miR-379-5p inhibits proliferation and invasion of the endometrial cancer cells by inhibiting expression of ROR1

Mao, Liang; Chen, Hui; Min, Jie

doi:10.18388/abp.2020_5538

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…Furthermore, we noticed, the expressions of miR-379-5p and ROR1 mRNA were found to be negatively correlated. This finding was like that of Liang et al, (2021) who discovered that miR-379-5p targeted and restricted ROR1 expression, and that the effects of miR-379-5p overexpression on endometrial cancer cell proliferation, migration, and invasion were decreased after ROR1 overexpression. These findings revealed that miR379-5p inhibited endometrial cancer cell proliferation, migration, and invasion via decreasing ROR1.…”

Section: Discussionsupporting

confidence: 79%

“…To our knowledge, this is the first study to investigate the expression patterns of miR-379-5p in endometrial cancer tissue, while Liang et al only looked at its expression in endometrial cell lines in their study (Liang et al, 2021). As a result, the focus of this research was on the expression of miR-379-5p in EC and the relationship between miR-379-5p and its potential target, ROR1.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, in an EC cell line, Liang et al found a link between ROR1 expression and miR-379-5p. ROR1 could be a new miR-379-5p target, but they did not study the levels of expression in fresh tissue specimens or connect them with clinicopathological characteristics (Liang et al, 2021). As a result, the goal of this work was to investigate the expression of miR-379-5p and ROR1 in EC tissues, as well as the relationship between the two markers.…”

Section: Introductionmentioning

confidence: 99%

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MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression

Mosaad

Abdelrahman²,

Abdullatif³

et al. 2023

Asian Pac J Cancer Prev

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Objective: To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC. Methods: Fifty female of EC were joined to this study. The gene expression of miR-379-5p (by quantitative real time-PCR) and ROR1 (by quantitative real time-PCR and immunohistochemistry) were studied in EC and normal nearby endometrial tissue. Results: The gene expression of miR-379-5p was significantly downregulated while that of ROR1 was significantly upregulated in EC tissues compared to adjacent normal endometrial tissues. Furthermore, miR-379 and ROR1 expressions significantly associated with tumor stage (P< 0.045), grade (P< 0.001), myometrial invasion (P <0.001) and LN metastasis (P< 0.034). In addition, miR-3795p and ROR1 gene expression were negatively correlated (r = -0.746, P < 0.001). Conclusions: In EC, miR-379-5p can be used as a diagnostic marker, and ROR1 could be a potential target of miR-379-5p.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression

Mosaad

Abdelrahman²,

Abdullatif³

et al. 2023

Asian Pac J Cancer Prev

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“…In previous studies, miR-379-5p was overexpressed in most tumors. And overexpression of miR-379-5p in breast cancer cell lines and endometrial cancer cell lines significantly reduced the proliferative ability of cancer cell lines [ 38 , 39 ]. In this study, the expression of miR-379-5p was also found to be lower in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

GRB10 is a novel factor associated with gastric cancer proliferation and prognosis

Ren

Wang

Ren

et al. 2023

Aging

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GRB10 and its family members GRB7 and GRB14 were important adaptor proteins. They regulated many cellular functions by interacting with various tyrosine kinase receptors and other phosphorus-containing amino acid proteins. More and more studies have shown that the abnormal expression of GRB10 is closely related to the occurrence and development of cancer. In our current research, expression data for 33 cancers from the TCGA database was downloaded for analysis. It was found that GRB10 was up-regulated in cholangiocarcinoma, colon adenocarcinoma, head and neck squamous carcinoma, renal chromophobe, clear renal carcinoma, hepatocellular carcinoma, lung adenocarcinoma, lung squamous carcinoma, gastric adenocarcinoma and thyroid carcinoma. Especially in gastric cancer, the high GRB10 expression was closely associated with poorer overall survival. Further research showed that the knockdown of GRB10 inhibited proliferation and migration ability in gastric cancer. Also, there was a potential binding site for miR-379-5p on the 3′UTR of GRB10. Overexpression of miR-379-5p in gastric cancer cells reduced GRB10-regulated gastric cancer proliferation and migration capacity. In addition, we found that tumor growth was slower in a mice xenograft model with knock down of GRB10 expression. These findings suggested that miR-379-5p suppresses gastric cancer development by downregulating GRB10 expression. Therefore, miR-379-5p and GRB10 were expected to be potential targets for the treatment of gastric cancer.

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“…LINC00665, for example, is known to accelerate breast cancer progression via the miR-379-5p/LIN28B pathway [ 30 ]. Alternately, miR-379-5p inhibits endometrial cancer cell proliferation and invasion via downregulation of RTK-like orphan receptor 1 (ROR1) levels [ 31 ]. Circ_SIPA1L1 induces osteosarcoma progression via the miR-379-5p/mitogen-activated protein kinase kinase kinase 9 (MAP3K9) pathway [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Blocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis

Zheng

Wang

et al. 2021

Bioengineered

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Cancer cell chemoresistance is the primary reason behind cancer treatment failure. Previous reports suggest that circular RNA (circRNA) hsa_circ_0074027 (HC0074027) is a crucial modulator of non-small cell lung cancer (NSCLC) disease progression. Herein, we delineated the underlying mechanism of HC0074027-regulated chemoresistance in NSCLC. We employed quantitative real-time polymerase chain reaction (qRT-PCR) or Elisa in the detection of HC0074027, micoRNA-379-5p (miR-379-5p), and insuline-like growth factor I (IGF1) expressions. Cell survival was evaluated via the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Direct associations among HC0074027, miR-379-5p, and IGF1 were examined via dual-luciferase reporter (DLR) and RNA immunoprecipitation (RIP) assays. Lastly, HC0074027 was incorporated into nude mice to examine its biological activity in vivo. Based on our analysis, HC0074027 levels strongly correlated with NSCLC chemoresistance to docetaxel (DTX), cisplatin (DDP), and paclitaxel (PTX). Alternately, HC0074027 silencing enhanced chemosensitivity in vitro. In vivo, HC0074027 downregulation suppressed tumor expansion and increased cancer cell sensitivity to chemotherapy. We also revealed that HC0074027 physically interacts with miR-379-5p to exert its biological function in vitro. Moreover, IGF1 is a functionally crucial target of miR-379-5p in modulating NSCLC chemoresistance in vitro. Finally, we

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miR-379-5p inhibits proliferation and invasion of the endometrial cancer cells by inhibiting expression of ROR1

Cited by 6 publications

References 33 publications

MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression

MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression

GRB10 is a novel factor associated with gastric cancer proliferation and prognosis

Blocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis

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