miR-429 inhibits migration and invasion of breast cancer cells in vitro

Ye, Zhibin; Ma, Gang; Zhao, Yahui; Xiao, Yun; Zhan, Yanqiang; Jing, Chao; Gao, Kai; Liu, Zhihua; Yu, Shichong

doi:10.3892/ijo.2014.2759

Cited by 75 publications

(69 citation statements)

References 39 publications

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“…In addition, overexpression of miR-429 inhibited PDAC cell growth via targeting TANK-binding kinase 1 (22). Ye et al (23) reported that miR-429 inhibited the migration and invasion of breast cancer cells via inhibition of zinc finger E-box binding homeobox 1 and Crk-like expression.…”

Section: Discussionmentioning

confidence: 99%

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

Xiao

Zhou

2016

Oncology Letters

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Section: Discussionmentioning

confidence: 99%

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

Xiao

Zhou

2016

Oncology Letters

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“…However, the detailed molecular mechanisms responsible for BC cell invasion remain unclear. Recently, miRNAs have emerged as an important mechanism responsible for BC cell invasion (29,30). In this study, we demonstrated that the expression levels of miR-214 were upregulated in BC tissues compared with adjacent benign tissues.…”

Section: Discussionmentioning

confidence: 57%

microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53

Wang

et al. 2015

International Journal of Molecular Medicine

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Abstract. Breast cancer (BC) is the foremost cause of cancerrelated mortality in women worldwide. An increasing number of studies has confirmed that microRNAs (miRNAs or miRs) play an important role in the development and progression of BC. microRNA-214 (miR-214), a member of the miRNA family, has been demonstrated to function as both a tumor suppressor and oncogene in various types of human cancer. However, the biological function of miR-214 in BC remains unclear. The present study was designed to investigate the potential role of miR-214 in the development and progression of BC. Our results revealed that miR-214 expression was significantly increased in the BC tissues compared with the adjacent benign tissues, and that the upregulation of miR-214 was significantly associated with the invasion ability of the BC cells. Furthermore, p53, which has been reported to be downregulated in BC, was predicted to be the target gene of miR-214 using bioinformatics software programs. Moreover, luciferase reporter vectors were constructed and it was confirmed that p53 is a target of miR-214. Following the transfection of miR-214 into BC cells, we found that the overexpression of miR-214 markedly enhanced cell invasion through the downregulation of p53 expression. By contrast, the overexpression of p53 abrogated the effects of miR-214. In conclusion, this study demonstrates that miR-214 functions as an oncogene in BC, at least partly by promoting cell invasion through the downregulation of p53. Therefore, miR-214 may be a potential therapeutic target for the treatment of BC.

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“…Previous studies have demonstrated that miR-429 regulates oncogenic expression in human cells, including c-myc (28), onecut 2 (18), ZEB1 (30), v-crk avian sarcoma virus CT10 oncogene homolog-like (31) and B-cell lymphoma 2 (32). Therefore, upregulation of miR-429 or providing analogous pharmaceutical compounds exogenously may be effective cancer therapy for RCC, leading to the regulation of these oncogenic transcripts.…”

Section: Sp1 Is a Direct Target Of Mir-429 To Further Confirm Thatmentioning

confidence: 99%

Tumor-suppressing effects of microRNA-429 in human renal cell carcinoma via the downregulation of Sp1

Niu

Pan

et al. 2016

Oncology Letters

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Abstract. MicroRNA (miR)-429 has been frequently reported to be downregulated in various tumors, including renal cell carcinoma (RCC), nasopharyngeal carcinoma, Ehrlich ascites tumor cells, gastric cancer, non-small cell lung cancer and endometrial endometrioid carcinoma. The present study investigated the effects of miR-429 on human RCC A498 and 786-O cells. Following transfection of cells with miR-429 mimics and scrambled control, MTT, cell migration, cell invasion and luciferase assays were performed. In addition, western blotting was performed in order to assess the expression of specificity protein 1 (Sp1), which was predicted to be a target of miR-429 by TargetScan. The present results revealed that miR-429 inhibited cell proliferation, migration and invasion of 786-O and A498 cells. In addition, the present results demonstrated that miR-429 overexpression downregulated Sp1 protein expression, which provides evidence that miR-429 may directly target Sp1 in RCC. These results suggest that miR-429 may be investigated for use as a predictive marker for early detection of tumor metastasis and blocking RCC cells from becoming invasive.

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miR-429 inhibits migration and invasion of breast cancer cells in vitro

Cited by 75 publications

References 39 publications

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53

Tumor-suppressing effects of microRNA-429 in human renal cell carcinoma via the downregulation of Sp1

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