2016
DOI: 10.3892/or.2016.4882
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miR-493-5p attenuates the invasiveness and tumorigenicity in human breast cancer by targeting FUT4

Abstract: Abstract. Breast cancer is a leading cause of cancer-related mortality among women. Altered fucosylation was found to be closely associated with tumorigenesis and metastasis of breast cancer. MicroRNAs (miRNAs) are important regulators of cell proliferation and metastasis, and aberrant miRNA expression has been observed in breast cancer. The present study aimed to evaluate the level of fucosyltransferase IV (FUT4) and miR-493-5p in breast cancer and investigate their relationship. In the present study, we demo… Show more

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Cited by 47 publications
(35 citation statements)
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“…29 Furthermore, miR-493-5p directly targeted and inhibited FUT4 expression in breast cancer. 30 In the current study, in silico prediction has identified miR-26a and miR-26a targeting FUT4 in CRC cells, and forced expression of miR-26a and miR-26a phenocopied the effects of FUT4 depletion in CRC cell lines, supporting a role of the two miRNAs in regulating FUT4 expression in CRC. Furthermore, we observed significant inverse relationship between miR-26a and miR-26a and FUT4 expression in 38 pairs of CRC tissues, corroborating the biological relevance of this regulatory network in CRC.…”
Section: Discussionsupporting
confidence: 62%
“…29 Furthermore, miR-493-5p directly targeted and inhibited FUT4 expression in breast cancer. 30 In the current study, in silico prediction has identified miR-26a and miR-26a targeting FUT4 in CRC cells, and forced expression of miR-26a and miR-26a phenocopied the effects of FUT4 depletion in CRC cell lines, supporting a role of the two miRNAs in regulating FUT4 expression in CRC. Furthermore, we observed significant inverse relationship between miR-26a and miR-26a and FUT4 expression in 38 pairs of CRC tissues, corroborating the biological relevance of this regulatory network in CRC.…”
Section: Discussionsupporting
confidence: 62%
“…mir-493-5p has been previously implicated in the process of carcinogenesis by regulating a number of target genes, including c-MET, EGFR (Wang et al, 2017), integrin subunit beta 1 (ITGB1) (Liang et al, 2017), and fucosyltransferase IV (FUT4) (Zhao et al, 2016) in various tumor types, including breast, prostate, and lung cancers. However, no previous implication of miR-493-5p in DNA repair or responsiveness to chemotherapy has been reported.…”
Section: Discussionmentioning
confidence: 99%
“…In our dataset, low levels of miR-548j-5p and high levels of miR-93-3p were associated with short OS. Upregulation of miR-494-3p has been linked to lung cancer progression and worse survival in lung cancer patients [34], whereas miR-493-5p has been described as a suppressor of invasiveness in breast cancer [35]. In a study of microRNAs associated with resistance to radiotherapy in NSCLC patients, miR-495-3p demonstrated a higher abundance in plasma of those with complete response than in those with less response to the treatment [36].…”
Section: Discussionmentioning
confidence: 99%