…27 HIE is associated with the polymorphisms in angiotensinogen (AGT) gene, 33 tachykinin receptor 3 (TACR3) gene, 34 caspase recruitment domain family member 8 (CARD8) gene, 35,36 nitric oxide synthase 3 (NOS3) gene, 37,38 oligodendrocyte transcription factor (OLIG2) gene, 39 but not associated with the polymorphisms in hypoxia-inducible factor 1 subunit alpha (HIF1A) functional polymorphisms. 40 Some non-coding RNAs may also play an important role in the development of HIE, such as microRNA-210, 41 microRNA-30b, 42 microRNA-204, 43 microRNA-374a-5p, 44 microRNA-139-5p, 45 microRNA-363-3p, 46 and so on.…”

mentioning

confidence: 99%

Maternal and Fetal Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Study

Chen¹,

Chen²,

Jiang³

2023

IJGM

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Background: Neonatal hypoxic-ischemic encephalopathy (HIE) leads to different degree of neurological sequelae. The incidence of HIE is relatively high, and the risk factors associated with HIE are still controversial. It is necessary to identify the risk factors associated with HIE. Methods: A total of 258 neonates (110 HIE patients and 148 controls) were enrolled in this study. The characteristics of pregnant women and fetuses during pregnancy and delivery were compared between HIE patients and controls, and the risk factors of HIE were analyzed. Results:The proportions of premature infants, low-birth-weight infants and the levels of 1-minute Apgar score, 5-minute Apgar score in HIE group were significantly lower than those in control group, while the proportion of amniotic fluid contamination in the HIE group was significantly higher than those of the controls. When HIE was taken as the end point of 1-minute Apgar score, and 5-minute Apgar score, the cut-off value of 1-minute Apgar score was 3, and 5-minute Apgar score was 7 by receiver operating characteristic (ROC) curve analysis. The results of multivariate logistic regression analysis showed that low birth weight (<2.5 kg) (

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confidence: 99%

Maternal and Fetal Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Study

Chen¹,

Chen²,

Jiang³

2023

IJGM

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“…A previous study showed that DUSP5, a direct target of miR‐32‐5p, is involved in miR‐32‐5p‐mediated neuropathic pain and neuroinflammation 38 . Moreover, miR‐363‐3p attenuates neonatal hypoxic‐ischemia encephalopathy by targeting DUSP5 39 . However, whether the expression of DUSP5 is regulated by miRNAs in RA remains unknown.…”

Section: Discussionmentioning

confidence: 99%

MiR‐216a‐3p inhibits the proliferation and invasion of fibroblast‐like synoviocytes by targeting dual‐specificity phosphatase 5

Liu

Song

et al. 2023

Int J of Rheum Dis

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Rheumatoid arthritis (RA) is a progressive autoimmune disease characterized by synovial hyperplasia and local inflammatory cell infiltration, 1,2 which eventually leads to cartilage destruction, bone erosion, and joint dysfunction. 3,4 Although the pathogenesis of RA remains to be elucidated, fibroblast-like synoviocytes (FLSs) are the effector cells of RA and play a crucial role in the inflammatory process. [5][6][7] In the inflammatory process of RA, FLS acquires the ability of excessive proliferation, secretion of pro-inflammatory cytokines, migration, and invasion, which can further aggravate RA. 8,9 However, current therapeutic strategies and drugs cannot target the activated FLS. 10 Therefore, clarifying the underlying mechanisms of abnormally activated FLS will help to explore novel therapeutic targets and approaches in RA.Dual-specificity phosphatase 5 (DUSP5), a member of the DUSP subfamily, can directly dephosphorylate extracellular signal-regulated kinases 1 and 2 (hereinafter referred to as ERK) 11 and is an intrinsic negative regulator of ERK. 12 It has been implicated as a major modulator of critical signaling pathways in several diseases. Previous studies confirmed that DUSP5 is a direct target gene of p53 and has tumor-suppressive functions in several types of cancer. 13,14 Recently,

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“…The miRNA miR-363-3p is associated with various diseases and its overexpression decreases cell proliferation [ 30 , 31 , 32 ]. Recently, miR-363-3p was shown to have suppressive effects on neonatal hypoxic ischemic encephalopathy [ 33 ]. In addition, miR-363-3p suppresses tumor growth and miR-363-3p inhibition facilitates cell proliferation [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Exosomal miRNA Profile in Small-for-Gestational-Age Children: A Potential Biomarker for Catch-Up Growth

Jeong

Han

Kim

et al. 2022

Genes

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Objective: The mechanism underlying postnatal growth failure and catch-up growth in small-for-gestational-age (SGA) children is poorly understood. This study investigated the exosomal miRNA signature associated with catch-up growth in SGA children. Methods: In total, 16 SGA and 10 appropriate-for-gestational-age (AGA) children were included. Serum exosomal miRNA was analyzed using next-generation sequencing (NGS). Exosomal miRNA was profiled for five SGA children with catch-up growth (SGA-CU), six SGA children without CU growth (SGA-nCU), and five AGA children. Results: Exosomal miRNA profiles were clustered into three clear groups. The exosomal miRNA expression profiles of the SGA-nCU group differed from those of the SGA-CU and AGA groups. In all, 22 miRNAs were differentially expressed between SGA-nCU and AGA, 19 between SGA-nCU and SGA-CU, and only 6 between SGA-CU and AGA. In both SGA-nCU and SGA-CU, miR-874-3p was upregulated and miR-6126 was downregulated. Therefore, these two miRNAs could serve as biomarkers for SGA. Compared with SGA-CU and AGA, miR-30c-5p, miR-363-3p, miR-29a-3p, and miR-29c-3p were upregulated in SGA-nCU, while miR-629-5p and miR-23a-5p were downregulated. These six miRNAs could be associated with growth failure in SGA-nCU children. Conclusions: SGA children without CU have a distinct exosomal miRNA expression profile compared with AGA and SGA children with CU. Exosomal miRNAs could serve as novel biomarkers for CU.

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MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by targeting DUSP5

Cited by 11 publications

References 37 publications

Maternal and Fetal Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Study

Maternal and Fetal Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Study

MiR‐216a‐3p inhibits the proliferation and invasion of fibroblast‐like synoviocytes by targeting dual‐specificity phosphatase 5

Exosomal miRNA Profile in Small-for-Gestational-Age Children: A Potential Biomarker for Catch-Up Growth

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