2016
DOI: 10.18632/oncotarget.11252
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miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma

Abstract: Angiosarcoma is a rare malignant mesenchymal tumor with poor prognosis. We aimed to identify malignancy-associated miRNAs and their target genes, and explore biological functions of miRNA and its target in angiosarcoma. By miRNA microarrays and reverse transcription polymerase chain reaction, we identified 1 up-regulated miRNA (miR-222-3p) and 3 down-regulated miRNAs (miR-497-5p, miR-378-3p and miR-483-5p) in human angiosarcomas compared with human capillary hemangiomas. The intermediate-conductance calcium ac… Show more

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Cited by 57 publications
(52 citation statements)
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“…Recent reports have shown that KCa3.1 is highly expressed in breast cancer, intrahepatic cholangiocarcinoma, glioblastoma, and other tumors relative to normal tissues . Consistent with these reports, our results showed that KCa3.1 was upregulated in the poorly differentiated HCC group both at mRNA and protein levels, compared to the adjacent noncancerous group.…”
Section: Discussionsupporting
confidence: 92%
“…Recent reports have shown that KCa3.1 is highly expressed in breast cancer, intrahepatic cholangiocarcinoma, glioblastoma, and other tumors relative to normal tissues . Consistent with these reports, our results showed that KCa3.1 was upregulated in the poorly differentiated HCC group both at mRNA and protein levels, compared to the adjacent noncancerous group.…”
Section: Discussionsupporting
confidence: 92%
“…miR-5590-3p suppresses the gastric tumorigenesis by negatively regulating DDX5/AKT/m-TOR pathway [5]. Recently, some studies have shown that miR-497-5p functions as a tumor suppressive miRNA in various cancers, including melanoma [6], osteosarcoma [7] and angiosarcoma [8]. The hTERT, ADP ribosylation factor-like protein 2 and KCa3.1 are potential target of miR-497-5p in these cancers.…”
Section: Introductionmentioning
confidence: 99%
“…Of them, miR‐497‐5p shows a pivotal role in human cancers as a tumor suppressor miRNA. It has been reported that miR‐497‐5p overexpression negatively regulated the calcium‐activated potassium channel (KCa3.1) level and prevented angiosarcoma development (Chen et al, 2016). Study of osteosarcoma cells revealed that the inhibitory impact of miR‐497‐5p on proliferation and invasion of human MG‐63 osteosarcoma cells could be mediated by downregulation of angiomotin (Ruan, Wang, Feng, Xue, & Zhang, 2016).…”
Section: Discussionmentioning
confidence: 99%