miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma

Shu-hong, Man; Li, Xiaohan; Zhu, Wei

doi:10.3892/ol.2021.12763

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Elevated PSMG3 levels found in the plasma of glioblastoma multiforme (GBM) patients help distinguish those with sarcoidosis and healthy patients [50]. In addition, a significant number of lncRNA-PSMG3 and miRNA-PSMG3 axis regulatory mechanisms were reported to be associated with malignant diseases, including lung cancer [66][67][68][69]. On the contrary, limited literature has described the relationship between PSMG4 and human diseases, especially tumors.…”

Section: Discussionmentioning

confidence: 99%

“…More specifically in terms of malignancies, earlier studies revealed that PSMG1 was related to increasing susceptibility to inflammatory bowel disease which can lead to colon cancer-related diseases 26 , 27 , whereas a co-expression relationship of NUP37 with PSMG1 was proposed to play a specific role in breast cancer 28 . PSMG3 is characterized as an oncogenic driver factor in various types of cancer, remarkably breast cancer and cervical squamous cell carcinoma 29 . PSMG4 variants, on the other hand, were some of the differential proteomics identified in Epstein-Barr virus-associated gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic and Immune Infiltration Value of Proteasome Assembly Chaperone (PSMG) Family Genes in Lung Adenocarcinoma

Xuan¹,

Yeh²,

Su³

et al. 2023

Int. J. Med. Sci.

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The complexity of lung adenocarcinoma (LUAD) including many interacting biological processes makes it difficult to find therapeutic biomarkers for treatment. Previous studies demonstrated that PSMG (proteasome assembly chaperone) family members regulate the degradation of abnormal proteins. However, transcript expressions of this gene family in LUAD still need to be more fully investigated. Therefore, we used a holistic bioinformatics approach to explore PSMG genes involved in LUAD patients by integrating several high-throughput databases and tools including The Cancer Genome Atlas (TCGA), and Kaplan-Meier plotter database. These data demonstrated that PSMG3 and PSMG4 were expressed at significantly higher levels in neoplastic cells than in normal lung tissues. Notably, increased expressions of these proteins were correlated with poor prognoses of lung cancer patients, which probably confirmed their fundamental roles in the staging of LUAD tumors. Meanwhile, it was also indicated that there were positive correlations between PSMG family genes and the immune response, metabolism of ubiquinone, cell cycle regulatory pathways, and heat shock protein 90 (HSP90)/phosphatidylinositol 3-kinase (PI3K)/Wnt signaling. Experimental data also confirmed that the knockdown of PSMG4 in LUAD cell lines decreased cell proliferation and influenced expressions of downstream molecules. Collectively, this study revealed that PSMG family members are novel prognostic biomarkers for LUAD progression, which also provide new therapeutic targets of LUAD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic and Immune Infiltration Value of Proteasome Assembly Chaperone (PSMG) Family Genes in Lung Adenocarcinoma

Xuan¹,

Yeh²,

Su³

et al. 2023

Int. J. Med. Sci.

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“…Interestingly, overexpression of lncRNA PSMG3-AS1 can distinguish glioblastomas from sarcoidosis and reduce the inhibitory effects of miR-34a on GBM cell proliferation ( Chen et al, 2020 ). Moreover, it has been shown that overexpression of PSMG3-AS1 could increase cervical squamous cell carcinoma cell invasion and migration, which miR-441738 inhibits ( Man et al, 2021 ). Besides, MiR-449b-5p targets lncRNA PSMG3-AS1 to suppress cancer cell proliferation in lung adenocarcinoma ( Yue et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying Autophagy-Related lncRNAs and Potential ceRNA Networks in NAFLD

Cao

Guan

et al. 2022

Front. Genet.

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Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease with complex pathogenesis, which brings economic burden to the society, and there is still no effective therapy. Impaired autophagy has been implicated in the development of NAFLD. Long noncoding RNAs (lncRNAs) are also reported to play a role in the pathogenesis of NAFLD. However, the role of autophagy-related lncRNAs in NAFLD disease has not been elucidated. Here, we mined GSE135251, GSE160016, GSE130970 and GSE185062 datasets from the Gene Expression Omnibus database (GEO) and obtained the human autophagy-related gene list from the Human Autophagy Database (HADb) for in-depth bioinformatic analysis. Following differential expression analysis and intersection of the datasets, Pearson correlation analysis was performed on DElncRNAs and autophagy-related DEmRNAs to obtain autophagy-related lncRNAs, and then Starbase3.0 and TargetScan7.2 were used to construct competing endogenous RNAs (ceRNA) regulatory networks. We constructed four lncRNA-dominated ceRNA regulatory networks (PSMG3-AS1, MIRLET7BHG, RP11-136K7.2, LINC00925), and visualized with Cytoscape. Then we performed co-expression analysis of the ceRNA networks and autophagy-related genes, and functionally annotated them with Metascape. Finally, we performed receiver operating characteristic curve (ROC) analysis on lncRNAs and mRNAs within the ceRNA networks. Conclusively, our project is the first to study autophagy-related lncRNAs in NAFLD and finally mined four autophagy-related lncRNAs (PSMG3-AS1, MIRLET7BHG, RP11-136K7.2, LINC00925). We suggested that the four autophagy-related lncRNAs may be closely associated with the occurrence and development of NAFLD through the corresponding ceRNA regulatory networks. This research brings new horizons to the study of NAFLD.

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Analysis of the prognostic significance and potential mechanisms of lncRNAs associated with m6A methylation in papillary thyroid carcinoma

Huang

Chen

et al. 2021

International Immunopharmacology

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miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma

Cited by 3 publications

References 20 publications

Prognostic and Immune Infiltration Value of Proteasome Assembly Chaperone (PSMG) Family Genes in Lung Adenocarcinoma

Prognostic and Immune Infiltration Value of Proteasome Assembly Chaperone (PSMG) Family Genes in Lung Adenocarcinoma

Identifying Autophagy-Related lncRNAs and Potential ceRNA Networks in NAFLD

Analysis of the prognostic significance and potential mechanisms of lncRNAs associated with m6A methylation in papillary thyroid carcinoma

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