miR-7641 modulates the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells

Yoo, Jung Ki; Jung, Ho Yong; Kim, Chang‐Hyun; Son, Woo Sung; Kim, Jin Kyeoung

doi:10.1007/s12272-013-0067-9

Cited by 26 publications

(23 citation statements)

References 31 publications

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“…In addition, the expression of miR-7641 was downregulated during the endothelial differentiation of human ESCs. The overexpression of this miRNA significantly suppressed the expression of CXCL1 (a member of the CXC chemokine family) [63] . CXCL1, which is involved in EC biogenesis and angiogenesis, is known to promote neovascularization by binding G-protein-coupled receptors [64,65] .…”

Section: Endothelial Cell Differentiationmentioning

confidence: 99%

MicroRNAs as novel regulators of stem cell fate

Choi

Hwang³

2013

WJSC

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Mounting evidence in stem cell biology has shown that microRNAs (miRNAs) play a crucial role in cell fate specification, including stem cell self-renewal, lineagespecific differentiation, and somatic cell reprogramming. These functions are tightly regulated by specific gene expression patterns that involve miRNAs and transcription factors. To maintain stem cell pluripotency, specific miRNAs suppress transcription factors that promote differentiation, whereas to initiate differentiation, lineagespecific miRNAs are upregulated via the inhibition of transcription factors that promote self-renewal. Small molecules can be used in a similar manner as natural miRNAs, and a number of natural and synthetic small molecules have been isolated and developed to regulate stem cell fate. Using miRNAs as novel regulators of stem cell fate will provide insight into stem cell biology and aid in understanding the molecular mechanisms and crosstalk between miRNAs and stem cells.Ultimately, advances in the regulation of stem cell fate will contribute to the development of effective medical therapies for tissue repair and regeneration. This review summarizes the current insights into stem cell fate determination by miRNAs with a focus on stem cell self-renewal, differentiation, and reprogramming. Small molecules that control stem cell fate are also highlighted.© 2013 Baishideng. All rights reserved. Key words:MicroRNA; Stem cell fate; Differentiation; Self-renewal; Reprogramming; Small molecule Core tip: Stem cells are important in regenerative medicine applications due to their capacity to self-renew and differentiate into specific cell types. MicroRNAs (miRNAs) are short non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. Recent studies suggest that miRNAs are key molecules in the regulation of stem cell fate decisions; this regulation is manifested as the fine tuning of cell-and tissue-specific gene expression. This review summarizes the current insights into stem cell fate determination by miRNAs and focuses on stem cell self-renewal, differentiation, and reprogramming. Small molecules that control stem cell fate are also highlighted.

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Section: Endothelial Cell Differentiationmentioning

confidence: 99%

MicroRNAs as novel regulators of stem cell fate

Choi

Hwang³

2013

WJSC

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“…miR-141 regulates colonic leukocytic trafficking by targeting CXCL12 during murine colitis and human Crohn's disease [62]. miR-7641 can modulate the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells [63]. miR-126 bounds directly to the 3'-UTR of CCL2 mRNA, and overexpression of miR-126 in a human monocyte/macrophage cell line can attenuate CCL2 production [64].…”

Section: Mirnas and Chemokinesmentioning

confidence: 99%

Could MicroRNAs be Regulators of Gout Pathogenesis?

Wang¹,

Xu²,

Wang³

et al. 2015

Cell Physiol Biochem

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MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthritis. In the present review, we systemically discuss relevant publications in order to provide a better understanding on the possible role of miRNAs in gout. miRNAs may act as regulators of gout pathogenesis via several pathways. Targeting miRNAs may be a promisingstrategy in the treatment of gout.

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“…Among them, miR-5739 and miR-6087 modulate the expression of endoglin [139,140], miR-6078 targets the E-cadherin (Cdh) gene [140], while miR-7641 suppresses expression of CXCL1 [141].…”

Section: Other Mirnasmentioning

confidence: 99%

An updated view on the differentiation of stem cells into endothelial cells

Zhou

Yang

Chen

et al. 2014

Sci. China Life Sci.

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Endothelial cells form the internal barrier between circulating blood and the vessel wall. They regulate arterial activity and mediate pathological reactions to vascular injuries such as atherosclerosis and balloon angioplasty. The development and differentiation of endothelial cells is a complex and coordinated process involving multiple levels of signaling and transcriptional and post-transcriptional regulation. Elucidating the mechanism of endothelial differentiation will not only enhance our understanding of vascular disease pathogenesis, but also facilitate our ability to produce vessels cells from pluripotent stem cells for regeneration purposes. In this review, we discuss the current understanding of how stem cells differentiate into endothelial cells at the level of signaling, transcription and microRNA regulation.

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miR-7641 modulates the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells

Cited by 26 publications

References 31 publications

MicroRNAs as novel regulators of stem cell fate

MicroRNAs as novel regulators of stem cell fate

Could MicroRNAs be Regulators of Gout Pathogenesis?

An updated view on the differentiation of stem cells into endothelial cells

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