2017
DOI: 10.1038/cddis.2017.525
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MiR-629 promotes human pancreatic cancer progression by targeting FOXO3

Abstract: The FOXO signaling pathway has been reported to have an important role in human cancer. Expression of miR-629 was markedly upregulated in pancreatic cancer and negatively correlated with FOXO3. Therefore, exploring the regulatory mechanism of miR-629 and FOXO3 signaling may provide valuable clinical targets for pancreatic cancer therapy. In the current study, we found that overexpressing and inhibiting miR-629, respectively, enhanced and reduced the cell proliferation and metastasis of pancreatic cancer cells … Show more

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Cited by 48 publications
(45 citation statements)
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“…Additionally, there was no significant correlation between the metastasis of tested cell lines and the expression level of miR-629-5p . Similar to previous studies [ 12 , 13 , 24 ], miR-629-5p functioned as an oncogene by promoting proliferation and migration and repressing apoptosis and drug sensitivity. These results suggest that miR-629-5p is a potential biomarker and therapy target for colorectal cancer.…”
Section: Discussionsupporting
confidence: 84%
See 2 more Smart Citations
“…Additionally, there was no significant correlation between the metastasis of tested cell lines and the expression level of miR-629-5p . Similar to previous studies [ 12 , 13 , 24 ], miR-629-5p functioned as an oncogene by promoting proliferation and migration and repressing apoptosis and drug sensitivity. These results suggest that miR-629-5p is a potential biomarker and therapy target for colorectal cancer.…”
Section: Discussionsupporting
confidence: 84%
“…Here, we found that miR-629-5p was up-regulated both in colorectal cancer tissues and cell lines. However, its extent of up-regulation in colorectal cancer is significantly lower than that in other cancer types [ 12 , 24 ], indicating a potential varied regulation of miR-629-5p in different types of cancer. Additionally, there was no significant correlation between the metastasis of tested cell lines and the expression level of miR-629-5p .…”
Section: Discussionmentioning
confidence: 99%
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“…The role of STAT3 in tumor development and progression is widely documented [103]. While the dysregulation of several microRNAs (miRs), such as let-7 [104] and miR-629 [105], might induce oncogenic transformation of epithelial cells through reciprocal STAT3 signaling, STAT3-driven tumor development largely results from loss of competent immune signaling and the induction of inflammatory responses in the TME [103]. Growth factors, such as vascular endothelial growth factor (VEGF) and TGF-β, in addition to a variety of cytokines, including IL-6, IL-17, IL-10, granulocyte-macrophage colony-stimulating factor (GM-CSF), and leukemia inhibitory factor (LIF), produced by both stromal and tumor cells, promote STAT3 activation.…”
Section: Tumor Growth and Immune Evasionmentioning
confidence: 99%
“…For instance, Chen et al found that nuclear accumulation of FoxO3a in tumor cells was linked with the increased radiosensitivity of esophageal carcinoma (15). Meanwhile FoxO3a, which could be regulated by miRNAs, will notably induce radiation resistance in several cancer (28)(29)(30)(31)(32). Based on the early ndings, we postulated that functional inhibition of FoxO3a expression may attenuate the radioresistance of malignant glioma.…”
Section: Discussionmentioning
confidence: 83%