2021
DOI: 10.1101/2021.06.13.448256
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

miR-544-3p mediates arthritis pain through regulation of FcγRI

Abstract: Chronic or episodic joint pain is a major symptom in rheumatoid arthritis (RA) and its adequate treatment represents an unmet medical need. However, the cellular and molecular mechanisms underlying RA pain remain elusive. Non-coding microRNAs (miRNAs) have been implicated in the pathogenesis of RA as negative regulators of the stability or translation of specific target mRNAs. Yet, their significance in RA pain is still not well defined. We and other groups recently identified neuronally expressed FcγRI as a k… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 52 publications
0
1
0
Order By: Relevance
“…MiR-544-3p is markedly reduced in the DRG of RA mouse models and targets neuronal FcgRI to mediate acute joint pain hypersensitivity induced by IgG immune complexes (Liu et al, 2021). Similarly, miR-146a and the miR-183 cluster are also robustly downregulated in the DRG (L4/L5) and spinal cord after experiencing knee joint OA pain in rats (Li X. et al, 2013).…”
Section: Micrornasmentioning
confidence: 99%
“…MiR-544-3p is markedly reduced in the DRG of RA mouse models and targets neuronal FcgRI to mediate acute joint pain hypersensitivity induced by IgG immune complexes (Liu et al, 2021). Similarly, miR-146a and the miR-183 cluster are also robustly downregulated in the DRG (L4/L5) and spinal cord after experiencing knee joint OA pain in rats (Li X. et al, 2013).…”
Section: Micrornasmentioning
confidence: 99%